DRUGS OF ABUSE--CHRONIC INTERACTIONS AND BEHAVIOR

滥用药物——长期相互作用和行为

• 批准号: 2012831
• 负责人: Donald McMillan
• 金额: $ 22.88万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-06-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2012831
• 关键词: central nervous system depressants; chronic disease /disorder; discrimination learning; drug abuse; drug interactions; laboratory rat; memory; pigeons; psychomotor function; psychopharmacology; reinforcer; species difference; stimulant /agonist

DESCRIPTION: (Applicant's Abstract) When an abused drug is self-administered it produces internal stimuli in the user of which the user is often aware. We refer to these effects in humans as the "subjective effects" of the drug. One way in which behavioral pharmacologists have studied these internal stimuli in animal models has been to establish them as discriminative stimuli. Responses can be scheduled to occur or not occur in the presence or absence of these internal drug stimuli by differentially reinforcing responding. These drug discrimination procedures have been used to study the behavioral consequences of a number of effects of drugs at the cellular level of the brain including receptor binding, neurotransmitter depletion, and many others. Despite the widespread usage of drug discrimination procedures, there are many questions about the procedure that have not been answered. For example, there are arguments about whether or not drug discrimination gradients are quantal or graded. It is not known if the discrimination between two different drugs differs from the discrimination between the presence and absence of a single drug. Although the experience of an organism with other drugs has been shown to be an important determinant of many drug effects, such historical factors have received little attention in drug-discrimination research. The ability of animals to learn complex drug discriminations has also received little attention and there are almost no studies in the literature that systematically compare the effects of drugs as discriminative stimuli with their effects on other behaviors. The proposed research would fill this gap by determining how reinforcement schedules and drug discrimination training history affect the discriminative stimulus properties of drugs. Experiments would also be conducted to develop new procedures for studying and interpreting complex drug discriminations and for comparing the effects of drugs as discriminative stimuli to their effects on animal models of anxiety, memory and other important behaviors. These experiments will provide fundamental new information about the drug discrimination process that should greatly add to our knowledge of how the stimulus properties of drugs contribute to their abuse.

描述：（申请人的摘要） 当滥用药物自我管理时，它会产生内部刺激 用户经常知道的用户。 我们指的是人类的影响 作为药物的“主观效应”。 行为的一种方式 药理学家已经研究了动物模型中的这些内部刺激 将它们确立为歧视性刺激。 可以做出回应 计划在存在或不存在这些内部的情况下发生或不发生 通过差异加强反应来刺激药物刺激。 这些药物 歧视程序已用于研究行为 药物在细胞水平上的多种作用的后果 包括受体结合，神经递质耗竭和许多大脑 其他的。 尽管药物歧视程序广泛使用，但 关于该过程的问题尚未得到回答。 例如，有关于毒品歧视的争论 梯度是数量或分级的。 尚不清楚歧视是否 两种不同的药物之间与歧视 存在和不存在一种药物。 虽然经验 与其他药物的有机体已被证明是重要的决定因素 许多药物影响，此类历史因素很少受到关注 药物歧视研究。 动物学习复杂药物的能力 歧视也很少受到关注，几乎没有 文献中的研究系统地比较了药物的作用 作为歧视性刺激，其对其他行为的影响。 这 拟议的研究将通过确定如何加强来填补这一空白 时间表和药物歧视培训历史影响歧视 药物的刺激特性。 实验也将进行 开发研究和解释复杂药物的新程序 歧视和将药物的影响作为歧视性 刺激它们对焦虑，记忆和其他动物模型的影响 重要的行为。 这些实验将提供基本的新 有关毒品歧视过程的信息，该过程应大大增加 我们了解药物的刺激特性如何有助于其 虐待。