CTSA Supplement

CTSA 补充

• 批准号: 9250940
• 负责人: Allan R. Brasier
• 金额: $ 11.63万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-18 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9250940
• 关键词: Abbreviations; Academy; Accident and Emergency department; Address; Adopted; Advocacy; African American; Aging; Appointment; Area; Aromatic Polycyclic Hydrocarbons; Award; Bed Occupancy; Beds; Bioinformatics; Biological Sciences; Budgets; Burn injury; Caring; Catchment Area; Childhood; Clinic; Clinical; Clinical Research; Clinical Services; Clinical Trials; Communities; Community Health Education; Community Healthcare; Course Content; Day Surgery; Dengue; Development; Devices; Disasters; Discipline of Nursing; Diverse Workforce; Ebola virus; Education; Educational Curriculum; Entrepreneurship; Environment; Environmental Health; Environmental Medicine; Ethics; Evaluation; Faculty; Fostering; Frankfurt-Marburg Syndrome Virus; Funding; Funding Opportunities; Geriatrics; Goals; Good Clinical Practice; Grant; Growth; Health; Health Occupations; Health Personnel; Health Sciences; Health system; Healthcare; Hispanics; Historically Black Colleges and Universities; Home environment; Hospital Referrals; Hospitals; Human; Hybrids; Immunity; Impact evaluation; Individual; Industry; Infection; Inpatients; Institute of Medicine (U.S.); Institutes; Institution; Investments; Island; Knowledge; Laboratories; Latino; Leadership; Longitudinal Studies; Medical; Methods; Mission; Modeling; Molecular; Monitor; Multi-Institutional Clinical Trial; National Institute of Allergy and Infectious Disease; Oils; Outcome; Outcomes Research; Outpatients; Parasitic Diseases; Participant; Patient Admission; Patient Care; Patient-Focused Outcomes; Patients; Patients' Rooms; Pediatrics; Pharmacy facility; Phase; Population; Positioning Attribute; Pregnancy; Process; Public Policy; Publishing; Puerto Rico; Radial; Recommendation; Reporting; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resource Sharing; Resources; Role; Satellite Hospitals; Schedule; Schools; Science; Scientist; Services; Site; Special Populations Research; Staging; Students; System; Teaching Hospitals; Testing; Texas; Therapeutic; Training; Training Support; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Vaccines; Viral Hemorrhagic Fevers; Virus Diseases; Vision; Visit; Wages; Wing; Work; Workforce Development; abstracting; base; bed capacity; bench to bedside; career; cohort; collaborative environment; commercialization; community based participatory research; comparative effectiveness; data sharing; effectiveness research; evidence base; experience; gulf coast; implementation research; improved; innovation; inter-institutional; interest; leadership development; learning community; medical schools; medical specialties; member; multidisciplinary; named group; novel; novel diagnostics; novel strategies; outreach; pathogen; patient advocacy group; patient population; programs; quality assurance; research clinical testing; research facility; response; science education; skills; square foot; tertiary care; therapeutic vaccine; tool; translational study; trauma centers; vaccine development; working group

