Administrative Core

行政核心

• 批准号: 10708920
• 负责人: James R. Heath
• 金额: $ 37.85万
• 依托单位: INSTITUTE FOR SYSTEMS BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708920
• 关键词: Acceleration; Accountability; Advocate; Awareness; Biological; Cancer Biology; Clinic; Clinical; Clinical Oncology; Combination immunotherapy; Combined Modality Therapy; Communication; Communities; Cutaneous Melanoma; Data; Education and Outreach; Educational Materials; Educational process of instructing; Engineering; Environment; Evaluation; Faculty; Feedback; Funding; Goals; Immunotherapy; Infrastructure; Institution; Intellectual Property; Learning; Logistics; Malignant Neoplasms; Mentors; Monitor; Patients; Persons; Pilot Projects; Process; Program Description; Protocols documentation; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; STEM field; Schedule; Scientist; Self-Examination; Series; Solid Neoplasm; Specimen; Structure; Students; Systems Biology; Talents; Thinking; Tissues; Training Support; Translations; Underrepresented Minority; Underrepresented Populations; biobank; collaborative environment; design; flexibility; inhibitor; meetings; mouse model; multiple omics; outreach program; programs; spatiotemporal; targeted treatment; teacher; tool; translational goal; translational potential; tumor

Administration and Coordination Core Project Summary The administrative and coordination core of the proposed U54 Center for Spatiotemporal Tumor Analytics for Guiding Sequential Targeted Inhibitor : Immunotherapy Combinations (ST-Analytics is designed to promote and support the integrated research efforts of scientists from the ISB, Yale, and UCLA, as well as our Outreach program, our Pilot Projects and Cross-Consortium Projects. The scientific programs of ST-Analytics are designed to resolve how to best harness immunotherapy/targeted therapy sequential combinations for the treatment of solid tumors in the clinic, starting with a focus on metastatic cutaneous melanoma. This requires bringing together a cross-disciplinary mix of clinical, biological, physical, engineering, and computational scientists, as well as state-of-the-art, multiomic profiling tools, syngeneic mouse models, and a rich bio-repository of highly relevant patient tissues. Meeting the ST-Analytics scientific goals requires a responsive administrative structure that (i) promotes and enables effective communication and resource sharing between the ST-Analytics researchers and the broader Cancer Systems Biology Consortium (CSBC), (ii) establishes a highly interactive environment wherein ST-Analytics researchers can be good students and teachers of each other, (iii) promotes achieving the program specific aims in a timely manner, (iv) intervenes as early as possible when scientific and logistic conflicts arise, (v) promotes diversity in our scientific workforce through various mechanisms, including but not limited to seed project funding, outreach programs, and raising awareness of these critical issues during our remote and in-person meetings, and (vi) monitoring the scientific integrity and robustness of scientific designs. The ST-Analytics administrative CORE should facilitate the free flow of data, new ideas, experimental protocols, customized reagents, and biospecimens between the institutions. It should establish working relationships with other funded centers. It should facilitate clinical or commercial translation and educational outreach. It should encourage flexible thinking in anticipation of new opportunities or unexpected roadblocks. Finally, it should facilitate a healthy environment of self-evaluation.

管理与协调核心 项目摘要 拟议U54时空肿瘤分析中心的行政和协调核心 指导顺序靶向抑制剂：免疫疗法组合（ST-Analytics设计用于 促进和支持来自ISB，耶鲁大学和加州大学洛杉矶分校的科学家的综合研究工作，以及我们 外展计划，我们的试点项目和跨第一个项目。 St-Analytics的科学计划 旨在解决如何最好地利用免疫疗法/靶向治疗的顺序组合 诊所中实体瘤的治疗，首先关注转移性皮肤黑色素瘤。这需要 将临床，生物，物理，工程和计算的跨学科组合汇总在一起 科学家以及最先进的多构谱工具，合成鼠标模型和丰富的生物重复性 高度相关的患者组织。实现ST-Analytics科学目标需要响应迅速的行政 （i）促进和启用ST分析之间有效的沟通和资源共享的结构 研究人员和更广泛的癌症系统生物联盟（CSBC），（ii）建立了高度互动的 ST-Analytics研究人员可以成为好学生和老师的环境，（iii）促进 达到该计划的特定目的是及时的，（iv）在科学和 出现后勤冲突，（v）通过包括各种机制，包括 但不仅限于种子项目资金，外展计划，并提高了对这些关键问题的认识 我们的遥远和面对面的会议，以及（vi）监视科学的科学完整性和鲁棒性 设计。 St-Analytics行政核心应促进数据的自由流，新想法，实验性 机构之间的协议，定制试剂和生物测量。它应该建立工作 与其他资助中心的关系。它应该促进临床或商业翻译和教育 外展。它应该鼓励灵活的思考，以期待新的机会或意外的障碍。 最后，它应该促进自我评估的健康环境。