Novel Amino Acid-Based Glass-Ionomer Biomaterials

新型氨基酸基玻璃离聚物生物材料

• 批准号: 6737905
• 负责人: DONG XIE
• 金额: $ 27.73万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-19 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737905
• 关键词: aminoacid; bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biotechnology; chemical synthesis; dental materials; glass; interdisciplinary collaboration; laboratory rat; orthopedics; polymers

DESCRIPTION (provided by applicant): It is known that resin-modified glass-ionomer cement (RMGIC) is an attractive dental restorative because it has enhanced mechanical strength, bonding and handling properties. However, a disadvantage of this cement is that it contains a large quantity of 2-hydroxyethyl methacrylate (HEMA). Since unreacted HEMA is cytotoxic to pulp and surrounding tissues, elimination of HEMA could make this "intelligent" cement more attractive for both dental and orthopedic applications. We have demonstrated that new and novel amino acid-modified and non-HEMA containing RMGICs exhibit significantly improved mechanical strengths, adhesion and self-etching capabilities. The objective of this research is to develop these novel amino acid based glass-ionomers for both dental and orthopedic applications, in response to NIBIB's RFA for development of novel biomaterials with improved biological and mechanical properties. In this research, inexpensive and biostable amino acid-based polycarboxylic acid will be synthesized and formulated with amino acid derivatives to form an innovative non-HEMA containing RMGIC system. Design of Experiment (DOE) methodology will be applied to optimize molar ratio, molecular weight, grafting ratio of synthesized poly(amino acid), formulations and filler contents. Mechanical strengths and other physical properties of the new cements will be evaluated. The proposed amino acid-based cements will provide extra salt-bridges, thus enhancing adhesion and mechanical strengths. In vitro direct cell contact as well as methylthiazolyldiphenyl tetrazolium (MTT) studies and in vivo bone response will be conducted to determine the biocompatibility and bioactivity of the new cements. Novel restoratives for both dentistry and orthopedics should be an outcome of this basic research to establish commercial biomaterials for future industrial development. Successful achievement of the goal of this project will significantly impact the field of restorative dentistry and orthopedic surgery. This project will create a university-wide collaboration between synthetic polymer chemist, biomaterials scientist, biomechanical engineer and clinical dentist. This project will also provide an ideal training environment for biomedical engineering students because it will allow them, through close interactions with the collaborators from different disciplines, to develop a broad perspective on biomaterials research.

描述（由申请人提供）：众所周知，树脂修饰的玻璃离子水泥（RMGIC）是一种有吸引力的牙科修复，因为它具有增强的机械强度，粘结和处理性能。然而，该水泥的缺点是它含有大量的2-羟基乙基甲基丙烯酸酯（HEMA）。由于未反应的HEMA对纸浆和周围组织是细胞毒性的，因此消除HEMA可能会使这种“智能”水泥对牙齿和骨科应用都更具吸引力。我们已经证明，新的和新颖的氨基酸修饰和非hema含量的RMGIC具有显着改善的机械强度，粘附和自我蚀刻能力。这项研究的目的是开发这些新型氨基酸的玻璃离子体为牙科和骨科应用开发，以响应尼比布的RFA，以开发具有改善生物学和机械性能的新型生物材料。在这项研究中，将合成廉价且可生物氨基酸的聚羧酸，并用氨基酸衍生物配制，形成含有创新的非Hema含有RMGIC系统。实验（DOE）方法的设计将应用于优化合成聚（氨基酸），配方和填充物含量的摩尔比，分子量，移植比。将评估新水泥的机械​​强度和其他物理特性。提出的基于氨基酸的水泥将提供额外的盐桥，从而增强粘附力和机械强度。将进行体外直接细胞接触以及将进行甲基噻唑烷基二苯基四唑（MTT）研究和体内骨反应，以确定新水泥的生物相容性和生物活性。牙科和骨科的新型恢复应成为这项基础研究的结果，以建立商业生物材料以供未来的工业发展。成功实现该项目的目标将显着影响恢复性牙科和骨科手术领域。该项目将在合成聚合物化学家，生物材料科学家，生物力学工程师和临床牙医之间建立大学范围内的合作。该项目还将为生物医学工程专业的学生提供理想的培训环境，因为这将使他们通过与来自不同学科的合作者进行密切互动，从而对生物材料研究进行广泛的观点。