TEXAS CANCER GENETICS CONSORTIUM

德克萨斯州癌症遗传学联盟

• 批准号: 6804311
• 负责人: LOUISE C STRONG
• 金额: $ 121.78万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6804311
• 关键词: TEXAS; CANCER; GENETICS; CONSORTIUM

We propose a Texas Cancer Genetics Consortium (TCGC) in response to the Cancer Genetics Network (CGN) RFA CA-97-004. This TCGC would bring to the CGN extensive expertise in basic and clinical cancer genetics, human and molecular genetics, management of confidential human cancer genetics data, community outreach in human genetics, professional and public education, and psychosocial studies of the impact of cancer genetic counseling and testing. The TCGC will include existing cancer high risk clinical populations, Ashkenazi Jewish populations, registries of familial breast, colon, MEN2, NF1 and other genetic susceptibility syndromes, many followed in studies for decades, patients at high cancer risk participating in screening and early detection studies or chemoprevention trials, and a large database of cancer patients from which to identify high risk family members for potential recruitment to the CGN. The Texas population is diverse in ethnic makeup, and the TCGC includes investigators with proven track records in assessing needs of the Hispanic and African American communities in health care, in providing health education to those communities and their healthcare providers, and in recruiting their participation in familial cancer registries and clinical and research studies. Funding of this application would provide the opportunity for our TCGC to strengthen our within consortium interactions, to contribute our research experience and expertise to the CGN design and implementation, and to utilize our experience and expertise in recruitment of high risk patients to CGN protocols. The long term goal is to contribute to the identification of cancer susceptibility genes, their mechanisms of action, frequency, penetrance, and genetic or environmental risk modifiers, to integrate this information into optimal patient management, and to assess needs and provide education to address the ethical and psychosocial concerns surrounding human cancer genetics.

我们建议对癌症遗传学网络（CGN）RFA CA-97-004提出德克萨斯癌症联盟（TCGC）。 该TCGC将带来CGN的基本和临床癌症遗传学，人和分子遗传学，机密人类癌症遗传学数据的管理，人类遗传学，专业和公共教育的社区外展，以及对癌症遗传咨询和测试影响的心理社会研究。 TCGC将包括现有的癌症高风险临床人群，Ashkenazi犹太人人群，家族性乳房，结肠，MEN2，NF1和其他遗传易感性综合征，数十年的研究中，许多癌症的患者在高癌症风险中参与筛查和早期检测研究或招募较大的癌症患者的早期检测研究和较高的癌症患者，以及较高的癌症患者。 得克萨斯州的人口在族裔化妆方面有多样化，TCGC包括在评估西班牙裔和非裔美国人社区在医疗保健方面的需求，为这些社区及其医疗保健提供者提供健康教育的研究人员，并招募他们参与家族癌症注册表以及临床和研究研究。 该应用程序的资金将为我们的TCGC提供加强我们在联盟互动中的机会，为CGN设计和实施贡献我们的研究经验和专业知识，并利用我们的经验和专业知识来招募高风险患者参加CGN方案。 长期目标是为鉴定癌症易感性基因，其作用，频率，渗透率以及遗传或环境风险修饰剂的机制做出贡献，以将这些信息整合到最佳患者管理中，并评估需求并提供教育，以解决围绕人类癌症遗传学的伦理和心理社会问题。