MODELS FOR TREATING HIGH BLOOD CHOLESTEROL

治疗高胆固醇的模型

基本信息

批准号：
2221351
负责人：
ARLENE W CAGGIULA
金额：
$ 24.31万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1989
资助国家：
美国
起止时间：
1989-09-30 至 1995-07-31
项目状态：
已结题

项目摘要

In order to fully and effectively implement the guidelines of the National Cholesterol Education Program's Adult Treatment Guidelines, models for implementation within physicians office practices must be designed, tested, and evaluated for cost/effectiveness. This study has been designed to compare the efficacy of three implementation models in two phases: Model 1, Basic office based implementation (Phase 1); Model 2, Office assisted implementation and Model 3, Basic office based implementation plus an inclusive nutritional/ behavioral intervention offered through a community nutrition center. Practices will be randomized after Phase 1 into two conditions in order to test Models 2 and 3. Model 1 will serve as a control group for the other two models and will also provide information on patient eligibility, recruitment patterns and accrual rates. Cholesterol response after 3 months of intervention will be the primary end-point although patients will be followed in Phase 2 for up to two years in order to determine long-term cholesterol response, patterns of drug therapy as well as effectiveness of drug therapy, and drop out rates. The cost/effectiveness of each of the models will be calculated. Twenty physician practices will be recruited from a group of thirty practices already identified in the greater Pittsburgh area. Each practice will accrue at least 40 patients who will be treated according to the NCEP, ATP guidelines. The results of this study will provide important information as to the number of patients who will be willing to enter therapy, the number who will successfully lower their blood cholesterol levels by dietary approaches alone, and the number who will require drug therapy and the response to this therapy. Finally, we will be able to determine the cost/effectiveness of each approach.

为了充分有效地实施国家胆固醇教育计划的成人治疗指南，在医师办公室实践中实施的模型必须是设计，测试和评估成本/有效性。这项研究旨在比较三个的功效在两个阶段的实施模型：模型1，基于办公室的基础实施（第1阶段）；模型2，办公室协助实施和模型3，基于办公室的实施以及包容性通过社区提供的营养/行为干预营养中心。练习将在第1阶段之后随机分为两个为了测试模型2和3。模型1将作为一个其他两个模型的对照组，还将提供信息关于患者的资格，招聘模式和应计率。干预3个月后的胆固醇反应将是主要的终点，尽管将在第2阶段遵循最多两个患者为了确定长期胆固醇反应的年份药物治疗以及药物治疗的有效性，并退出费率。将计算每个模型的成本/有效性。将从三十组招募二十个医师练习大匹兹堡地区已经确定的实践。每个练习将至少有40名将接受治疗的患者到NCEP，ATP指南。这项研究的结果将提供有关愿意的患者人数的重要信息要进入治疗，将成功降低血液的人数胆固醇水平仅通过饮食方法，而人数需要药物疗法和对这种疗法的反应。最后，我们会的能够确定每种方法的成本/有效性。