NICHD BREEDING COLONY

NICHD 繁殖群

• 批准号: 3742048
• 负责人: ANDREW G HENDRICKX
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3742048
• 关键词: Macaca mulatta; animal breeding; animal colony

This project's objective is to maintain a breeding colony of macaca mulatta and provide pregnancies of known gestational age and term infants as well as immature animals to NICHD funded investigators. A secondary goal is to provide breeding stock for future research programs. The colony now includes a total of 243 animals, 113 adults in the indoor time-mated colony, 40 adults in the field cage, 28 juveniles and infants in the field cage, 59 animals in corn cribs and 2 infants/juveniles in the indoor colony currently being weaned. In 1994 the conception rate was 78.23%, Prenatal mortality rate from resorptions, abortions and stillbirths was 15.53%; Infant and adult mortality rates were 9.84% And 5.31%, Respectively. 36 Animals were loaned to investigators. 62.78% Of the adult animals are housed in the indoor time-mated breeding program. Surplus immature juveniles are reared in group cages outdoors until sexual maturity, then they are recycled into the indoor time-mated program. Continued efforts to enhance postnatal development via prenatal (intrauterine) treatment with epidermal growth factor (EGF) have been pursued; significant effects on premature infant lung and gut development has been shown by collaborating scientists. Additionally, transplantation of hematopoietic stem cells prenatally has proven effective for establishing stable nonhuman primate chimeras in the absence of graft-versus-host disease. Further applications of ultrasound have been applied and successfully eliminated the need for extensive surgical procedures. Studies designed to elucidate the mechanisms of action of epidermal growth factor (EGF) on lung in prematurely delivered rhesus monkeys suggest that it may be useful in the treatment of human babies with respiratory distress syndrome. Data also suggest that a combined egf/surfactant treatment regimen may be superior to treatment with surfactant alone.

该项目的目标是维持麦卡卡的繁殖殖民地 穆拉塔（Mulatta）并提供已知的胎龄和期限婴儿的怀孕 以及未成熟的动物对NICHD资助的研究人员。 次要 目标是为未来的研究计划提供育种库存。 这 现在的殖民地现在包括243只动物，室内113只成人 时间融合的殖民地，40名田间笼子里的成年人，28名少年和婴儿 在野外笼子里，玉米婴儿床中的59只动物和2个婴儿/少年 目前断奶的室内殖民地。 1994年的构想率 为78.23％，产前死亡率，堕胎和 死胎是15.53％；婴儿和成人死亡率为9.84％，并且 分别为5.31％。 36只动物借给了调查人员。 62.78％ 成年动物的室内繁殖 程序。 多余的未成熟少年在户外饲养 直到性成熟为止，然后将它们回收到室内时间融合 程序。 继续努力通过产前增强产后发展 （宫内）表皮生长因子（EGF）的治疗已有 追捕；对早产肺和肠发展的重大影响 合作的科学家已经表明。 此外， 造血干细胞的移植已被证明 在建立稳定的非人类灵长类动物嵌合体中有效 缺乏移植物与宿主疾病。 超声的进一步应用 已应用并成功地消除了广泛的需求 手术程序。 旨在阐明机制的研究 表皮生长因子（EGF）对肺过早递送的作用 恒河猴表明它可能对人类的治疗有用 患有呼吸窘迫综合征的婴儿。数据还表明 EGF/表面活性剂治疗方案可能优于治疗 单独使用表面活性剂。