Exercising language: Behavioral and neurophysiological changes after high-intensity exercise training in post-stroke aphasia.

运动语言：中风后失语症高强度运动训练后的行为和神经生理变化。

• 批准号: 10862024
• 负责人: Maria V. Ivanova
• 金额: $ 71.25万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10862024
• 关键词: Adjuvant; Aerobic; Affect; Aftercare; Anxiety; Aphasia; Attention; Behavioral; Blood; Blood Vessels; Blood flow; Brain; Cerebrovascular Circulation; Cerebrum; Chronic; Clinical; Cognition; Cognitive; Comprehension; Dose; Effectiveness; Emotional; Evaluation; Exercise; Family; Friends; Gait; Health; Health Benefit; Individual; Intervention; Knowledge; Language; Language Disorders; Language Therapy; Lead; Learning; Life; Maintenance; Measures; Mediating; Memory; Mental Depression; Motor; Motor Skills; Names; Neuronal Plasticity; Outcome; Outcome Measure; Participant; Patients; Pattern; Performance; Perfusion; Personal Satisfaction; Persons; Physical Exercise; Physical Fitness; Physiological; Population; Production; Quality of life; Recovery; Speech; Stroke; Thinking; Treatment Protocols; Up-Regulation; Vascular blood supply; Well in self; Work; aphasia recovery; behavioral outcome; brain health; cardiorespiratory fitness; cerebrovascular; cognitive ability; cognitive benefits; cognitive enhancement; cognitive performance; cost efficient; design; executive function; exercise intensity; exercise intervention; exercise program; exercise training; fitness; improved; innovation; insight; language outcome; motor recovery; nervous system disorder; neural; neuroimaging; neurophysiology; neurovascular; novel; novel strategies; physical conditioning; post intervention; programs; psychologic; psychosocial; recruit; response; skills; sleep quality; social engagement; stroke survivor; stroke-induced aphasia; tool; traditional therapy

Project Summary/Abstract Losing the ability to speak and understand language is devastating for patients with aphasia and their families, negatively impacting multiple aspects of life and emotional well-being. Unfortunately, individuals with aphasia rarely regain their language skills in full. Novel approaches are required that boost the effects of traditional therapies, leading to better outcomes for people with aphasia. The proposed study seeks to evaluate the effects of a promising adjuvant intervention - physical exercise training - on recovery in aphasia. A new exercise program, specifically designed for individuals with post-stroke aphasia, will be the means of providing a safe, stroke- and aphasia-friendly physical exercise intervention to achieve optimal physical fitness gains. This will also be the first large scale study in aphasia to systematically examine the additive and enhancing effects of combining physical exercise training with traditional language therapy. Innovative outcome measures will include not only language and cognitive measures but also measures of motor skills and psychological and psychosocial outcomes that will assess the benefits of physical exercise. Another cutting-edge aspect of the study is the inclusion of advanced physiological fitness measures and neuroimaging metrics of blood flow and cerebrovascular reactivity as outcome measures to afford a deeper understanding of the exercise-mediated behavioral and neural effects in stroke survivors. We will recruit 110 individuals with aphasia to evaluate the multifaceted impact of exercise on behavioral and physical outcomes in isolation and in combination with traditional speech-language therapy. First, the benefits of physical exercise for language, cognition, motor, and emotional and psychological well-being in individuals with aphasia will be established. Of particular importance will be an enhanced understanding of how exercise can boost the effects of existing speech-language therapies. Second, determining how exercise-induced changes in physical fitness are related to changes in language and cognitive measures will provide insight into key ingredients of successful exercise interventions. Third, evaluation of the exercise-induced neurovascular changes that relate to behavioral improvements, as measured with novel blood supply neuroimaging tools, will advance our knowledge about the brain mechanisms of the observed cognitive benefits. Finally, the validated physical exercise intervention, resulting from this project, will offer a new tool to clinicians seeking to help individuals with aphasia, either as a free-standing program to enhance physical health, cognition, and well-being, or as an adjunct therapy to standard speech-language therapy. Ultimately, this work could significantly alter our thinking about adjuvant aphasia therapies that can benefit those affected by stroke and aphasia through non- traditional means, in this case, a promising, safe, and cost-efficient adjunct intervention that can enhance all levels of functioning from general health to language to social engagement.

项目摘要/摘要 失去说话和理解语言的能力对于失语症及其患者而言是毁灭性的 家庭，对生活的多个方面和情感幸福感产生负面影响。不幸的是，有个人 失语症很少能全面恢复他们的语言技能。需要采取新颖的方法来增强 传统疗法，为失语症患者带来更好的结果。 拟议的研究旨在评估有希望的佐剂干预的影响 - 体育锻炼 培训 - 关于失语症的康复。一个新的练习计划，专为中风的个人而设计 失语症将成为提供安全，中风和失语症的体育锻炼干预措施的手段 实现最佳的身体健康增长。这也将是第一个大规模研究，以进行系统性的失语症 检查将体育锻炼训练与传统语言相结合的添加和增强的效果 治疗。创新的结果措施不仅包括语言和认知措施，还包括措施 运动技能以及心理和心理社会成果，这些结果将评估体育锻炼的益处。 该研究的另一个尖端方面是包括先进的生理适应性措施和 血流和脑血管反应性的神经影像学指标作为结果措施，以提供更深层次 了解中风幸存者中运动介导的行为和神经效应。 我们将招募110个人失语症，以评估锻炼对行为的多方面影响 以及孤立的身体结局，并结合传统的语音语言疗法。首先， 体育锻炼对语言，认知，运动以及情感和心理健康的好处 失语症的个人将被建立。特别重要的是，将加强对 运动可以增强现有语言疗法的影响。其次，确定运动引起的 身体适应性的变化与语言的变化有关，认知措施将为您提供洞察力 成功锻炼干预措施的关键要素。第三，评估运动引起的神经血管 与新型血液供应神经成像工具一起测量的与行为改善有关的变化将 促进我们对观察到的认知益处的大脑机制的了解。最后，已验证 该项目导致的体育锻炼干预将为寻求帮助的临床医生提供新工具 失语症的个人，要么是一项独立计划，以增强身体健康，认知和福祉， 或作为标准语言疗法的辅助疗法。最终，这项工作可能会大大改变我们的 考虑可以通过非中风和失语症受益的辅助失语症疗法 在这种情况下 从一般健康到语言再到社会参与的功能水平。