Novel Dense Hollow Fiber for Blood-Gas Exchange

用于血气交换的新型致密中空纤维

• 批准号: 6751208
• 负责人: Jean Montoya
• 金额: $ 42.88万
• 依托单位: MEDARRAY, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6751208
• 关键词: artificial membranes; biomedical equipment development; blood oxygenator; circulatory assist; extracorporeal circulation; hemodynamics; hollow fiber separation technique; respiratory gas transport; sheep; silicon compounds; technology /technique development

DESCRIPTION (provided by applicant): We have devised a technique that will greatly simplify and make cost effective the fabrication of dense silicone membrane hollow fibers (SMHF) for use in blood gas exchange applications including long-term extracorporeal life support, implantable artificial lung, and other cardiorespiratory procedures. The SMHF can be used to make non-porous, high performing, and economically attractive compact oxygenators, analogous to microporous membrane hollow fiber (MMHF) devices. Current devices using MMHF are prevalent because of enhanced gas exchange due to the convective mixing induced by blood flowing over thousands of tiny hollow fibers. This property allows for designing highly efficient gas exchange devices in relatively compact volumes. Yet MMHF suffer from fowling, and plasma leakage when they are used for extended periods of time, and from gas embolization when the gas side pressure exceeds the blood side pressure. Nonetheless there is currently no analogous non-microporous hollow fiber oxygenators. The present SMHF incorporates the compactness and effectiveness of MMHFs plus the ability to withstand plasma leakage and gas embolization. In Phase 1 we demonstrated that the SMHF can be fabricated continuously and reliably using our proprietary process, and that test oxygenating modules using our SMHF perform comparably to the MMHF counterparts. In Phase 2 we propose to further develop and scale-up the fabrication technique to evaluate the gas exchange, hemodynamic performance, and resistance to plasma breakthrough of the SMHF in adult size oxygenators. These studies will be performed on the bench as well as in-vivo.

描述（由申请人提供）： 我们设计了一种技术，可大大简化致密硅酮膜中空纤维 (SMHF) 的制造并使其具有成本效益，用于血气交换应用，包括长期体外生命支持、植入式人工肺和其他心肺手术。 SMHF 可用于制造无孔、高性能且具有经济吸引力的紧凑型充氧器，类似于微孔膜中空纤维 (MMHF) 装置。目前使用 MMHF 的设备很普遍，因为血液流经数千根微小中空纤维时会引起对流混合，从而增强了气体交换。这一特性允许在相对紧凑的体积中设计高效的气体交换装置。然而，MMHF在长时间使用时会发生鸟鸣和血浆泄漏，并且在气体侧压力超过血液侧压力时会发生气体栓塞。尽管如此，目前还没有类似的非微孔中空纤维氧合器。目前的 SMHF 结合了 MMHF 的紧凑性和有效性以及承受血浆泄漏和气体栓塞的能力。在第一阶段，我们证明了可以使用我们的专有工艺连续可靠地制造 SMHF，并且使用我们的 SMHF 测试充氧模块的性能与 MMHF 同类产品相当。在第二阶段，我们建议进一步开发和扩大制造技术，以评估成人尺寸氧合器中 SMHF 的气体交换、血流动力学性能和对血浆突破的抵抗力。这些研究将在实验室和体内进行。