Anti-Inflamatory Coatings for Biomaterials

生物材料抗炎涂层

• 批准号: 6644217
• 负责人: JOHN A FRANGOS
• 金额: $ 86.56万
• 依托单位: LA JOLLA BIOENGINEERING INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644217
• 关键词: antioxidants; biomaterial development /preparation; biotechnology; ceramics; inflammation; surface coating

DESCRIPTION (provided by the applicant): The prolonged inflammatory response to an implant is one of the primary causes for the failure to integrate into tissue. The two sources of inflammation common to almost all implants are the foreign body response and the relative movement of the implant with the surrounding tissue. Based on evidence in the literature and from our research team, the inflammatory response is mediated by the reactive oxygen species generated by macrophages, leukocytes, and the surrounding connective tissue. Based on our findings, it is evident that titanium dioxide and similar ceramics, even when present as surface coatings of polymeric biomaterials, have the ability to breakdown reactive oxygen species that have been identified as mediators of the inflammatory response. The goal of this Program is to develop applications for our catalytic antioxidant ceramic technology in the biomaterials and medical device industry. This Program, led by UCSD, consists of five projects with ten academic and industrial partners. Project 1 will investigate the basic mechanisms of action of metal oxides in the catalytic breakdown of reactive oxygen species. By understanding the fundamental reaction kinetics of the catalytic action of titanium dioxide, catalysts of greater efficiency may be discovered. Project 2 will fabricate and characterize materials for the other four projects. This project involves partners from Lawrence Livermore National Labs, Drexel Univ., and UCSD. Project 3 will test the in vivo inflammatory and foreign body response in two in vivo models; a standard rat model and the hamster window model. This project provides a core service to the other projects, but also investigates fundamental mechanisms of the inflammatory response to biomaterials. Project 4 will determine if the catalytic antioxidant ceramic technology is able to mitigate implant-tissue strain-induced inflammation. It will also investigate basic mechanisms of strain-induced inflammation. Project 5 is the interface with the medical device industry. Four Industrial Partners have been chosen to develop to apply the technology to four different biomaterial needs: Biosensor membranes for inplantable glucose sensors (GlySens) and biodegradable polymers for tissue engineering (Advanced Tissue Sciences) with reduced foreign body response; wound dressing material with anti-inflammatory properties (3M); and. dental materials with improved soft tissue integration (Nobel BioCare). By the first year, we will have elucidated the catalytic mechanisms of action of TiO,, established the ceramic coating technologies, characterized the inflammation response in the hamster model, and fabricated and tested dental coatings. Our overall objective is to provide the proof-of-principle to our industrial partners, which will encourage them to participate in more specific product development in the second phase (years 6-10) of the BRP.

描述（申请人提供）：长期炎症反应 植入物是未能集成到的主要原因之一 组织。几乎所有植入物的炎症的两个来源是 异物反应和植入物与 周围的组织。根据文献中的证据和我们的研究 团队，炎症反应是由活性氧介导的 由巨噬细胞，白细胞和周围结缔组织产生。 根据我们的发现，很明显二氧化钛和类似 陶瓷，即使作为聚合物生物材料的表面涂层存在，也具有 被鉴定为已鉴定为的活性氧的能力 炎症反应的介体。该计划的目标是发展 在我们的催化抗氧化陶瓷技术中的应用 生物材料和医疗设备行业。由UCSD领导的该程序包括 有十个学术和工业伙伴的五个项目。项目1将 研究金属氧化物在催化中的基本机制 活性氧的分解。通过了解基本反应 二氧化钛催化作用的动力学，催化剂较大的催化剂 可能会发现效率。项目2将制造和特征 其他四个项目的材料。该项目涉及来自的合作伙伴 Lawrence Livermore国家实验室，Drexel大学和UCSD。 项目3将测试两次体内炎症和异物反应 体内模型；标准大鼠模型和仓鼠窗口模型。这个项目 为其他项目提供核心服务，但也调查 炎症反应对生物材料的基本机制。项目4 将确定催化抗氧化剂陶瓷技术是否能够 减轻植入物菌株诱导的炎症。它也会调查 应变引起的炎症的基本机制。项目5是接口 与医疗设备行业一起。选择了四个工业伙伴 开发将技术应用于四种不同的生物材料需求：生物传感器 可植入葡萄糖传感器（Glysens）和可生物降解聚合物的膜 用于降低异物的组织工程（高级组织科学） 回复;具有抗炎特性的伤口敷料材料（3M）；和。 具有改善软组织整合的牙科材料（诺贝尔生物保健）。由 第一年，我们将阐明TIO作用的催化机理 建立了陶瓷涂料技术，表征了炎症 仓鼠模型的反应，以及制造和测试的牙齿涂层。我们的 总体目标是为我们的工业提供原理证明 合作伙伴，这将鼓励他们参加更具体的产品 BRP的第二阶段（6-10年）的发展。