The Clinical Research/Reproductive Scientist Training Program (CREST)

临床研究/生殖科学家培训计划 (CREST)

• 批准号: 8827631
• 负责人: Nanette F. Santoro
• 金额: $ 17.25万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8827631
• 关键词: Address; Adult; American; Andrology; Area; Career Choice; Child; Child health care; Clinical; Clinical Research; Clinical Trials Database; Data Analyses; Data Set; Data Sources; Databases; Discipline of obstetrics; Disease; Endocrinology; Epidemiology; Fertility; Future; Goals; Gynecology; Health; Human Development; Infertility; Institutes; Life; Menopause; Methods; Multi-Institutional Clinical Trial; NIH Program Announcements; Outcome; Ovulation Induction; Oxygen; Perception; Persons; Phase; Physicians; Physiological; Polycystic Ovary Syndrome; Population; Population Sciences; Pregnancy; Pregnancy Outcome; Process; Registries; Relative (related person); Reproduction; Reproductive Endocrinology; Reproductive Medicine; Research; Research Personnel; Research Project Grants; Research Training; Resources; Sampling; Schedule; Science; Scientist; Series; Societies; Testing; Training; Training Programs; United States National Institutes of Health; Universities; Vision; Woman; biobank; contraceptive practice; design; innovation; meetings; novel; physiologic stressor; programs; public health relevance; reproductive; reproductive epidemiology; response; skill acquisition; skills

DESCRIPTION (provided by applicant): In response to concerns about the decline in physician scientists, the relative lack of well- designed and well-executed clinical and epidemiological research in reproductive medicine, and a perception that current trainees in the Reproductive Endocrinology and Infertility subspecialty of Obstetrics and Gynecology were opting out of research career paths, the Clinical Research/Reproductive Scientist Training Program (CREST) Program was established as a partnership among key components that comprised and facilitated the training program: the Deputy Director of the National Institute for Child Health and Human Development, the Program in Reproductive and Adult Endocrinology, the American Society for Reproductive Medicine, and the Clinical Research Training Program at Duke University. Didactic training modules are designed to be online to accommodate clinicians. Weekend seminars are scheduled in conjunction with the annual American Society for Reproductive Medicine meeting (once a year) and on the NIH campus (6 months apart from the ASRM meeting). Graduates receive a certificate in Clinical Research. A group thesis project involving analysis of a large data set and a testing of skill acquisition became an optional, informal activity in the second year of CREST, undertaken after completion of the online certificate program. The CREST Program's impact and outcomes are promising and indicate that it is achieving its goal. The present proposal seeks to formalize the second year of the program to specifically incorporate a team science thesis project and promote the application of CREST Scholars' newly acquired skills to query existing population and clinical trial databases and perform secondary data analyses (Specific Aim 1) and to expand the available data sets for the second year of CREST training to include multiple data sources in Reproductive Endocrinology and Infertility, and Andrology (Specific Aim #2). These resources will provide a descriptive dataset for outcomes analysis in fertility and contraceptive practice, and generate new hypotheses for future research. The goals of the current proposal are particularly relevant to the NIH visioning process for reproduction and pregnancy research, which has both recognized the importance of viewing pregnancy as a physiologic stressor, and examining the preconceptual phase of life as a predictor of pregnancy health and disease.

描述（由申请人提供）：针对对医师科学家数量下降、生殖医学领域相对缺乏设计良好和执行良好的临床和流行病学研究的担忧，以及对生殖内分泌和不孕不育亚专科当前学员的看法由于妇产科选择退出研究职业道路，临床研究/生殖科学家培训计划 (CREST) 计划是作为关键组成部分之间的合作伙伴关系而建立的，这些组成部分和促进了培训项目：国家儿童健康和人类发展研究所、生殖和成人内分泌学项目、美国生殖医学会和杜克大学临床研究培训项目的副主任。教学培训模块旨在为临床医生提供在线教学。周末研讨会与美国生殖医学协会年会（每年一次）一起安排，并在 NIH 校园举行（与 ASRM 会议相隔 6 个月）。毕业生获得临床研究证书。涉及大型数据集分析和技能获取测试的小组论文项目成为 CREST 第二年的一项可选的非正式活动，在完成在线证书课程后进行。 CREST 计划的影响和成果是有希望的，表明它正在实现其目标。目前的提案旨在正式确定该计划的第二年，专门纳入一个团队科学论文项目，并促进 CREST 学者新获得的技能的应用，以查询现有人群和临床试验数据库并进行二次数据分析（具体目标 1）和扩大 CREST 培训第二年的可用数据集，以包括生殖内分泌学和不孕症以及男科学的多个数据源（具体目标#2）。这些资源将为生育和避孕实践的结果分析提供描述性数据集，并为未来的研究提出新的假设。当前提案的目标与 NIH 生殖和妊娠研究的愿景过程特别相关，该过程都认识到将妊娠视为生理应激源的重要性，并检查生命的孕前阶段作为妊娠健康和疾病的预测因素。