HEAL Clinical Coordinating Resource Center for the Pain Management Effectiveness Research Network

HEAL 疼痛管理有效性研究网络临床协调资源中心

• 批准号: 10709644
• 负责人: DANIEL K. BENJAMIN
• 金额: $ 247.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709644
• 关键词: Acute pain management; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Collection; Data; Data Analyses; Dedications; Dose; Funding; Future; Helping to End Addiction Long-term; Infrastructure; Institutional Review Boards; Leadership; Longitudinal Studies; Monitor; National Center for Advancing Translational Sciences; Opioid; Pain; Pain Clinics; Pain management; Phase; Principal Investigator; Protocols documentation; Public Health; Publications; Regimen; Research Institute; Research Personnel; Resources; Risk Reduction; Safety; Sickle Cell Anemia; Speed; Translational Research; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Utah; Work; Writing; addiction; chronic pain; comparative effectiveness trial; design; effectiveness research; innovation; opioid epidemic; prevention effectiveness trial; recruit; response; success; trial design

The Helping to End Addiction Long-term (HEAL) initiative was developed to identify scientific solutions to the national opioid public health crisis as quickly as possible. As part of this initiative, the NIH HEAL Pain Management Effectiveness Research Network (HEAL Pain ERN) will continue to use the infrastructure of the NCATS Trial Innovation Network to provide scientific guidance and coordination of the HEAL Pain ERN Trials. Specifically, the three Trial Innovation Centers (TICs) at Duke/Vanderbilt, University of Utah, and Johns Hopkins/Tufts will continue to provide integrated functions for the clinical resource coordinating center (CRCC), data coordination resource center (DCRC), and the statistical and safety resource center (SSRC) for the HEAL Pain ERN. Two additional HEAL Pain ERN trials will be selected which will require full support from the HEAL Pain ERN CCRC, DCRC, and SSRRC. In addition, five ongoing trials supported by the HEAL ERN will continue to receive dedicated support from the resource centers. The Duke/Vanderbilt Trial Innovation Center is poised to: Specific Aim 1. Provide clinical trial leadership and expertise, assistance in study and protocol design, study implementation, and management, in collaboration with the other HEAL ERN Resource Centers, for existing and new HEAL ERN trials. Specific Aim 2. Serve as the clinical coordinating resource center (CCRC) for existing and new HEAL ERN trials. Specific Aim 3. Provide single IRB support for HEAL ERN trials for existing and new HEAL ERN trials. Through completion of these specific aims, we will harmonize the HEAL studies to achieve major innovations in trial design and execution, including: combination and reuse of valuable data, efficiencies of implementation, shared pain expertise among investigative teams, and the integration of three TICs as a cohesive unit, poised for future trial implementation.

开发了长期（治愈）倡议的帮助结束成瘾的倡议，以确定科学解决方案 国家阿片类药物公共卫生危机尽快。作为该计划的一部分，NIH治愈痛苦 管理有效性研究网络（Heal Pain ERN）将继续使用 NCAT试验创新网络，提供科学指导和协调性疼痛试验。 具体而言，杜克/范德比尔特，犹他大学和约翰的三个审判创新中心（TICS） 霍普金斯/簇将继续为临床资源协调中心（CRCC）提供综合功能， 数据协调资源中心（DCRC）以及治疗的统计与安全资源中心（SSRC） 疼痛。将选择两个额外的治愈疼痛ERN试验，这将需要治愈的全部支持 疼痛ERN CCRC，DCRC和SSRRC。此外，Heal Ern支持的五项正在进行的试验将 继续获得资源中心的专用支持。 公爵/范德比尔特审判创新中心有望： 具体目标1。提供临床试验领导和专业知识，研究和协议设计的帮助，研究 实施和管理与其他Heal Ern资源中心合作，以实施现有 和新的治疗ern试验。 具体目标2。作为现有和新的Heal ERN的临床协调资源中心（CCRC） 试验。 特定目标3。为现有和新的Heal ERN试验提供单一的IRB支持。 通过完成这些特定目标，我们将协调治疗研究以实现重大创新 在试验设计和执行中，包括：合并和重用有价值的数据，实施效率， 调查团队之间共享痛苦的专业知识，以及将三个抽动作为一个凝聚力单位的整合， 用于未来的审判实施。