Data Resource for Analyzing Blood & Marrow Transplants

用于分析血液的数据资源

• 批准号: 6571794
• 负责人: Mary Maresca Horowitz
• 金额: $ 282.82万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6571794
• 关键词: autologous transplantation; automated data processing; blood transfusion; bone marrow transplantation; clinical research; computer program /software; computer system design /evaluation; cooperative study; data collection; data collection methodology /evaluation; experimental designs; health care facility information system; hematopoietic stem cells; human data; long term survivor; longitudinal human study; method development; outcomes research; patient /disease registry; quality of life; statistical service /center; statistics /biometry

DESCRIPTION (provided by applicant): The Statistical Center of the International Bone Marrow Transplant Registry (IBMTR) and the Autologous Blood and Marrow Transplant Registry of North America (ABMTR) coordinates an international effort to collect and analyze data on outcome of blood and bone marrow (hematopoietic stem cell) transplants. The IBMTR, established in 1972, and the ABMTR, established in 1990, involve >450 transplant centers in 47 countries. Participating centers submit data on consecutive transplants to the IBMTR/ABMTR Statistical Center. The Registries have data for >150,000 transplants. Statistical Center personnel have a strong record of expert and innovative analyses of HSCT issues using IBMTR/ABMTR and other data. This resource has been used extensively for determining transplant results in specific clinical situations, identifying prognostic factors, comparing transplant regimens, comparing transplant with non-transplant therapy, assessing intercenter variability in diagnosis, practice and outcome, planning clinical trials or treatment protocols, and developing approaches to evaluating transplant outcome. The proposed grant will support further development of this unique resource of data and statistical expertise. The proposal outlines several enhancements to the Statistical Center's data collection, entry and management system, including development of electronic data reporting systems and expansion of the database to include information on organizational characteristics of transplant centers and quality of life of long-term transplant survivors. It proposes educational and other efforts to improve the ability of centers to obtain follow-up on long-term survivors and a program to increase the use of this resource for planning and evaluating clinical trials. The project will also develop statistical methodologies appropriate for unbiased and efficient analyses of transplant data and provide expert statistical support for studies using IBMTR/ABMTR data.

描述（由申请人提供）： 国际骨髓移植登记处 (IBMTR) 统计中心和北美自体血液和骨髓移植登记处 (ABMTR) 协调国际努力，收集和分析血液和骨髓（造血干细胞）移植结果的数据。 IBMTR 成立于 1972 年，ABMTR 成立于 1990 年，涉及 47 个国家的超过 450 个移植中心。参与中心向 IBMTR/ABMTR 统计中心提交连续移植数据。登记处拥有超过 150,000 例移植手术的数据。统计中心人员拥有使用 IBMTR/ABMTR 和其他数据对 HSCT 问题进行专家和创新分析的丰富记录。该资源已广泛用于确定特定临床情况下的移植结果、确定预后因素、比较移植方案、比较移植与非移植治疗、评估诊断、实践和结果的中心间变异性、规划临床试验或治疗方案以及制定评估移植结果的方法。拟议的赠款将支持进一步开发这一独特的数据和统计专业知识资源。该提案概述了统计中心数据收集、输入和管理系统的几项增强功能，包括开发电子数据报告系统和扩展数据库，以纳入有关移植中心组织特征和长期移植幸存者生活质量的信息。它提出了教育和其他努力，以提高中心对长期幸存者进行随访的能力，并提出一项计划，以更多地利用这一资源来规划和评估临床试验。该项目还将开发适合移植数据公正和高效分析的统计方法，并为使用 IBMTR/ABMTR 数据的研究提供专家统计支持。