Dissolvable Hydrogel Dressing for the Treatment of Burns

用于治疗烧伤的可溶性水凝胶敷料

基本信息

批准号：
9010534
负责人：
MARK W. GRINSTAFF
金额：
$ 39.18万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-02-01 至 2019-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9010534
关键词：
Adhesives Animal Model Animals Biocompatible Materials Body Surface Burn Trauma Burn injury Burning Pain Caring Characteristics Chemistry Clinic Clinical Clinical Trials Collection Complex Contracts Cysteine Data Data Analyses Debridement Development Devices Economics Elasticity Environment Evaluation Excision Exposure to Exudate Family Family suidae Fire - disasters Fluid Balance General Anesthesia Generations Goals Healed Hour Humidity Hydrogels Impaired wound healing In Vitro Infection Injury Knowledge Link Liquid substance Mechanics Modeling Movement Nerve Operating Rooms Operative Surgical Procedures Opioid Pain Pathology Patients Pediatric Hospitals Performance Physiological Process Property Rattus Reporting Rheology Running Safety Secondary to Secure Series Services Site Skin Specialist Sterile coverings Structure-Activity Relationship Sulfhydryl Compounds Surface Surgeon Survivors Testing Time Tissues Toxic effect Translations Trauma Wound Healing aqueous base biomaterial compatibility design disability evaporation experience healing implantation in vivo in vivo Model injured novel pain receptor prototype psychologic public health relevance research study social subcutaneous thioester wound

项目摘要

DESCRIPTION: This application describes the synthesis, characterization, and evaluation of a hydrogel dressing that dissolves and can be easily removed from the wound surface of a patient with second degree burns with no further trauma. Burns are one of the most common and devastating forms of trauma. Each year, more than 300,000 people die from fire-related burn injuries and millions suffer from burn-related disabilities and disfigurements with psychological, social, and economic effects on both the survivors and their families. Dressing removal is reported to be the time of most pain (after the burn itself) and opioids continue to be the mainstay of treatment for the burn patient. The duration of a burn dressing change in a typical injury requiring ICU/OR level care is often at least 60 minutes with induction of general anesthesia, which can extend to more than three hours depending on the case. At present, all clinically approved available dressings adhere to the wound surface so that each change of dressing leads to traumatization of newly formed tissues on the outer layer of the body's surface, delayed healing, and great personal suffering for the injured patient. The application describes a thiol- terminated dendron and a bifunctional NHS-activated PEG that react with each other to form a thioester-linked hydrogel dressing that can be subsequently dissolved by exposure of an aqueous thiol solution via a thiol- thiolester exchange mechanism. The proposed experiments will test the hypothesis that a hydrogel- based, dissolvable burn dressing will provide a barrier to infection, promote wound healing, and be easily removable on demand. Importantly, it presents preliminary data demonstrating the synthesis, characterization, and performance of a dissolvable hydrogel dressing prototype. The specific aims of this four- year application are: Aim 1: Synthesize and characterize a series of hydrogel burn dressings; Aim 2: Determine the in vitro toxicity and biocompatibility, as well as in vivo compatibility after subcutaneous implantation of the dissolvable dressing; and Aim 3: Evaluate the efficacy of the dissolvable dressing in vivo.

描述：本申请描述了一种水凝胶敷料的合成、表征和评估，该敷料可以溶解并可以轻松地从二度烧伤患者的伤口表面去除，而不会造成进一步的创伤。烧伤是最常见和最具破坏性的创伤形式之一。据报道，每年有超过 30 万人死于与火灾相关的烧伤，数百万人遭受烧伤相关的残疾和毁容，对幸存者及其家人造成心理、社会和经济影响。最疼痛的时间（烧伤本身之后）和阿片类药物仍然是烧伤患者的主要治疗方法对于需要 ICU/OR 级别护理的典型损伤，烧伤敷料更换持续时间通常至少为 60 分钟（诱导）。全身麻醉的时间根据情况可以长达三个小时以上。目前，所有临床批准的可用敷料都粘附在伤口表面，因此每次更换敷料都会导致身体外层新生组织的创伤。表面、延迟愈合和该申请描述了一种硫醇封端的树突和一种双功能的 NHS 激活的 PEG，它们相互反应形成硫酯连接的水凝胶敷料，随后可以通过暴露于硫醇水溶液来溶解该敷料。硫醇-硫醇酯交换机制将验证基于水凝胶的可溶解烧伤敷料将提供感染屏障、促进伤口愈合并且易于去除的假设。重要的是，它提供了证明可溶性水凝胶敷料原型的合成、表征和性能的初步数据。这一为期四年的应用的具体目标是：目标 1：合成和表征一系列水凝胶烧伤敷料；确定可溶性敷料皮下植入后的体外毒性和生物相容性以及体内相容性；目标3：评价可溶性敷料的体内功效。