Quality of Life Over Time: DCIS vs Early Breast Cancer

随着时间的推移，生活质量：DCIS 与早期乳腺癌

• 批准号: 6677641
• 负责人: DONNA B JEFFE
• 金额: $ 30.64万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-04 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6677641
• 关键词: anxiety; behavioral /social science research tag; breast neoplasms; clinical research; comorbidity; depression; female; human middle age (35-64); human old age (65+); human subject; interview; longitudinal human study; neoplasm /cancer classification /staging; postoperative state; quality of life; social support network

DESCRIPTION (provided by applicant): Diagnosis of ductal carcinoma in situ (DCIS) of the breast has increased with more widespread use of screening mammography. Although there is considerable research about quality of life (QOL) in women with invasive breast cancer, there is little pertaining to QOL in women with DCIS, and there are no longitudinal QOL studies comparing women with DCIS, women with early-stage (Stages I and II) breast cancer, and women without breast cancer. Therefore, this study will describe and compare QOL among these three groups of women. The specific aims are to 1) characterize the QOL of women with DCIS over time, 2) Identify differences in the QOL over time among DCIS and early-stage breast cancer patients and healthy controls, and 3) identify predictors of QOL among women with DCIS from among demographic, clinical, and psychosocial factors assessed at baseline. DCIS and breast cancer patients will be identified prospectively by collaborating surgeons. Women with normal or benign mammograms will be identified prospectively at I time of screening and randomly selected for the control group after being matched by age group (40-49, 50-69, and 70+) with the patients. Recruitment letters signed by the collaborating surgeons or radiologist (controls) will be mailed with consent forms and followed up with a telephone call to answer questions. Following consent, telephone interviews at 1 month, 6 months, 1 year, and 2 years after surgery (patients) or after a screening mammogram (controls) will be used to collect data. The Functional Assessment of Cancer Therapy-Breast (FACT-B) will be used to compare QOL of women with DCIS and early breast cancer and the RAND 36-Item Health Survey 1.0 wilt be used to compare the QOL between healthy controls and women with DCIS and early breast cancer. In addition, data about demographic, clinical, and psychosocial factors that may be important predictors of QOL will be collected. Differences in QOL among the three groups over time will be tested using generalized estimating equations. Multi-level models, which take into account the longitudinal approach of the study, will identify predictors of QOL among the three groups. Findings from this study may lead to ways to improve the QOL of women diagnosed with DCIS.

描述（由申请人提供）：随着筛查性乳房X线照相术的广泛使用，乳腺导管原位癌（DCIS）的诊断有所增加。尽管有大量关于浸润性乳腺癌女性生活质量 (QOL) 的研究，但与 DCIS 女性生活质量相关的研究很少，而且没有比较 DCIS 女性、早期（第一阶段）女性的纵向 QOL 研究。 II) 乳腺癌和未患乳腺癌的女性。因此，本研究将描述和比较这三组女性的生活质量。具体目标是 1) 描述 DCIS 女性随时间的生活质量特征，2) 确定 DCIS 和早期乳腺癌患者以及健康对照随时间的生活质量差异，以及 3) 确定 DCIS 女性生活质量的预测因素从基线评估的人口统计、临床和心理社会因素中得出。 DCIS 和乳腺癌患者将由合作外科医生前瞻性地识别。乳房 X 光检查正常或良性的女性将在筛选时前瞻性地被识别，并在与患者年龄组（40-49、50-69 和 70+）匹配后随机选择为对照组。由合作外科医生或放射科医生（对照）签署的招聘信将与同意书一起邮寄，并随后通过电话回答问题。征得同意后，将在手术后 1 个月、6 个月、1 年和 2 年（患者）或筛查性乳房 X 光检查（对照）后进行电话访谈来收集数据。乳房癌症治疗功能评估 (FACT-B) 将用于比较 DCIS 女性和早期乳腺癌女性的生活质量，兰德 36 项健康调查 1.0 将用于比较健康对照组和 DCIS 女性之间的生活质量和早期乳腺癌。此外，还将收集人口统计、临床和心理社会因素的数据，这些因素可能是生活质量的重要预测因素。将使用广义估计方程来测试三组之间的生活质量随时间的差异。考虑到研究的纵向方法的多层次模型将确定三组中生活质量的预测因素。这项研究的结果可能会带来改善诊断为 DCIS 的女性生活质量的方法。