Contact PD/PI: Brasier, Allan R. The CTSA at the University of Texas Medical Branch (UTMB) is located within the Institute for Translational Science (ITS), one of three free-standing UTMB institutes, established in 2007. In its role as the home for clinical and translational research, the ITS provides primary tenure-earning faculty appointments to 7 early- career translational scientists. Over the past 5½ years, we have transformed UTMB's research culture, growing from an institution that solely valued individual laboratory-oriented research to one that embraces multidisciplinary translational team (MTT) approaches to addressing significant health problems. We have developed novel educational curricula, significant clinical research programs in special populations with multi- site clinical trials (CTs), and provided leadership in the Texas Regional CTSA consortium (TRCC) and nationally. The mission of the UTMB CTSA hub is to support the health goals of the nation by generating, testing and disseminating integrative team science, education and best practices through stakeholder involvement at all stages. Managed by a continuous improvement model using an Innovation Scorecard, the UTMB CTSA will address four specific aims, to: 1) Train a diverse workforce in the authentic skills needed to advance all phases of translational research. We have used the team environment as an educational framework to support the training of diverse learning communities. Our innovation, entrepreneurship, and team leadership curricula will be used to instill focused, career stage-appropriate competencies in our trainees. We have led in sharing and disseminating innovative educational content in entrepreneurship and team science throughout the consortium. 2). Engage stakeholders across all phases of translational research and CTs. We will extend our substantial bidirectional interactions with stakeholders from the community, patient advocacy groups, healthcare providers and our Health System to assess health needs, set CTSA priorities and disseminate competencies. 3). Integrate quality systems through all types of translational research, including CTs in special populations. We have provided leadership to a university-wide plan for sustainable support for high-quality CTs through the Office of Clinical Research, supported by an experienced director, an interoperable Clinical Trial Management System and staff to provide streamlined support for all phases of CT start-up, quality assurance monitoring, study management and GCP training. 4). Advance the conduct of translational research through MTT-based innovation. The UTMB CTSA hub is unique in the national consortium in its systematic application of a hybrid industry-academic MTT model, and have developed an evidence base on the formation, evaluation, impact and trajectories of successful MTTs. We will stimulate MTT innovation by promoting team development, leadership development by a unique Leadership Development Academy, and advancement of therapeutics and devices into Phase I/II CTs in our “Innovations in Molecular Therapeutics and Devices” Optional Module. Project Summary/Abstract Page 308 Contact PD/PI: Brasier, Allan R. Narrative The UTMB CTSA hub will support bidirectional translational research, moving discoveries from the bench to the bedside, by training a capable workforce using our unique multidisciplinary translational teams and innovative educational programs that build real-world skills. Our hub will serve to foster high-quality clinical research, develop best practices in team-based translations, participate in inter-institutional data-sharing, and function as an efficient site for multi-site clinical trials in understudied populations. In this manner, the UTMB CTSA hub will be an important contributor to achieving the goals of the national consortium.

联系人 PD/PI：Brasier, Allan R. 德克萨斯大学医学分部 (UTMB) 的 CTSA 位于转化研究所内 Science (ITS) 是三个独立的 UTMB 机构之一，成立于 2007 年。 临床和转化研究方面，ITS 为 7 名早期获得终身教职的教员提供了任命 在过去的 5.5 年里，我们改变了 UTMB 的研究文化，不断发展。 从一个只重视个人实验室导向研究的机构转变为一个包含 我们拥有解决重大健康问题的多学科转化团队 (MTT) 方法。 开发了新颖的教育课程，针对特殊人群的重要临床研究项目，具有多种 现场临床试验 (CT)，并在德克萨斯州地区 CTSA 联盟 (TRCC) 和 UTMB CTSA 中心的使命是通过以下方式支持国家的健康目标。 通过以下方式生成、测试和传播综合团队科学、教育和最佳实践 通过使用创新的持续改进模型来管理所有阶段的利益相关者参与。 根据记分卡，UTMB CTSA 将实现四个具体目标，即： 1) 在真实的环境中培训多元化的劳动力 推进转化研究各个阶段所需的技能我们利用团队环境作为一个平台。 支持多元化学习社区培训的教育框架。 创业和团队领导课程将用于灌输专注的、适合职业阶段的课程 我们在分享和传播创新教育内容方面发挥了主导作用。 整个联盟的创业精神和团队科学 2)。 我们将扩大与利益相关者的实质性双向互动。 来自社区、患者倡导团体、医疗保健提供者和我们的卫生系统的健康评估 需求，设定 CTSA 优先事项并传播能力 3)。 转化研究，包括特殊人群的 CT 研究，我们提供了领导。 通过临床研究办公室为高质量 CT 提供可持续支持的全校范围计划， 由经验丰富的主管、可互操作的临床试验管理系统和工作人员提供支持，以提供 简化对 CT 启动、质量保证监测、研究管理和 GCP 所有阶段的支持 4). 通过基于 MTT 的创新来推进转化研究。 CTSA 中心在行业-学术混合 MTT 的系统应用方面在国家联盟中是独一无二的 模型，并开发了关于形成、评估、影响和轨迹的证据基础 成功的 MTT。我们将通过促进团队发展、领导力发展来刺激 MTT 创新。 通过独特的领导力发展学院，并将疗法和设备推进到 I/II 期 我们的“分子治疗和设备创新”可选模块中的 CT。 项目总结/摘要第 308 页 联系人 PD/PI：Brasier, Allan R. 叙述 UTMB CTSA 中心将支持双向转化研究，将实验室的发现转移到实验室 在床边，通过使用我们独特的多学科翻译团队培训有能力的员工队伍， 我们的中心将致力于培养高质量的临床技能的创新教育计划。 研究、开发团队翻译的最佳实践、参与机构间数据共享，以及 通过这种方式，UTMB 成为在受研究人群中进行多中心临床试验的有效场所。 CTSA 中心将成为实现国家联盟目标的重要贡献者。