Exacerbation of Atherosclerosis

动脉粥样硬化恶化

• 批准号: 6609808
• 负责人: GUANGMING ZHONG
• 金额: $ 25.29万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6609808
• 关键词: Chlamydiaceae; antibiotics; antioxidants; atherosclerosis; atherosclerotic plaque; blood lipoprotein metabolism; chemoprevention; chlamydial disease; cholesterol; cytokine; dietary lipid; disease /disorder etiology; gene targeting; genetically modified animals; inflammation; laboratory mouse; low density lipoprotein receptor; nonhuman therapy evaluation; nutrition related tag; pathogenic diet; pathologic process; species difference

DESCRIPTION (provided by the applicant): Atherosclerosis is the principal contributor to the pathogenesis of myocardial and cerebral infarction, and no effective treatment is yet available for atherosclerosis. Identifying the etiological causes and understanding the pathogenic mechanisms of atherosclerosis may provide information for developing efficient strategies for preventing and/or controlling cardiovascular disease pathogenesis. Both epidemiological investigations and animal model studies have linked C. pneumoniae infection to atherosclerosis. The objectives of the present proposal are to further evaluate the role of C. pneumoniae infection in atherosclerosis in a mouse model system and to use this animal system to understand the mechanisms of C. pneumoniae atherogenesis by testing an infection / inflammatory response hypothesis. Specifically, the roles of both inflammatory responses and lipoprotein oxidation in C. pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis.

描述（由申请人提供）：动脉粥样硬化是主要的 与心肌梗塞和脑梗塞的发病机制有关，目前尚无 动脉粥样硬化尚有有效的治疗方法。识别 病因和了解发病机制 动脉粥样硬化可能为制定有效的策略提供信息 预防和/或控制心血管疾病的发病机制。两个都 流行病学调查和动物模型研究已将 C. 肺炎链球菌感染导致动脉粥样硬化。本提案的目标 进一步评估肺炎衣原体感染在动脉粥样硬化中的作用 在小鼠模型系统中并使用该动物系统来了解 通过检测感染了解肺炎衣原体动脉粥样硬化机制 / 炎症反应假说。具体来说，这两种炎症的作用 肺炎衣原体恶化的反应和脂蛋白氧化 将评估动脉粥样硬化。这些研究可能提供必要的 有关设计有效预防和控制方法的信息 C. 肺炎加剧了动脉粥样硬化。