DEPRESSION AND PROGRESSION OF HIV IN TANZANIAN WOMEN

坦桑尼亚妇女的抑郁症和艾滋病毒进展

• 批准号: 2445574
• 负责人: Mary Catherine Smith Fawzi
• 金额: $ 5.78万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2445574
• 关键词: AIDS /HIV test; African; HIV infections; clinical research; depression; female; human subject; pathologic process; psychoneuroimmunology; quality of life; social adjustment

DESCRIPTION (Adapted from applicant's abstract): Preliminary information on the relationship between HIV and depression is available largely from developed countries. Most ofthese studies have been conducted among homosexual/bisexual men in the U.S. and there is even less information on this association among women in developing countries. The WHO neuropsychiatric AIDS study observer a higher mean depression score for those with symptomatic HIV compared with an HIV seronegative group. Given the preliminary nature of this cross-section analysis, it is unclear whether depressive symptoms resulted from HIV-related symptomatology or if depressive symptoms facilitated the progression of HIV infection. In order to assess the temporal sequence of HIV-related symptoms and depression, this association will be examined within the context of a prospective study among HIV-positive women in Tanzania. This study of depressive symptoms will be nested within a larger study in which the main objective is to determine whether the oral administration of vitamin supplements during and after pregnancy reduces the risk of perinatal transmission of HIV; a secondary objective is to determine whether the vitamin supplements slow the rate of progression of HIV in this population. The aims for the proposed sub-study are as follow: 1) To determine if depressive symptomatology among HIV-positive women at baseline is associated with faster progression of HIV, poorer quality of life, and greater disability at follow-up; 2) To assess the occurrence of HIV-related symptoms and negative social consequences of HIV-test result notification, such as domestic violence, at baseline in relation to depressive symptoms at follow-up; 3) To examine the association between HIV serostatus notification and the occurrence of depressive symptoms; 4) To validate depression screening measures for use in Tanzania. This study will provide preliminary information on the association between HIV and depression among women in Tanzania and will potentially be the basis for future studies examining the effect of relevant therapeutic interventions (e.g. individual counselling, social support groups) on the quality of life and survival of individuals with HIV. Identifying modifiable factors, such as depression, that improve survival is particularly important for developing countries where access to zidovudine is limited and progression to AIDS occurs more rapidly. This study is also the first systematic assessment of the occurrence of potentially negative consequences of HIV antibody testing in Tanzania, possibly contributing to the public health information available to policy-makers who are examining the relative risks/benefits of providing wider accessibility of HIV testing in Sub-saharan Africa.

描述（改编自申请人的摘要）：有关的初步信息 艾滋病毒与抑郁之间的关系主要来自 发达国家。 这些研究大多数是在 在美国的同性恋/双性恋男人，有关的信息甚至更少 发展中国家妇女之间的这种联系。 WHO 神经精神艾滋病研究观察者的平均抑郁评分较高 患有症状HIV的患者与HIV血清负格组相比。 给出 这种横截面分析的初步性质，目前尚不清楚是否清楚 抑郁症状是由HIV相关症状引起的，或 抑郁症状促进了HIV感染的进展。 为了评估HIV相关症状的时间顺序和 抑郁症，将在 坦桑尼亚的HIV阳性女性的前瞻性研究。 这项研究 抑郁症状将嵌套在更大的研究中 目的是确定维生素的口服服用是否 怀孕期间和之后的补充剂降低了围产期的风险 艾滋病毒的传播；次要目标是确定是否 维生素补充剂减缓了该人群中HIV的进展速度。 提议的子研究的目的如下：1）确定是否是否 基线时，HIV阳性女性的抑郁症状与 艾滋病毒的进展更快，生活质量较差和更大 随访时残疾； 2）评估与HIV相关症状的发生 以及艾滋病毒测试结果通知的负面社会后果，例如 家庭暴力，基线与抑郁症状有关 随访； 3）检查HIV血清静脉通知之间的关联 以及抑郁症状的发生； 4）验证抑郁症 在坦桑尼亚使用的筛查措施。 这项研究将提供初步 妇女中艾滋病毒与抑郁之间的关联的信息 坦桑尼亚，有可能成为未来研究的基础 相关治疗干预措施的影响（例如，个人咨询， 社会支持小组）关于个人的生活质量和生存 与艾滋病毒。 确定改善的可修改因素，例如抑郁症 生存对于进入的发展中国家尤其重要 Zidovudine受到限制，进展到艾滋病的进展更快。 这 研究也是对发生的首次系统评估 坦桑尼亚HIV抗体测试的潜在负面后果， 可能为可用的公共卫生信息做出贡献 正在研究提供相对风险/收益的政策制定者 撒哈拉以南非洲艾滋病毒测试的更广泛可及性。

项目成果

The association between maternal HIV-1 infection and pregnancy outcomes in Dar es Salaam, Tanzania.

坦桑尼亚达累斯萨拉姆孕产妇 HIV-1 感染与妊娠结局之间的关联。

• DOI: 10.1111/j.1471-0528.2003.00269.x
• 发表时间: 2001
• 期刊: BJOG : an international journal of obstetrics and gynaecology
• 作者: Coley,JL;Msamanga,GI;Fawzi,MC;Kaaya,S;Hertzmark,E;Kapiga,S;Spiegelman,D;Hunter,D;Fawzi,WW
• 通讯作者: Fawzi,WW