Molecular Dissection of Mitochondria-Organelle Interactions

线粒体-细胞器相互作用的分子解剖

基本信息

批准号：
10851148
负责人：
Yasemin S Sancak
金额：
$ 9.57万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10851148
关键词：
Administrative Supplement Affect Bachelor&apos s Degree Biochemical Biochemical Reaction Biological Assay Biology Biotin Biotinylation Calcium Signaling Cell Death Cell membrane Cell model Cells Clinical Communication Confocal Microscopy Continuing Education Coupled Critical Thinking Data Development Disease Disease model Dissection Doctor of Philosophy Environment Funding Genetic Goals Golgi Apparatus Growth Homeostasis Image Image Analysis Imaging Techniques Impairment Inherited Ions Label Latino Ligase Lipids Lysosomes Mentors Metabolic Diseases Metabolism Methods Mitochondria Mitochondrial Diseases Molecular Natural Immunity Neurodegenerative Disorders Non-Insulin-Dependent Diabetes Mellitus Organelles Parkinson Disease Pathogenesis Patient advocacy Play Population Preparation Regulation Research Reticulum Role Sampling Science Scientist Signal Transduction Site Surface Testing Therapeutic Toxic Environmental Substances Training Underrepresented Minority United States National Institutes of Health Validation Work career design disability experience extracellular fitness high resolution imaging innovation interest mitochondrial dysfunction novel parent grant pharmacologic programs proteostasis quantitative imaging responsible research conduct skills therapeutic target

Administrative Supplement Affect Bachelor&apos s Degree Biochemical Biochemical Reaction Biological Assay Biology Biotin Biotinylation Calcium Signaling Cell Death Cell membrane Cell model Cells Clinical Communication Confocal Microscopy Continuing Education Coupled Critical Thinking Data Development Disease Disease model Dissection Doctor of Philosophy Environment Funding Genetic Goals Golgi Apparatus Growth Homeostasis Image Image Analysis Imaging Techniques Impairment Inherited Ions Label Latino Ligase Lipids Lysosomes Mentors Metabolic Diseases Metabolism Methods Mitochondria Mitochondrial Diseases Molecular Natural Immunity Neurodegenerative Disorders Non-Insulin-Dependent Diabetes Mellitus Organelles Parkinson Disease Pathogenesis Patient advocacy Play Population Preparation Regulation Research Reticulum Role Sampling Science Scientist Signal Transduction Site Surface Testing Therapeutic Toxic Environmental Substances Training Underrepresented Minority United States National Institutes of Health Validation Work career design disability experience extracellular fitness high resolution imaging innovation interest mitochondrial dysfunction novel parent grant pharmacologic programs proteostasis quantitative imaging responsible research conduct skills therapeutic target

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项目摘要

ABSTRACT This is a request for an administrative supplement for NIH DP2ES032761 titled “Molecular Dissection of Mitochondria-Organelle Interactions”. This project aims to identify the signals that originate from other organelles and regulate mitochondria in healthy cells and target them in mitochondrial dysfunction for therapeutic gain, using an innovative mitochondrial labelling and isolation strategy coupled to imaging. In this supplement, we propose to determine how of mitochondria-organelle interactions change in cellular models of mitochondrial diseases, using high resolution imaging techniques and biochemical methods. This administrative supplement will provide an outstanding co-mentored training experience of an underrepresented minority baccalaureate degree holder, Francisco Miralles, whose career goal is to continue his education in an MD/Ph.D program.

抽象的这是对NIH DP2ES032761的行政补充的要求线粒体 - 轨道相互作用”。该项目旨在确定源自其他的信号细胞器和调节健康细胞中的线粒体，并在线粒体功能障碍中靶向它们使用创新的线粒体标记和隔离策略结合了想象的治疗增益。在这个补充，我们建议确定线粒体 - 轨道相互作用在细胞模型中的变化线粒体疾病，使用高分辨率成像技术和生化方法。这行政补充剂将提供出色的共同培训经验少数学士学位持有人弗朗西斯科·米拉勒斯（Francisco Miralles）的职业目标是继续他的教育 MD/PH.D程序。