Developing Instrumentation for Fetal Cardiac Monitoring

开发胎儿心脏监测仪器

• 批准号: 6583369
• 负责人: DOUGLAS N PAULSON
• 金额: $ 10万
• 依托单位: TRISTAN TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-21 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6583369
• 关键词: biomagnetism measurement; biomedical equipment development; cardiography; clinical research; diagnosis design /evaluation; embryo /fetus monitoring; heart function; heart rate; heart rhythm; heat; human pregnant subject; human subject; magnetic field; magnetism; noninvasive diagnosis; superconductivity

DESCRIPTION (provided by applicant): There is a strong need to assess the physiological development of the fetus, as more pre- and fullterm babies survive with possible disorders. This Phase I research will evaluate the feasibility of developing a new, non-invasive fetal magnetocardiography (fMCG) sensor, based on high temperature superconductors (HTS). The potential of fMCG is especially high for evaluating fetal rhythm disorders. Studies have shown that fMCG can detect fetal rhythm disturbances that cannot be detected by ultrasound, which is the only technology in wide use. fMCG is also a nearly ideal signal source for fetal heart rate monitoring, providing a precise signal, which can be detected throughout the last half of pregnancy. Studies have shown that fMCG can provide important diagnostic information, unobtainable by other means, which have the potential to improve the accuracy of fetal monitoring. This Phase I will (1) build a proof-of-principle HTS axial gradiometer fMCG system, with a gantry and sensor configuration based on prior MCG data from fetal heart signals, (2) assess the sensitivity of the fMCG system in terms of signal size, magnetic field resolution, and noise characteristics in shielded and unshielded envrionments, and begin to refine noise reduction software, and (3) collect fetal data at several intervals from gestation, from within the magnetically shielded room at the University of Wisconsin's Biomagnetism Research Laboratory. A major obstacle to acceptance of present-day fMCG is its high cost and sophistication. If successful, the proposed project will lead to the development of a practical instrument which can significantly improve clinical assessment of fetal cardiac function and fetal well-being.

描述（由申请人提供）：随着越来越多的前婴儿和成熟的婴儿在可能的疾病中生存，需要评估胎儿的生理发展。这项I阶段研究将根据高温超导体（HTS）来评估开发新的非侵入性胎儿心动图（FMCG）传感器的可行性。 FMCG的潜力对于评估胎儿节律疾病的潜力尤其很高。研究表明，FMCG可以检测到超声无法检测到的胎儿节律障碍，这是唯一广泛使用的技术。 FMCG也是胎儿心率监测的几乎理想的信号来源，提供了精确的信号，可以在整个怀孕的最后一半中检测到。研究表明，FMCG可以提供重要的诊断信息，而其他方式无法实现，这可能会提高胎儿监测的准确性。 该阶段I将（1）建立原则证明HTS轴向渐变级FMCG系统，并根据胎儿心脏信号的先前MCG数据进行龙门和传感器配置，（2）评估FMCG系统的敏感性，根据信号大小，磁场分辨率和噪声的噪声和噪声范围，并从屏蔽中和重新固定的噪声中，并重新构建噪声，并重新汇总，以重新汇总，并重新固定，并重新构建噪声，并重新固定，并重新汇编（重新汇总）。妊娠，来自威斯康星大学生物磁学研究实验室的磁性屏蔽室内。 接受当今快速消费的主要障碍是其高成本和成熟。如果成功的话，拟议的项目将导致开发一种实用工具，该工具可以显着改善胎儿心脏功能和胎儿健康的临床评估。