5th Bone Fluid Flow Workshop

第五届骨液流动研讨会

• 批准号: 6712563
• 负责人: MELISSA L KNOTHE TATE
• 金额: $ 1万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-07 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6712563
• 关键词: bone; fluid flow; osteopenia; tissue engineering; travel; workshop

DESCRIPTION (provided by applicant): Interstitial or extravascular fluid is the coupling medium between bone matrix and bone cells. Not only is this fluid the perfusate that defines the biochemical environment of the cell, but it has been postulated to play a key role in mechanotransduction, i.e. transmission of mechanical loads incurred during physiological activity from the organ to the tissue to the cellular level. Bone cells are the "micro machines" that remodel the tissue in order to adapt to the prevailing mechanical and biochemical environment. The cues or signals that trigger this cell activity are still poorly understood. Fluid flow is a putative mechanism for remodeling activity associated with bone adaptation in health and disease. This proposal describes the logistical and conceptual plans for a 5th Bone Fluid Flow Workshop to be held in Cleveland. The past decade has been a time of revival for the field of bone fluid flow. The first workshop to review the state of the art and to discuss new developments in the field was held in New York in 1997. The current proposal for the 5th Bone Fluid Flow Workshop seeks funding to support the field at an important crossroads, where the field is on the cusp of translation to the clinic. Although great strides have been made in the past ten years, open questions and gaps in understanding still remain. This has provided the impetus to organize the workshop according to a new paradigm in 2003. The ultimate goals of the 5th Bone Fluid Flow Workshop are threefold. First, similar to previous workshops, recent breakthroughs related to fluid flow through bone will be presented. The second and third goals are unique to this workshop. Second, past assumptions regarding fluid flow through bone will be questioned and explored by addressing parallel phenomena in other biophysical systems and discussion of their implications for bone physiology. Third, critical open questions will be identified; the answers to these questions are expected to push the field into the future, providing a basis for translational research. Our specific aims are to address implications of fluid flow for bone physiology from the organ (Session 1) to the cellular (Session 2) and the subcellular (Session 3) level. Furthermore, implications of fluid flow for tissue engineering (Session 5) and patient care (Session 6) will be addressed. Finally, looking towards the future, we will close the meeting by addressing the potential role of fluid flow in microgravity-induced osteopenia, which is a condition similar to disuse osteopenia and osteoporosis on Earth (Session 7).

描述（由申请人提供）： 间质或血管外液体是骨基质和骨细胞之间的耦合介质。这种液体不仅是定义细胞生化环境的灌注液，而且被认为在机械转导中发挥关键作用，即将生理活动期间产生的机械负荷从器官到组织再传递到细胞水平。骨细胞是重塑组织以适应普遍的机械和生化环境的“微型机器”。触发这种细胞活动的线索或信号仍然知之甚少。流体流动是与健康和疾病中骨适应相关的重塑活动的假定机制。该提案描述了将在克利夫兰举行的第五届骨液流动研讨会的后勤和概念计划。过去的十年是骨液流动领域的复兴时期。第一届研讨会于 1997 年在纽约举行，旨在回顾该领域的最新技术并讨论该领域的新发展。第五届骨液流研讨会的当前提案寻求资金支持该领域的重要十字路口，其中该领域正处于转化为临床的风口浪尖。尽管过去十年取得了巨大进步，但悬而未决的问题和理解上的差距仍然存在。这为 2003 年根据新范式组织研讨会提供了动力。第五届骨液流研讨会的最终目标有三个。首先，与之前的研讨会类似，将介绍与骨中流体流动相关的最新突破。第二个和第三个目标是本次研讨会所特有的。其次，通过解决其他生物物理系统中的并行现象并讨论它们对骨生理学的影响，将质疑和探索过去关于流体流过骨的假设。第三，将确定关键的开放性问题；这些问题的答案预计将推动该领域走向未来，为转化研究提供基础。我们的具体目标是解决流体流动对从器官（第 1 节）到细胞（第 2 节）和亚细胞（第 3 节）水平的骨生理学的影响。此外，还将讨论流体流动对组织工程（第 5 节）和患者护理（第 6 节）的影响。最后，展望未来，我们将通过讨论流体流动在微重力引起的骨质减少中的潜在作用来结束会议，这种情况类似于地球上的废用性骨质减少和骨质疏松症（第 7 场）。