NEUROPHYSIOLOGY OF PAIN ADAPTATION AND HYPERALGESIA

疼痛适应和痛觉过敏的神经生理学

• 批准号: 2262665
• 负责人: ROBERT H LA MOTTE
• 金额: $ 25.32万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2262665
• 关键词: C fiber; Cercopithecidae; Macaca fascicularis; capsaicin; chemical stimulation; chemoreceptors; cutaneous sensory nerve; dorsal horn; electronic stimulator; electrophysiology; evoked potentials; heat stimulus; histamine; human subject; human tissue; hyperalgesia; laboratory rat; mechanical pressure; mechanoreceptors; neural conduction; pain; pain threshold; pruritis; psychophysics; sensory disorders; sensory feedback; sensory receptors; sensory thresholds; stimulus /response; touch

Psychophysical measurements will be made in humans of the absolute thresholds and magnitude scaling functions for pricking and aching pain using punctate probes of different shapes indented into the skin and of "abrasive" pain using textured surfaces consisting of raised dots of different heights and spacing stroked across the skin. A less intense variety of similar stimuli will be used to measure itch. These measurements will be obtained for normal skin and for two types of cutaneous dysesthesia: secondary hyperalgesia (in skin surrounding an intradermal injection of capsaicin) and secondary "hyperknesia" (itchy skin) surrounding an intradermal injection of histamine. Evoked responses to the same cutaneous stimuli will be recorded electrophysiologically in single low threshold and nociceptive peripheral nerve fibers in vivo from anesthetized monkeys and in vitro from skin-nerve preparations from rat, monkey and human. In other experiments, evoked responses to the same stimuli will be recorded in single identified low-threshold and nociceptive neurons in the dorsal horn of the spinal cord in anesthetized monkeys. Correlating the discharges of single neurons in animals with sensory measures of pain or itch in humans will reveal the peripheral and central neuronal processes contributing to normal mechanically evoked pain and to the dysesthesias to mechanical stimuli that can develop with cutaneous injuries or peripheral nerve disorders.

心理物理测量将在绝对的人类中进行 阈值和幅度缩放功能，可刺痛和疼痛 使用缩进皮肤和皮肤的各种形状的点状探针 使用纹理表面的“磨蚀性”疼痛，由凸起的点组成 不同的高度和间距都穿过皮肤。 不太强烈 各种类似的刺激将用于测量瘙痒。 这些 将获得正常皮肤和两种类型的测量 皮肤异常：继发性痛觉过敏（在周围的皮肤中 皮内注射辣椒素）和次级“大奈斯氏症”（发痒 皮肤）围绕组胺的皮内注射。 将记录对同一皮肤刺激的诱发反应 在单个低阈值和伤害性周围的电生理学上 来自麻醉猴子的体内神经纤维和皮肤的体外 来自老鼠，猴子和人类的准备工作。 在其他实验中，唤起了 对同一刺激的响应将记录在单一的鉴定中 脊髓背角的低阈值和伤害性神经元 在麻醉的猴子中。 将单个神经元的放电相关联 具有感官疼痛或人类瘙痒的动物将揭示 外围和中央神经元过程有助于正常 机械诱发的疼痛和发抖，以至于机械刺激 可以因皮肤损伤或周围神经疾病而发展。