FLUOXETINE EFFECTS ON MOOD, COGNITION AND METABOLISM

氟西汀对情绪、认知和代谢的影响

• 批准号: 2248967
• 负责人: Helen S Mayberg
• 金额: $ 10.1万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2248967
• 关键词: Parkinson's disease; brain mapping; brain metabolism; caudate nucleus; cognition disorders; depression; frontal lobe /cortex; glucose metabolism; human subject; interview; mental disorder chemotherapy; mood disorders; neurochemistry; performance; positron emission tomography; psychopharmacology; serotonin inhibitor

Depressive disorders are common in patients with Parkinson's disease (PD), affecting as many as half of a cross sectional sample of patients. Notwithstanding the selective and often subtle cognitive deficits previously identified in PD, there are substantive differences in cognitive performance between patients who are depressed and those who are not. It is widely accepted that depression will decrease motivation and attention, thereby impairing performance on many cognitive tasks. It has only recently been proposed that depression selectively impairs performance on tasks classically considered to localize to the frontal lobes. This clinical association in PD of depression and selective cognitive deficits may implicate common neurochemical and neuroanatomical pathways. This study proposes to examine the interaction between changes in regional glucose metabolism, mood, and cognitive function in depressed PD patients treated with the selective serotonin uptake blocker, Fluoxetine. The hypothesis is that mood is well as specific cognitive deficits will improve following treatment with Fluoxetine. Furthermore, specific regional changes in brain glucose metabolism will occur, and will predict clinical improvement in mood state and cognitive performance. This study, using a multidisciplinary design, will focus on the specific interactions between brain chemistry, anatomy, and behavior relevant to the depression identified in patients with PD. To this end, the proposed studies will determine: (1) whether measurements of regional glucose metabolism are a specific marker of depressive state or trait in patients with PD, (2) whether improved performance on some, but not all cognitive tasks accompanies resolution of depressive symptoms, and (3) whether distinct patterns of regional glucose metabolism identify brain regions associated with depression-sensitive and depression-independent cognitive functions. This proposal would be a first step in the mapping of specific anatomical and neurochemical pathways involved in the genesis and recovery from depressive illness in patients with PD.

抑郁症在帕金森氏病（PD）的患者中很常见， 影响患者的横截面样本中多达一半。 尽管有选择性且经常微妙的认知缺陷 以前在PD中鉴定出来的认知存在实质性差异 沮丧的患者与不沮丧的患者之间的表现。 它 人们广泛认为抑郁会减少动力和关注， 从而损害许多认知任务的表现。 它只有 最近有人提出抑郁症有选择地损害了绩效 经典的任务被考虑到额叶的本地化。 这 抑郁症和选择性认知缺陷的临床关联 可能暗示着常见的神经化学和神经解剖学途径。 这项研究建议检查区域变化之间的相互作用 抑郁的PD患者的葡萄糖代谢，情绪和认知功能 用选择性5-羟色胺摄取阻滞剂氟西汀处理。 这 假设是心情和特定的认知缺陷会改善 用氟西汀治疗后。 此外，特定区域 脑葡萄糖代谢的变化将发生，并将预测临床 情绪状态和认知表现的改善。 这项研究，使用 多学科设计，将重点关注 大脑化学，解剖学和与抑郁有关的行为 在PD患者中鉴定。 为此，拟议的研究将 确定：（1）区域葡萄糖代谢的测量是否是一种 PD患者的抑郁状态或性状的特定标记，（2） 是否改善了某些（但不是所有认知任务）的表现 伴随抑郁症状的分辨率，以及（3）是否明显 区域葡萄糖代谢的模式鉴定与大脑区域相关的大脑区域 具有抑郁敏感和抑郁症的认知功能。 该建议将是特定解剖学映射的第一步 以及从起源和恢复中涉及的神经化学途径 PD患者的抑郁疾病。