Neurorehabilitation and Restorative Neuroscience Network

神经康复和恢复神经科学网络

基本信息

批准号：
9405068
负责人：
BARBARA S BREGMAN
金额：
$ 77.22万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9405068
关键词：
Basic Science Benchmarking Chronic Clinical Clinical Research Clinical Trials Complex Development Plans Discipline Disease Doctor of Philosophy Faculty Funding General Hospitals Geography Grant Health Occupations Health system Hospitals Individual Institutes Interdisciplinary Study Leadership Manuscripts Maryland Massachusetts Mentored Clinical Scientist Development Program Mentors Mentorship Mission Nervous System Trauma Nervous system structure Neurorehabilitation Neurosciences Outcome Patients Phase Population Positioning Attribute Productivity Recovery Recovery of Function Recruitment Activity Rehabilitation therapy Research Research Personnel Research Training SECTM1 gene Science Site Technology TimeLine Training Translating Travel United States National Institutes of Health Universities Vocational Guidance Writing base career development coping disability educational atmosphere effective intervention health care delivery nervous system disorder new technology programs translational neuroscience

项目摘要

The paucity of NIH-funded Phase III rehabilitation clinical trials is prima facie evidence that, despite multiple cycles of taxpayer funding, the incumbent K12 programs have fallen short in their mission of translating science into treatments for patients. We emphasize the K12 RFA’s first Background sentence: “Despite the increasing population of individuals coping with chronic disabilities at various levels, the field of medical rehabilitation has not responded sufficiently to the need for research to validate approaches, optimize treatments, and incorporate new technologies and opportunities.” Existing programs are inwardly focused and mired in supporting historical academic and clinical silos. They do not prioritize the research needs of patients or the training needed to develop investigators equipped to overcome complex disabling disorders. We intend a different approach. First, we will include all clinical disciplines, and simply recruit the best scholars. Second, we will focus on a single group of disorders: disabling chronic neurological disorders. Thus, we target a multilevel scientific approach (from molecules to outcomes), all directed at the problem of nervous system recovery and not a clinical credential. Third, we will blend the best of old and new by pairing excellent and traditional university-based training settings with more contemporary excellent healthcare delivery training settings based in nonprofit health systems. Fourth, we have assembled a leadership team composed of successful translational neuroscience/neurorehabilitation investigators with a track record of interdisciplinary research training. These individuals are national leaders, and each has a wide network for recruiting scholars and mentors nationally. Finally, we increase efficiency by reducing travel barriers with a geographically compact network and maximize trainee productivity by including an executive coaching program. Alexander Dromerick, MD and Barbara Bregman, PT, PhD are Program Directors. The coordinating site is Georgetown University and affiliated National Rehabilitation Hospital. Other primary sites: John Hopkins /Kennedy Krieger Institute (Bastian), Harvard (Schlaug), Massachusetts General Hospital Institute of Health Professions (Connor), Massachusetts Institute of Technology (Krebs), University of Maryland/Kernan (Wittenberg), and Cornell/Burke Rehabilitation Hospital (Ratan). We will provide the strongest possible interdisciplinary mentorship and training for the early career development of these K12 scholars from all neurorehabilitation disciplines in an educational environment that promotes strong interactions between basic and clinical research to develop effective interventions to promote functional recovery after neurological injuries. We will support 4 faculty scholars yearly,(2-3 years each); they will remain engaged in the K12 program activities for 5 years as they transition to independent faculty positions. Together with their local primary mentor, each scholar develops an individual career development plan that includes research training, coursework, manuscript and grant writing support with specific timelines and benchmarks for progress.

NIH 资助的 III 期康复临床试验的初步证据表明，尽管由于纳税人资助的多个周期，现有的 K12 项目未能实现其使命：我们强调 K12 RFA 的第一句话背景： “尽管在各个层面应对慢性残疾的人数不断增加，但医疗康复尚未充分满足研究的需要，以验证方法、优化方法治疗，并结合新技术和机会。” 他们陷入了支持历史学术和临床孤岛的困境，没有优先考虑患者的研究需求。或者培养能够克服复杂的致残性疾病的研究人员所需的培训。首先，我们打算采用不同的方法，包括所有临床学科，并招募最优秀的人才。其次，我们将重点关注一组疾病：致残的慢性神经系统疾病。我们的目标是采用多层次的科学方法（从分子到结果），全部针对紧张问题第三，我们将通过优秀的配对来融合新旧的精华。和传统的大学培训环境以及更现代的优秀医疗保健提供培训第四，我们组建了一个由以下人员组成的领导团队。具有跨学科记录的成功转化神经科学/神经康复研究人员这些人都是国家领导人，每个人都拥有广泛的招募学者的网络。最后，我们通过减少地理上的旅行障碍来提高效率。通过包含高管辅导计划，紧凑的网络并最大限度地提高学员的生产力。 Alexander Dromerick（医学博士）和 Barbara Bregman（PT、PhD）是项目总监。站点是乔治城大学及其附属国家康复医院其他主要站点：约翰霍普金斯大学。 /肯尼迪克里格研究所（巴斯蒂安）、哈佛大学（施劳格）、马萨诸塞州总医院健康研究所专业（Connor）、麻省理工学院（Krebs）、马里兰大学/克南分校（维滕贝格）和康奈尔/伯克康复医院（拉坦）我们将提供尽可能强大的服务。为这些来自世界各地的 K12 学者提供早期职业发展的跨学科指导和培训教育环境中的神经康复学科促进基础学科之间的强有力的互动和临床研究，以开发有效的干预措施，促进神经功能恢复我们每年将支持 4 名教员学者（每人 2-3 年）；当他们过渡到独立教职职位时，与他们当地的人一起进行为期 5 年的计划活动。首席导师，每位学者都会制定个人职业发展计划，其中包括研究培训，课程作业、手稿和拨款写作支持，以及具体的时间表和进度基准。