Advanced Skills Development in Glyco-Hematology and Glyco-Oncology

糖血液学和糖肿瘤学高级技能发展

• 批准号: 9305126
• 负责人: Umesh Ramanlal Desai
• 金额: $ 12.26万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9305126
• 关键词: Achievement; Address; Applications Grants; Area; Attention; Biochemistry; Biological Markers; Biological Response Modifier Therapy; Biology; Blood; Blood Cells; Blood Coagulation Factor; Blood Proteins; Cardiovascular Diseases; Cell Separation; Cells; Chemistry; Clinical; Development; Diagnostic; Disease; Doctor of Philosophy; Educational Activities; Educational process of instructing; Future; Future Generations; Generic Drugs; Glycosaminoglycans; Hematology; Heparin; Human; Human Biology; Knowledge; Laboratories; Literature; Malignant Neoplasms; Medicine; Milk; Molecular Weight; National Research Council; Pharmaceutical Chemistry; Pharmacologic Substance; Pharmacology; Pharmacy Students; Plasma; Polysaccharides; Postdoctoral Fellow; Procedures; Program Development; Property; Proteins; Recombinants; Reporting; Research; Research Personnel; Research Technics; Role; Scientist; Stem cells; Structure; Techniques; Technology; Therapeutic; Trademark; Training; Training Programs; Translational Research; United States National Academy of Sciences; Universities; Work; cancer cell; cancer stem cell; career; education planning; education research; experience; graduate student; hands on research; innovation; interest; oncology; programs; protein B; research and development; skill acquisition

 DESCRIPTION (provided by applicant): The 2012 National Research Council (NRC) report titled `Transforming Glycoscience: A Roadmap for the Future' from the National Academy of Sciences, USA states that "Relatively little attention has been paid to this class of molecules, and glycoscience remains a relatively understudied field". The current RFA HL-15-006 attempts to address this state through development of creative educational activities that focus on "research area related to blood research, clinical procedures for research, or specialized research techniques. [e.g.] techniques for blood glycoscience, ... stem cell isolation/handling techniques " (see Section 1 of the RFA). In this grant application, we propose a skills development program that relies on a combination of didactic courses and hands-on research to train future generation scientists with expertise in the glycosciences of importance to hematology and oncology. Our program focuses on understanding structural and functional aspects of a) low and ultralow molecular weight heparins (LMWHs & ULMWHs) and b) N/O-glycans (NOGs) of blood proteins/cells. We proposed to 1) develop a research education plan that combines didactic teaching, literature analysis and hands-on research to train a cadre of graduate students and postdocs in the areas of glyco-hematology and glyco-oncology; 2) develop innovative research modules on structural and functional characterization of LMWHs/ULMWHs (modules 1 and 2) and NOGs of coagulation factors (module 3) and cancer stem cells (module 4); and 3) disseminate results and achievement in both skills development and research to enhance the impact of glycosciences in the biological and therapeutic arena. The combination of the teaching program proposed here with four highly innovative research modules is expected to impart the value of glycoscience to the young trainees, while also generating substantial new knowledge, technology and translational science that advances their careers. A distinguishing point about our program is its pharmaceutical/therapeutic (or translational) relevance. (End of Abstract)

 描述（由申请人提供）：美国国家科学院 2012 年国家研究委员会 (NRC) 题为《转变糖科学：未来路线图》的报告指出，“对此类分子的关注相对较少，和糖科学仍然是一个相对未被充分研究的领域”。当前的 RFA HL-15-006 试图通过开发创造性的教育活动来解决这一问题，这些活动的重点是“与血液相关的研究领域”研究、临床研究程序或专门研究技术，[例如]血液糖科学技术，……干细胞分离/处理技术”（参见 RFA 第 1 节）。在本拨款申请中，我们提出了一项技能发展计划。依靠教学课程和实践研究相结合，培养具有对血液学和肿瘤学重要的糖科学专业知识的下一代科学家。我们的计划重点是了解 a) 低分子量和超低分子量肝素的结构和功能方面。 (LMWHs 和 ULMWHs) 和 b) 血液蛋白/细胞的 N/O-聚糖 (NOGs) 我们建议 1) 制定一个结合教学、文献分析和实践研究的研究教育计划来培养研究生骨干。糖血液学和糖肿瘤学领域的学生和博士后；2) 开发 LMWH/ULMWH 结构和功能表征的创新研究模块（模块 1 和2) 凝血因子（模块 3）和癌症干细胞（模块 4）的 NOG；以及 3) 传播技能开发和研究方面的成果和成就，以增强此处提出的糖科学在生物和治疗教学领域的影响。具有四个高度创新的研究模块，预计将向年轻学员传授糖科学的价值，同时产生大量新知识、技术和转化科学，以促进他们的职业生涯。药物/治疗（或转化）相关性（摘要结束）