Iron fMRI: Improving Sensitivty and localization

铁功能磁共振成像：提高灵敏度和定位

• 批准号: 6708759
• 负责人: JOSEPH B MANDEVILLE
• 金额: $ 37.63万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-05 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6708759
• 关键词: Macaca mulatta; bioimaging /biomedical imaging; brain mapping; contrast media; functional magnetic resonance imaging; iron oxide; laboratory rat

DESCRIPTION (provided by applicant): This grant proposal, "IRON fMRI in animal models: improving sensitivity and spatial localization", is an R01 application in response to RFA EB-03-002, "Systems & Methods for Small Animal Imaging". While functional brain mapping by BOLD fMRI is a common neuroscience technique in humans, animal models enable more effective techniques that are not yet available in humans. In particular, iron oxide contrast agents (IRON fMRI) offer remarkable improvements in fMRI sensitivity, appear to provide better spatial localization than the BOLD method, but suffer a somewhat slower temporal resolution than the BOLD method. The goal of the proposed project is to resolve the principal remaining issues concerning the application of IRON fMRI in animal models. Namely, 1) what are the relative merits and IRON and BOLD fMRI at very high magnetic fields, 2) what implications does the IRON temporal response have for rapidly modulated brain activity, and 3) does blood volume produce significantly better spatial localization than BOLD signal? Our hypotheses are 1) the IRON method will fill a critical role in high field fMRI by improving image quality without a loss of sensitivity, 2) intelligent stimulation strategies will mitigate disadvantages of the slow IRON temporal response even for rapidly stimulus modulations, and 3) the IRON method will improve spatial fMRI localization. Detection sensitivity and spatial resolution are among the most critical experimental factors for effective fMRI in small animal models. The proposed experiments address the most important remaining issues concerning IRON fMRI in animal models, and these studies are a logical step in the eventual progression of this powerful technique from pre-clinical studies to clinical utility.

描述（由申请人提供）：这项拨款提案“动物模型中的 IRON fMRI：提高灵敏度和空间定位”是响应 RFA EB-03-002“小动物成像系统和方法”的 R01 申请。虽然 BOLD fMRI 的功能性大脑图谱是人类常见的神经科学技术，但动物模型可以实现人类尚不具备的更有效的技术。特别是，氧化铁造影剂 (IRON fMRI) 显着提高了 fMRI 灵敏度，似乎提供了比 BOLD 方法更好的空间定位，但时间分辨率比 BOLD 方法稍慢。拟议项目的目标是解决有关 IRON fMRI 在动物模型中应用的主要剩余问题。即，1) 在极高磁场下，IRON 和 BOLD fMRI 的相对优点是什么；2) IRON 时间响应对快速调节的大脑活动有何影响；3) 血量是否比 BOLD 信号产生明显更好的空间定位？我们的假设是 1) IRON 方法将在不损失灵敏度的情况下提高图像质量，从而在高场 fMRI 中发挥关键作用，2) 智能刺激策略将减轻慢 IRON 时间响应的缺点，即使对于快速刺激调制也是如此，3) IRON 方法将改善空间功能磁共振成像定位。 检测灵敏度和空间分辨率是小动物模型中有效功能磁共振成像的最关键实验因素之一。拟议的实验解决了动物模型中有关 IRON fMRI 的最重要的剩余问题，这些研究是这一强大技术从临床前研究到临床应用的最终进展的逻辑步骤。