Functional Dissection of the K27M Histone Mutation in Vivo

体内 K27M 组蛋白突变的功能解析

• 批准号: 9337512
• 负责人: Oren Josh Becher
• 金额: $ 14.1万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-10 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9337512
• 关键词: Alpha Cell; Astrocytes; Biology; Brain Neoplasms; Brain Stem; Brain Stem Glioma; Brain Stem Neoplasms; Cause of Death; Cell Proliferation; Cells; Child; Childhood Brain Neoplasm; Clinical Trials; Complex; Development; Diffuse intrinsic pontine glioma; Disease; Dissection; Dorsal; Foundations; Gene Targeting; Genes; Genetic; Genetically Engineered Mouse; Glial Fibrillary Acidic Protein; Gliomagenesis; Goals; Histone H3; Histones; Human; In Vitro; Independent Scientist Award; Laboratories; Location; Malignant Neoplasms; Malignant neoplasm of brain; Modeling; Molecular Profiling; Mus; Mutation; Neonatal; Pathogenesis; Pharmaceutical Preparations; Platelet-Derived Growth Factor; Polycomb; Proto-Oncogene Proteins c-sis; Reporting; Research; Scientist; TP53 gene; Therapeutic Agents; Treatment Efficacy; comparative; design; differential expression; effective therapy; gain of function mutation; in vivo; mouse model; mutant; nerve stem cell; nestin protein; novel; overexpression; progenitor; public health relevance; relating to nervous system; transcriptome sequencing; tumor; tumorigenesis

DESCRIPTION (provided by applicant): Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable brain tumor that arises in children. My laboratory is one of very few laboratories around the world that is studying DIPG biology using genetically engineered mouse modeling. This Independent Scientist Award will give me the opportunity to focus on research to dissect the mechanisms by which K27M histone mutations contribute to DIPG pathogenesis. Ultimately, this information will lay the groundwork for the identification of effective therapeutic agents to treat this incurable cancer.

描述（由申请人提供）：弥漫性内源性脑桥胶质瘤（DIPG）是一种发生于儿童的无法治愈的脑肿瘤。我的实验室是世界上极少数使用基因工程小鼠模型研究 DIPG 生物学的实验室之一。这项独立科学家奖将使我有机会专注于研究，剖析 K27M 组蛋白突变导致 DIPG 发病机制的机制。最终，这些信息将为识别有效治疗药物来治疗这种无法治愈的癌症奠定基础。

项目成果

A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells.

在表达 Pax3 的细胞中启动的弥漫性内源性脑桥胶质瘤的新型小鼠模型。

• 发表时间: 2016-01
• 作者: Misuraca, Katherine L;Hu, Guo;Barton, Kelly L;Chung, Alexander;Becher, Oren J
• 通讯作者: Becher, Oren J