iTarget: Institute for Biomolecular Targeting

iTarget：生物分子靶向研究所

基本信息

批准号：
9553073
负责人：
DEAN R MADDEN
金额：
$ 13.65万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-15 至 2021-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9553073
关键词：
Address Advisory Committees American Area Arts Award Awareness Basic Science Binding Biological Biology Biomedical Research Cells Centers of Research Excellence Chronic Disease Chronic Obstructive Airway Disease Clinical Clinical Sciences Colon Carcinoma Committee Members Communicable Diseases Communities Complement Core Facility Curiosities Data Development Disease Engineering Ensure Evaluation Extramural Activities Faculty Fostering Funding Glioblastoma Goals Heart Diseases Human Imagery Immunology Inflammation Institutes Institution Interdisciplinary Study Investigation Investments Knowledge Lead Leadership Lung Malignant Neoplasms Medical Mentors Modeling Molecular Molecular Epidemiology Molecular Target Neurosciences Outcome Pathology Pharmaceutical Preparations Physicians Pilot Projects Pneumonia Positioning Attribute Probability Process Productivity Proteins Proteome Publishing Pulmonary Emphysema Reagent Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Research Support Resource Sharing Resources Respiratory Syncytial Virus Infections Respiratory syncytial virus Role Schools Science Scientist Signal Transduction Structure System Technology Therapeutic Time Training Translational Research United States National Institutes of Health Universities Validation Vision Work base clinical application clinical practice design experience fundamental research health care delivery innovation insight interest knowledge translation medical schools member multidisciplinary novel therapeutic intervention novel therapeutics population based pre-clinical programs public health relevance research clinical testing screening senior faculty skills success symposium synergism tenure track therapeutic development tool

项目摘要

DESCRIPTION (provided by applicant): Investments in biomedical research have paid large dividends in the form of groundbreaking treatments for a host of diseases. Efforts to accelerate such benefits often assume there is a linear progression that begins with an understanding of basic biological principles, and then advances to therapeutic development, evaluation, and ultimately clinical application. As a result, many initiatives focus on the stages that follow discovery. Here, we propose to establish a Dartmouth Institute for Biomolecular Targeting (iTarget) that will infuse even early-stage mechanistic investigation with a sophisticated awareness of translational possibilities. This approach will ensure that knowledge of disease pathology provides focus and context to enhance the impact of even the most fundamental research. At the same time, it will target mechanistic investigations in directions that increase the probability of ultimate translational success. iTarget is structured (1) to accelerate the research productivity and scientific impact of four exceptional junior faculty members with interrelated interests in biomolecular target identification, validation, and inhibition; (2) to prvide a supportive framework for mentoring by experienced and committed senior faculty; (3) to develop essential shared research resources not available at Dartmouth or our regional IDeA partners and to facilitate access to existing cores; and (4) to recruit new faculty to the Institut. With faculty engagement from 10 departments across the Faculty of Arts and Sciences, Geisel School of Medicine, and Thayer School of Engineering, our initiative is truly multidisciplinary. Dartmouth's collegial and highly interactive faculty have outstanding strength in curiosity-based discovery, healthcare delivery and population-based outcomes analysis, and the university has made key investments in translational research. iTarget will thus benefit from natural research synergies that complement, but do not overlap with our programmatic partners. In return, iTarget will fill a critical role, bringing researchers together at the interface between basic and translational sciences. It will thus stimulate interdisciplinary and innovative research projects t address unmet therapeutic needs. It will also enhance the regional research infrastructure, providing cutting-edge strategies for generating proteins and other molecular targeting tools and for visualizing molecular interactions in purified systems and in cells. Dartmouth has also made a substantial institutional commitment to iTarget success and long-term sustainability, including the hiring of five new tenure-track faculty across campus. It will also provide program enrichment funds to support research infrastructure, scientific exchange, and a pilot project program to foster a vibrant intellectual community, recruit new members, and enhance the impact and funding competitiveness of all iTarget members. With experienced leadership, efficient administrative structures, and a compelling vision for a new paradigm that interweaves mechanistic and early- stage translational research, iTarget will develop a critical mass of extramurally funded investigators and thus thrive as a free-standing, nationally recognized Center of Biomedical Research Excellence at Dartmouth.

描述（由申请人提供）：对生物医学研究的投资以对许多疾病的突破性治疗的形式带来了巨大的红利，加速这种益处的努力通常假设存在一个线性进展，从了解基本的生物学原理开始，并且然后推进到治疗开发、评估和最终的临床应用。因此，许多举措都集中在发现之后的阶段。在这里，我们建议建立达特茅斯生物分子靶向研究所（iTarget）。这种方法将确保疾病病理学知识提供焦点和背景，以增强最基本的研究的影响，同时，它将针对早期的机制研究。 iTarget 的结构旨在 (1) 提高四名在生物分子靶点识别、验证和抑制方面具有相关兴趣的杰出初级教员的研究生产力和科学影响力；(2) 提供支持；框架由经验丰富且忠诚的高级教师提供指导；(3) 开发达特茅斯或我们的地区 IDeA 合作伙伴无法提供的重要共享研究资源，并促进获得现有核心；(4) 在教师参与的情况下招募新教师。我们的倡议来自艺术与科学学院、盖泽尔医学院和塞耶工程学院的 10 个系，是真正的跨学科项目，达特茅斯的学院和高度互动的教师在基于好奇心的发现、医疗保健服务和服务方面拥有出色的实力。基于人群的结果分析，并且大学在转化研究方面进行了重大投资，因此，iTarget 将受益于与我们的计划合作伙伴互补但不重叠的自然研究协同作用，而 iTarget 将发挥关键作用，将研究人员聚集在一起。在基本和之间的接口因此，它将刺激跨学科和创新的研究项目，以解决未满足的治疗需求，还将增强区域研究基础设施，为生成蛋白质和其他分子靶向工具以及可视化纯化系统中的分子相互作用提供尖端策略。达特茅斯学院还对 iTarget 的成功和长期可持续性做出了重大的机构承诺，包括在校园内聘用五名新的终身教职人员。它还将提供项目丰富资金，以支持研究基础设施、科学交流和试点。项目计划，以培养充满活力的知识社区，招募新成员，并增强所有 iTarget 成员的影响力和资金竞争力。凭借经验丰富的领导层、管理结构和对将机械性研究与早期高效转化研究相结合的新范式的令人信服的愿景，iTarget 将开发一个达特茅斯拥有大量外部资助的研究人员，因此成为独立的、全国公认的生物医学卓越研究中心。