Quality of Life Over Time: DCIS vs Early Breast Cancer

随着时间的推移，生活质量：DCIS 与早期乳腺癌

• 批准号: 6677641
• 负责人: DONNA B JEFFE
• 金额: $ 30.64万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-04 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6677641
• 关键词: anxiety; behavioral /social science research tag; breast neoplasms; clinical research; comorbidity; depression; female; human middle age (35-64); human old age (65+); human subject; interview; longitudinal human study; neoplasm /cancer classification /staging; postoperative state; quality of life; social support network

DESCRIPTION (provided by applicant): Diagnosis of ductal carcinoma in situ (DCIS) of the breast has increased with more widespread use of screening mammography. Although there is considerable research about quality of life (QOL) in women with invasive breast cancer, there is little pertaining to QOL in women with DCIS, and there are no longitudinal QOL studies comparing women with DCIS, women with early-stage (Stages I and II) breast cancer, and women without breast cancer. Therefore, this study will describe and compare QOL among these three groups of women. The specific aims are to 1) characterize the QOL of women with DCIS over time, 2) Identify differences in the QOL over time among DCIS and early-stage breast cancer patients and healthy controls, and 3) identify predictors of QOL among women with DCIS from among demographic, clinical, and psychosocial factors assessed at baseline. DCIS and breast cancer patients will be identified prospectively by collaborating surgeons. Women with normal or benign mammograms will be identified prospectively at I time of screening and randomly selected for the control group after being matched by age group (40-49, 50-69, and 70+) with the patients. Recruitment letters signed by the collaborating surgeons or radiologist (controls) will be mailed with consent forms and followed up with a telephone call to answer questions. Following consent, telephone interviews at 1 month, 6 months, 1 year, and 2 years after surgery (patients) or after a screening mammogram (controls) will be used to collect data. The Functional Assessment of Cancer Therapy-Breast (FACT-B) will be used to compare QOL of women with DCIS and early breast cancer and the RAND 36-Item Health Survey 1.0 wilt be used to compare the QOL between healthy controls and women with DCIS and early breast cancer. In addition, data about demographic, clinical, and psychosocial factors that may be important predictors of QOL will be collected. Differences in QOL among the three groups over time will be tested using generalized estimating equations. Multi-level models, which take into account the longitudinal approach of the study, will identify predictors of QOL among the three groups. Findings from this study may lead to ways to improve the QOL of women diagnosed with DCIS.

描述（由申请人提供）：随着筛查乳房X线摄影的广泛使用，乳房原位（DCI）的导管癌的诊断增加了。尽管关于侵入性乳腺癌女性的生活质量（QOL）有很多研究，但与DCI的女性有关QOL几乎没有关于QOL的研究，并且没有纵向QOL研究比较DCIS的女性，患有DCIS的女性，早期（I阶段I和II）乳腺癌的妇女，以及患有乳腺癌的女性。因此，这项研究将描述和比较这三组妇女中的QoL。具体目的是对1）表征DCI的QoL随时间推移，2）确定DCIS和早期乳腺癌患者和健康对照的QoL QoL的差异，以及3）确定DCI的QOL的预测因素，来自人口统计学，临床，临床和心理因素在基础线上评估。 DCIS和乳腺癌患者将被前瞻性地确定外科医生。患有正常乳房X线照片或良性乳房X线照片的妇女将在筛查时前瞻性地识别出与患者相匹配（40-49、50-69和70+）后，将其随机选择为对照组。合作外科医生或放射科医生（控制）签署的招聘信将通过同意书邮寄，并随后打电话回答问题。同意后，将使用手术后1个月，6个月，1年和2年的电话采访（患者）或筛查乳房X线照片（对照组）来收集数据。癌症治疗乳腺癌（FACT-B）的功能评估将用于比较DCIS和早期乳腺癌女性的QOL和RAND 36-项目健康调查1.0 WILT可用于比较健康对照组与DCIS和早期乳腺癌的QOL。此外，将收集有关可能是QoL重要预测指标的人口，临床和社会心理因素的数据。随着时间的推移，这三个组之间的质量差异将使用广义估计方程进行测试。考虑到研究的纵向方法，多级模型将确定这三个组之间的QOL预测指标。这项研究的结果可能导致改善被诊断为DCI的妇女的QoL。