Craniofacial Diseases and Solutions in Man and Animals

人和动物的颅面疾病及解决方案

基本信息

批准号：
9261177
负责人：
Alireza Moshaverinia
金额：
$ 0.8万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-05 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9261177
关键词：
Animal Model Animals Area Basic Science Biomedical Engineering Clinical Clinical Engineering Clinical Trials Collaborations Data Dentistry Dentists Development Devices Diet Discipline Disease Disease model Domestic Animals Environment Evaluation Exhibits Failure Future Genetic Habits Human Inbreeding Information Resources Investigation Laboratory Animals Lead Life Link Medicine Modality Modeling Mus Pathway interactions Patients Pharmaceutical Preparations Physicians Regenerative Medicine Regimen Research Research Personnel Resources Rodent Diseases Science Scientist Testing Time Tissue Engineering Translational Research Veterinary Medicine Vision Work abstracting clinical efficacy clinically relevant companion animal comparative craniofacial craniomaxillofacial crosslink genetic manipulation genome editing human disease innovation invention man minimally invasive next generation novel therapeutics outcome prediction pre-clinical pre-clinical research preclinical study programs public health relevance symposium translational medicine translational study

项目摘要

Abstract There is an urgent need to increase translatability of scientific discoveries to sustainable novel therapeutics. However, as the limited translational significance of induced models of disease in laboratory animals is being recognized, critical evaluation of the clinical relevance of naturally occurring diseases in domestic animals is warranted. The proposed conference, will be first of its kind, and will elaborate on comparative aspects of naturally occurring craniomaxillofacial diseases in domestic animals, similar disorders in humans as well as ongoing and future research that may combine several disciplines. The speakers and attendees will create a unique platform that will cross - fertilize and cross – link between veterinary and human physicians, tissue engineers and basic and translational scientists. The audience will have the opportunity to participate in critical evaluation of current research in craniofacial disorders and solutions in man and animals as well as its benefits and shortcomings. Here, we propose that current research lacks appreciation to naturally occurring diseases in domestic animals as this research is under-investigated and under-utilized resource that could serve as a logical bridge between genetic and induced models of disease in laboratory animals and human clinical trials. The speakers and attendees will be exposed to vast and advanced research and broaden the horizon for future collaboration. Specifically, we will identify naturally occurring diseases in domestic animals that have the defining attributes of similar, if not identical, diseases in humans, and holds promise for providing predictive proof of concept in the evaluation of novel therapeutics and devices. Finally, we will work on a roadmap for the realization of this vision.

抽象的迫切需要提高科学发现转化为可持续小说的能力然而，由于诱导疾病模型的转化意义有限。实验动物正在被认可，对自然的临床相关性进行严格评估拟议的会议将是第一次此类会议，并将详细阐述自然发生的颅颌面疾病的比较方面家畜、人类的类似疾病以及正在进行和未来的研究可能会演讲者和与会者将结合多个学科，创建一个独特的跨学科平台。 - 兽医和人类医生、组织工程师以及基础和医学之间的交流和交流观众将有机会参与对转化科学家的批判性评估。当前对人类和动物颅面疾病和解决方案的研究及其益处和在此，我们提出当前的研究缺乏对自然发生的认识。家畜疾病，因为这项研究调查不足且资源利用不足可以作为实验动物遗传模型和诱导疾病模型之间的逻辑桥梁演讲者和与会者将接触到大量先进的研究。具体来说，我们将识别自然发生的家畜疾病具有与家畜疾病相似（即使不相同）的定义属性人类，并有望在小说评估中提供预测概念证明最后，我们将制定实现这一愿景的路线图。