REDOX CHEMISTRIES OF SOME EFFECTIVE ANTIVIRAL AGENTS

一些有效抗病毒药物的氧化还原化学

• 批准号: 2519062
• 负责人: SADIQ H WASFI
• 金额: $ 15.86万
• 依托单位: DELAWARE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-01 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519062
• 关键词: X ray crystallography; acidity /alkalinity; anions; antiAIDS agent; antiviral agents; chemical property; chemical synthesis; drug screening /evaluation; human immunodeficiency virus; infrared spectrometry; molecular size; oxidation reduction reaction; reverse transcriptase inhibitors; spectrometry; water solution

The principal objective of the proposed study is to determine the redox chemistries of some heteropolyoxo- and oxofluoro- metalate anions that have been shown to be effective in vitro antiviral agents. The reduction potentials of these anions will be determined by recording the cyclic voltammograms of these anions in aqueous solutions of different pH values. Distorted Dawson structure anions with the general formula [x+xW17O56F6NaH4]-(11-X) have been prepared, characterized, and the antiviral activity has been determined, where X = co+2, Co+3, Cu+, Cu+2, Zn+2, Mn+2, Mn+3, Mg+2, Fe+2, and Fe+3. The study will also include the preparation, characterization and the determination of the antiviral activities of analogous anions where X = Ga+3, In+3, A1+3, and Sc+3. This appears to be feasible because of comparable ionic sizes. The study will also include some heteropoly anions that have the Keggin structure or a distorted Keggin structure. We will also isolate the reduced products, "Heteropoly Blues", which result from electrolysis at constant potential. These new products will be tested for their antiviral activity. It is believed that there are three main reasons why heteropoly anions are effective antiviral agents: ionic size and shape, electron transfer and storage properties, and composition. We are convinced that the above study will help determine if the redox properties are the most influential in making an effective antiviral agent, and ultimately will help determine the mechanism by which these anions effectively combat the viral agents. This in turn will help us tailor an antiviral agent and test only those compounds with appropriate chemical properties.

拟议研究的主要目的是确定氧化还原 某些杂质和氧氟金属酸盐的化学作品 已证明在体外抗病毒剂有效。 减少 这些阴离子的电势将通过记录循环确定 这些阴离子在不同pH值的水溶液中的伏安图。 带有通用公式的Dawson结构扭曲的Dawson结构 [X+XW17O56F6NAH4] - （11-X）已被准备，表征，并且 已经确定了抗病毒活性，其中x = co+2，co+3，cu+，cu+2， Zn+2，Mn+2，Mn+3，mg+2，Fe+2和Fe+3。 该研究还将包括制备，表征和 确定类似阴离子的抗病毒活性，其中x = Ga+3，in+3，A1+3和SC+3。这似乎是可行的 可比的离子尺寸。 这项研究还将包括一些异位 具有Keggin结构或扭曲的Keggin结构的阴离子。 我们 还将隔离还原的产品“异位布鲁斯”，结果 从恒定电势的电解。 这些新产品将是 测试了其抗病毒活性。相信有三个 杂物阴离子是有效抗病毒药的主要原因：离子 尺寸和形状，电子传输和存储特性以及组成。 我们坚信上述研究将有助于确定氧化还原是否 特性是制造有效抗病毒的最具影响力 代理，最终将有助于确定这些机制 阴离子有效地对抗病毒剂。 这反过来将帮助我们 量身定制抗病毒剂，仅测试适当的化合物 化学特性。