Femtosecond Laser Enhanced Aqueous Outflow Facility

飞秒激光增强水流出设施

• 批准号: 6784555
• 负责人: TIBOR JUHASZ
• 金额: $ 5.37万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784555
• 关键词: Macaca mulatta; computer program /software; conjunctiva; disease /disorder model; eye circulation; eye laser surgery; glaucoma; intraocular aqueous flow; laboratory rabbit; lasers; mathematical model; model design /development; morphology; nonhuman therapy evaluation; scanning electron microscopy; sclera; surgery material /equipment; technology /technique development; wound healing

DESCRIPTION (provided by applicant): Femtosecond laser pulses can be delivered through transparent and translucent tissue to perform high precision surgical procedures without damage to superficial or adjacent tissues. These unique properties of femtosecond laser-tissue interactions may provide a marked advantage over traditional laser techniques for high precision subsurface procedures. We hypothesize that the application of femtosecond lasers to the treatment of glaucoma has several potential advantages over traditional surgical and laser treatments. Among these advantages, localized tissue effects, intra-scleral capabilities, highly precise beam delivery through the conjunctiva and sclera, minimally invasive treatments, short procedure times and a potentially decreased healing response are significant. To test our hypothesis we propose the evaluation of femtosecond laser created intra-scleral fistulas of various geometries for the facilitation of aqueous outflow. Initially, a comprehensive in vitro tissue study will be performed to understand the effects femtosecond laser cut fistulas on aqueous outflow and refine geometric requirements. Theoretical modeling of the aqueous outflow dynamics will also be performed in order to deeper understand the flow dynamics and to aid channel optimization. To ensure precise drainage channel creation, ultrasound imaging will be used to monitor the surgical procedures. Ultrasound imaging is a powerful tool that can provide high-resolution visualization of the femtosecond laser treatments in both optically transparent and non-transparent tissue. After the completion of the in vitro investigations animal experiments are planned to study the effect of femtosecond laser created intra-scleral fistulas on the aqueous humor outflow in vivo. Optimization of the experimental apparatus and surgical procedures will be first accomplished, allowing the execution of long-term wound-healing studies. The longevity and effectiveness of the femtosecond laser procedures will be compared to those of traditional surgical and laser therapies tested under similar conditions. The successful completion of this project will provide a proof of concept for a minimally invasive, high precision femtosecond laser treatment of glaucoma. Additionally, by providing information on the in vivo physiological properties of the aqueous humor outflow, the results will add to our understanding of the etiology and mechanisms of glaucoma.

描述（由申请人提供）：飞秒激光脉冲可以通过透明和半透明的组织传递，以执行高精度的手术程序，而不会损害浅表或相邻组织。飞秒激光 - 组织相互作用的这些独特性能可能比传统激光技术具有明显的优势，以实现高精度地下程序。我们假设飞秒激光器在青光眼治疗中的应用比传统的手术和激光治疗具有多个潜在的优势。在这些优点中，局部组织效应，统计的能力，通过结膜和巩膜高度精确的光束递送，微创治疗，短程序时间和潜在的愈合反应均显着。为了检验我们的假设，我们提出对飞秒激光的评估，创建了各种几何形状的骨内瘘，以促进水流流出。 最初，将进行一项全面的体外组织研究，以了解femsecond激光切割瘘管对水性流出和完善几何需求的影响。还将执行水性流出动力学的理论建模，以深入了解流动动力学并帮助通道优化。为了确保创建精确的排水通道，将使用超声成像来监视外科手术程序。超声成像是一种强大的工具，可以在光秒透明和非透明组织中提供飞秒激光处理的高分辨率可视化。 在完成体外研究后，计划研究动物实验，以研究飞秒激光的影响，从而在体内产生了骨内瘘管对水性幽默流出的影响。将首先完成实验设备和手术程序的优化，从而可以执行长期伤口治疗研究。飞秒激光程序的寿命和有效性将与在类似条件下测试的传统手术和激光疗法的寿命和有效性进行比较。 该项目的成功完成将提供概念证明，用于对青光眼的微创，高精度飞秒激光治疗。此外，通过提供有关水性幽默流出的体内生理特性的信息，结果将增加我们对青光眼病因和机制的理解。