Blood Flow Velocimetry Using Digital Subtraction Angiography

使用数字减影血管造影进行血流速度测量

基本信息

批准号：
9137447
负责人：
BIPIN SINGH
金额：
$ 22.5万
依托单位：
RADIATION MONITORING DEVICES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2017-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9137447
关键词：
Address Algorithms Aneurysm Area Arteriographies Arteriovenous malformation Back Behavior Biological Blood Blood Flow Velocity Blood Pressure Blood Vessels Blood flow Cardiac Cardiovascular Diseases Cerebrovascular Disorders Cerebrovascular system Characteristics Clinical Code Complex Data Storage and Retrieval Developed Countries Development Diagnosis Diagnostic Diagnostic radiologic examination Digital Subtraction Angiography Disease Dose Economics Ensure Evolution Failure Geometry Goals Health Healthcare Human Human Resources Image Imaging Techniques Investments Knowledge Lead Light Liquid substance Magnetic Resonance Imaging Maps Measurement Measures Mechanical Stress Medical Medical Imaging Methods Mission Monitor Morbidity - disease rate Morphology Nature Noise Operative Surgical Procedures Optics Pathology Patients Penetration Perioperative Personal Satisfaction Phase Photons Physics Physiologic pulse Play Prevention Procedures Reading Research Research Personnel Resolution Risk Roentgen Rays Role Scientist Signal Transduction Son Source Stenosis Stress System Techniques Technology Testing Therapeutic Thick Time Ultrasonography Universities Validation Vascular Diseases Vascular System Velocimetries Work Yang absorption artery occlusion brain arteriovenous malformations cerebrovascular clinical Diagnosis clinical application computer code cost cost effective design detector experience hemodynamics image processing imaging detector imaging system improved in vivo innovation interest knowledge base meetings mortality new technology novel operation particle prevent programs public health relevance shear stress simulation temporal measurement tool treatment planning

项目摘要

DESCRIPTION (provided by applicant): Diseases in the vascular system are still the leading cause of mortality and morbidity in developed countries despite considerable therapeutic progress in recent years. Blood flow velocity provides critical information needed for the diagnosis of vascular diseases, planning of interventional surgery treatment, and monitoring of endovascular treatment of brain arteriovenous malformations. The lack of such flow characteristics prevents understanding the underlying hemodynamics and its correlation with multiple cerebrovascular diseases. Therefore, there is a critical need to obtain precise blood flow velocities in the vascular system, which can be used to estimate the blood pressure, wall shear stress on the arterial wall and other hemodynamic indicators, and aid in diagnosing and treating a host of vascular diseases. Current diagnostic tools suffer from poor accuracy or low spatial and temporal resolutions. To overcome this limitation, we propose to develop an ultrafast, high-resolution X-ray blood flow velocimetry system that will provide quantitative blood velocity maps in the endovascular system. Furthermore, researchers using numerical simulations to understand the hemodynamics desperately seek detailed blood velocity and stress measurements for comparison and validation of their computer codes. The proposed project aims at providing a novel blood flow velocimetry tool using an ultrafast X-ray probing and inexpensive digital subtraction angiography (DSA) that can recover precise velocity distribution inside of the vascular systems especially for complex geometries. The long-term goal of the proposed research is to provide critical blood flow characteristics in vascular systems allowing scientists to predict the formation, evolution and failure risk of vascular pathology such as arteriovenous malformations, arterial occlusions, stenosis, and aneurysms. The proposed technology has a great potential in generating a real-time perioperative assessment of the blood velocity during a DSA routine. The novel technology will enable medical scientists to gain more fundamental knowledge about the nature and behavior of hemodynamics in cerebrovascular systems. The project is highly relevant to NIH's mission because the precise real-time assessment of blood velocities will lead to more educated therapeutic decisions which could save more lives, improve health, and reduce operation cost. The expanded knowledge base will enhance the Nation's economic well-being and ensure a continued high return on the public investment in research.

描述（由申请人提供）：尽管近年来治疗取得了相当大的进展，但血管系统疾病仍然是发达国家死亡和发病的主要原因。血流速度为血管疾病的诊断、介入手术的规划提供了所需的关键信息。脑动静脉畸形的血管内治疗和监测缺乏这种血流特征阻碍了对潜在血流动力学及其与多种脑血管疾病的相关性的了解。血管系统中的血流速度，可用于估计血压、动脉壁上的壁剪切应力和其他血流动力学指标，并有助于诊断和治疗许多血管疾病。为了克服这一限制，我们建议开发一种超快、高分辨率的 X 射线血流测速系统，该系统将提供定量的血液。此外，研究人员使用数值模拟来了解血流动力学，迫切需要详细的血流速度和压力测量，以对其计算机代码进行比较和验证。该项目旨在提供一种使用超快 X 的新型血流测速工具。射线探测和廉价的数字减影血管造影（DSA）可以恢复血管系统内部的精确速度分布，特别是对于复杂的几何形状。拟议研究的长期目标是提供血管系统中的关键血流特征，使科学家能够预测血管病理的形成、演变和失败风险，例如动静脉畸形、动脉闭塞、狭窄和动脉瘤。所提出的技术在 DSA 常规技术的围手术期实时评估方面具有巨大的潜力。使医学科学家能够获得有关脑血管系统血流动力学的性质和行为的更多基础知识该项目与 NIH 的使命高度相关，因为精确的实时评估。血流速度将导致更明智的治疗决策，从而挽救更多生命、改善健康并降低运营成本。扩大的知识库将增强国家的经济福祉，并确保公共研究投资持续获得高回报。