Mentored Patient Oriented Research in Kidney Disease

指导以患者为导向的肾脏疾病研究

• 批准号: 9353804
• 负责人: Joachim H Ix
• 金额: $ 17.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-16 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9353804
• 关键词: Acute; Address; Alpha Cell; Appointment; Area; Award; Back; Biological Markers; Cardiovascular Diseases; Career Mobility; Cause of Death; Chronic Kidney Failure; Clinic; Clinical; Clinical Drug Development; Clinical Markers; Clinical Trials; Clinical Trials Design; Contracts; Data; Disease; Doctor of Philosophy; Drug Evaluation; Evaluation Research; Faculty; Fortune; Functional disorder; Funding; Generations; Goals; Grant; Individual; Intervention; Kidney Diseases; Kidney Transplantation; Knowledge; Leadership; Length; Link; Manuscripts; Measurement; Measures; Medical; Medical Students; Mentors; Mentorship; Methods; Monitor; Nephrology; Observational Study; Organ; Paper; Patient risk; Patients; Pilot Projects; Population; Postdoctoral Fellow; Process; Productivity; Publications; Publishing; Quality of life; Randomized Clinical Trials; Recruitment Activity; Renal tubule structure; Research; Research Design; Research Methodology; Research Personnel; Research Training; Schools; Science; Scientist; Secondary to; Students; Talents; Technology; Testing; Time; Toxic effect; Training; Translating; Transplant Recipients; United States National Institutes of Health; career; cell free DNA; drug development; experience; externship; high risk; improved; insight; interest; mid-career faculty; novel; novel strategies; patient oriented; patient oriented research; pre-clinical; pre-doctoral; professor; programs; research study; satisfaction; skills; success; technology/technique

ABSTRACT Since first becoming an Assistant Professor in Nephrology in 2006, I have been deeply committed to patient oriented research (POR) in nephrology, and to mentorship. This has led to considerable successes. I am PI on multiple NIH R01 awards and contracts, and am leading clinical trials in nephrology. In regards to mentorship, I am currently primary mentor to two K awardees, secondary mentor to an additional K awardee, and am also mentoring a cadre of nephrology MD and PhD post-doctoral fellows, medical residents, and pre- doctoral students. One prior mentee is leading her own R01 as PI, and several have transitioned to the Associate Professor level. My mentees have been successful garnering grant support and publishing high impact manuscripts as first author. However, with increasing demands on my time, and with the need to fund my professional effort, I am limited in my abilities to expand my mentorship activities. I have a wealth of talented potential trainees, and find great satisfaction mentoring. Similarly, by necessity, my funded research awards are built on my current skills and expertise. Yet, I am excited about new ideas that I believe can be transformative, but am ill equipped to obtain research awards and advance these ideas without additional training in the new areas of interest. My strong desire to spend more time mentoring, to expand my pool of mentees, and to obtain new research training has led me to propose this K24. Within it, my aims are to (1) to dedicate time to expand my mentorship capacities to promising junior investigators in patient oriented research in kidney disease, and (2) to obtain new research expertise in (a) cell free DNA technology, (b) approaches to FDA biomarker qualification, and (c) leadership and team management skills.

抽象的 自 2006 年首次成为肾脏病学助理教授以来，我一直致力于 肾脏病学中以患者为导向的研究（POR）以及指导。这已经取得了巨大的成功。我 我是多项 NIH R01 奖项和合同的 PI，并领导肾脏病学临床试验。关于 指导，我目前是两名 K 获奖者的主要导师，另外一名 K 获奖者的二级导师， 我还指导了一批肾脏病学博士、博士后研究员、住院医师和预科医师。 博士生。一位先前的受训者正在作为 PI 领导她自己的 R01，并且有几位已经过渡到 副教授级别。我的学员已成功获得资助并发表了高水平论文 作为第一作者影响手稿。然而，随着我的时间需求越来越多，并且需要资金 由于我的专业努力，我扩展指导活动的能力有限。我有丰富的 有才华的潜在学员，并找到非常满意的指导。同样，出于必要，我资助的研究 奖项是基于我目前的技能和专业知识。然而，我对我相信可以实现的新想法感到兴奋 变革性的，但我没有能力获得研究奖项并在没有额外的情况下推进这些想法 新的兴趣领域的培训。我强烈希望花更多时间进行指导，扩大我的人才库 受训者，并获得新的研究培训使我提出了这个 K24。其中，我的目标是（1） 花时间扩大我对以患者为导向的研究中有前途的初级研究人员的指导能力 肾脏疾病方面的研究，以及 (2) 获得以下方面的新研究专业知识：(a) 无细胞 DNA 技术，(b) 方法 FDA 生物标志物资格，以及 (c) 领导和团队管理技能。