PROGESTERONE REGULATION OF SOCIOSEXUAL BEHAVIOR IN MALES

黄体酮对男性社会性行为的调节

• 批准号: 2439006
• 负责人: DIANE M WITT
• 金额: $ 3.75万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2439006
• 关键词: Animalia; behavioral /social science research tag; hormone regulation /control mechanism; male; progesterone; sex behavior; social behavior

In females, it is well documented that progesterone (P) differentially affects specific limbic nuclei and related hypothalamic nuclei that regulate sociosexual behavior either by acting through genomic and/or non- genomic cellular mechanisms. However, for males there is limited knowledge on the functional and cellular aspects of this gonadal/ adrenal hormone. Prior research has shown that at pharmacological levels P possesses antiandrogenic properties that inhibit masculine reproductive behavior, but more recent studies in male rats and lizards have challenged the dogma that P attenuates reproductive behavior by antiandrogenic actions. These recent experiments have provided new evidence that at physiological levels P can actually facilitate aspects of copulatory behavior in gonadectomized males even in the absence of androgen replacement therapy. Furthermore, the P receptor antagonist RU486 reduces mating behavior in gonadally intact males, suggesting that P has a synergistic relationship with androgens that enhances reproductive behavior in males. The present studies will re-evaluate progesterone's role in the expression of male reproductive processes by neuroanatomically localizing the regions involved in P-mediated behavioral responses in males by intrahypothalamic microinjection of P (low levels) or RU486 (to block endogenous P receptors) in males primed with physiological levels of androgen. Subsequent studies will determine whether P-dependent behavioral responses are differentially regulated via genomic or non-genomic mechanisms by observing the rapid effect of microinjections (in select neuroanatomic sites) of P conjugated to bovine serum albumin (P-BSA). P-BSA does not diffuse freely through plasma membranes, binds specifically to plasma membranes, and triggers cellular responses to steroids within minutes. P's actions remain unclear in humans, yet, progestin therapy is used routinely as a means to control libido in felony sex offenders. The information derived from experiments in this proposal is fundamental to our understanding of the neurochemical pathways and cellular mechanisms underlying normal sociosexual behavior as well as deciphering pathological conditions associated with neuroendocrine dysfunction.

在女性中，有充分证据表明孕酮 (P) 存在差异 影响特定的边缘核和相关的下丘脑核 通过基因组和/或非基因组来调节社会性行为 基因组细胞机制。但对于男性来说，知识有限 关于这种性腺/肾上腺激素的功能和细胞方面。 先前的研究表明，在药理学水平上，P 具有 抑制男性生殖行为的抗雄激素特性， 但最近对雄性老鼠和蜥蜴的研究挑战了这一教条 P 通过抗雄激素作用减弱生殖行为。这些 最近的实验提供了新的证据，表明在生理水平上 P实际上可以促进性腺切除的交配行为的各个方面 即使在没有雄激素替代治疗的情况下，男性也会出现这种情况。此外， P 受体拮抗剂 RU486 减少性腺的交配行为 完整的雄性，表明 P 与 增强男性生殖行为的雄激素。现在的 研究将重新评估黄体酮在男性表达中的作用 通过神经解剖学定位区域的生殖过程 通过下丘脑内参与 P 介导的男性行为反应 显微注射 P（低水平）或 RU486（以阻断内源性 P 受体）在男性中引发了生理水平的雄激素。 后续研究将确定 P 依赖性行为反应是否 通过基因组或非基因组机制进行差异调节 观察显微注射的快速效果（在选定的神经解剖学中） P 与牛血清白蛋白 (P-BSA) 结合的位点）。 P-BSA 不 通过质膜自由扩散，与血浆特异性结合 细胞膜，并在几分钟内触发细胞对类固醇的反应。 P的 对人类的作用尚不清楚，但孕激素疗法已被常规使用 作为控制重罪性犯罪者性欲的一种手段。信息 从该提案中的实验得出的结论对于我们来说至关重要 了解神经化学途径和细胞机制 潜在的正常社会性行为以及破译病理性行为 与神经内分泌功能障碍相关的病症。

项目成果

Testosterone and sexual experience alter levels of plasma membrane binding sites for progesterone in the male rat brain.

睾酮和性经历改变雄性大鼠大脑中黄体酮质膜结合位点的水平。

• DOI: 10.1055/s-2003-39060
• 发表时间: 2003
• 期刊: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
• 作者: Witt,DM;Gao,G;Caldwell,JD
• 通讯作者: Caldwell,JD