New Horizons in Adult Neurogenesis

成人神经发生的新视野

• 批准号: 8991062
• 负责人: AMELIA J EISCH
• 金额: $ 12.04万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2016-08-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8991062
• 关键词: Addictive Behavior; Address; Adult; Affect; Affinity Chromatography; Amelia; Animal Model; Applications Grants; Award; Bacterial Artificial Chromosomes; Behavior; Behavioral; Brain; Brain region; Candidate Disease Gene; Cells; Clinical; Cocaine; Cocaine Dependence; Cognitive deficits; Collaborations; Complex; Cues; Data; Data Collection; Detection; Development; Development Plans; Disease; Dissection; Doctor of Philosophy; Dose; Drug Addiction; Drug usage; Electrophysiology (science); Environment; Extinction (Psychology); Funding; Future; Goals; Grant; Health; Heroin; Hippocampus (Brain); Human; Immediate-Early Genes; Immunohistochemistry; Independent Scientist Award; Knowledge; Lead; Learning; Life; Light; Link; Medical center; Memory; Mentors; Molecular; Molecular Genetics; Morphine; Morphine Dependence; Morphology; Mus; National Institute of Drug Abuse; Neurons; Neurosciences; Opiate Addiction; Opiates; Pathway interactions; Pharmaceutical Preparations; Phase; Predisposing Factor; Process; Psychiatry; Publications; RNA; Recovery; Relapse; Research; Rewards; Ribosomes; Role; Running; Secure; Self-Administered; Series; Source; Stress; Structure; Symptoms; Synapses; Techniques; Testing; Time; Translating; Withdrawal; Work; addiction; adult neurogenesis; base; behavioral response; career; career development; dentate gyrus; drug of abuse; drug relapse; drug reward; improved; in vivo; indexing; injured; insight; mid-career faculty; nerve stem cell; neuroadaptation; neurogenesis; novel; novel strategies; optogenetics; relating to nervous system; repaired; response; social; stem cell biology

DESCRIPTION (provided by applicant): This is a renewal application for a NIDA Independent Scientist Award (K02). The candidate, Amelia J. Eisch, Ph.D., is a tenured Associate Professor in the Department of Psychiatry at UT Southwestern Medical Center. Dr. Eisch is a pioneer in understanding the reciprocal relationship between certain forms of hippocampal plasticity such as adult hippocampal neurogenesis and behaviors relevant to addiction. The first award period of this K02 provided Dr. Eisch with the protected time she needed to accomplish her past goals, which included renewing her NIDA R01 grant on opiates and neurogenesis, securing additional federal funding, advancing her work from correlative to more mechanistic and "causative" studies, and being promoted to Associate Professor and receiving tenure. This K02 renewal is requested in order to continue this protected time and to allow Dr. Eisch to utilize the momentum she has established in understanding the proposed reciprocal role between new neurons in the adult brain and addiction. The receipt of a K02 renewal award would allow her continued protection from administrative burdens, and thus allow Dr. Eisch to advance: (1) research on the relationship between adult-generated neurons and behaviors relevant to addiction; (2) dissection of the cellular, molecular, and genetic control of adult-generated hippocampal neurons; (3) newly developed collaborations on translational profiling, ultrastructural analysis, and circuit-level impact of new neurons; (4) application of new techniques for these collaborations (BAC-TRAP, optogenetics, EM, electrophysiology); (5) data collection for grant applications: the 10-year renewal of her existing R01 on opiates and neurogenesis, a new NIDA R01 relevant to the molecular control of hippocampal neurogenesis, and a new NIDA R01 relevant to behavioral and circuit-level impact of adult-generated neurons. By providing this protected time, Dr. Eisch can work closely with her collaborators and rapidly advance her new ideas, thus benefitting the fields of addiction research and stem cell biology and neuroscience as a whole. The stability and protected time offered by this K02 award would ultimately support at least two new projects exploring the intriguing relationship between adult-generated hippocampal neurons and behaviors relevant to addiction. As these studies hold great potential to improve our understanding of the complex mechanisms by which drugs of abuse affect brain function, they therefore may open new avenues for treatment of addiction and relapse to drug seeking. As these studies also will also shed much-needed light on how adult-generated neurons influence complex behavior - such as drug/context association, extinction from drug-seeking, and behavioral response to stress - they will be important to future efforts to harness neural stem cells for repair of the injured, even addicted, brain and to our understanding of what new neurons can/will do in the adult brain.

描述（由申请人提供）：这是 NIDA 独立科学家奖 (K02) 的续展申请。该候选人名叫 Amelia J. Eisch 博士，是 UT 西南医学中心精神病学系的终身副教授。艾施博士是理解某些形式的海马可塑性（例如成人海马神经发生）与成瘾相关行为之间相互关系的先驱。 K02 的第一个奖励期为 Eisch 博士提供了实现过去目标所需的受保护时间，其中包括更新她关于阿片类药物和神经发生的 NIDA R01 拨款、确保额外的联邦资金、将她的工作从相关性推进到更加机械化和“因果”研究，并晋升为副教授并获得终身教职。请求更新 K02 是为了继续这段受保护的时间，并允许 Eisch 博士利用她在理解成人大脑中新神经元与成瘾之间拟议的相互作用方面所建立的势头。获得 K02 续签奖将使她能够继续免受行政负担，从而使 Eisch 博士能够推进：（1）成人产生的神经元与成瘾相关行为之间关系的研究； (2) 解剖成年海马神经元的细胞、分子和遗传控制； (3) 在新神经元的翻译分析、超微结构分析和电路水平影响方面新开展的合作； (4) 新技术在这些合作中的应用（BAC-TRAP、光遗传学、EM、电生理学）； (5) 资助申请的数据收集：她现有的关于阿片类药物和神经发生的 R01 的 10 年更新，与海马神经发生的分子控制相关的新 NIDA R01，以及与行为和回路水平影响相关的新 NIDA R01成人产生的神经元。通过提供这段受保护的时间，艾施博士可以与她的合作者密切合作，并迅速推进她的新想法，从而使成瘾研究、干细胞生物学和神经科学领域整体受益。 K02 奖项提供的稳定性和保护时间最终将支持至少两个新项目，探索成人生成的海马神经元与成瘾相关行为之间的有趣关系。由于这些研究具有巨大的潜力，可以提高我们对滥用药物影响大脑功能的复杂机制的理解，因此它们可能为治疗成瘾和吸毒复发开辟新途径。由于这些研究还将揭示成人产生的神经元如何影响复杂的行为——例如药物/环境关联、寻求药物的灭绝以及对压力的行为反应——它们对于未来利用神经元的努力非常重要。干细胞用于修复受伤的、甚至成瘾的大脑，并帮助我们了解新的神经元可以/将在成人大脑中做什么。