Mobile Health Technology for Personalized Tobacco Cessation Support in Laos

移动健康技术在老挝提供个性化戒烟支持

• 批准号: 10886151
• 负责人: Thanh C. Bui
• 金额: $ 23.31万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10886151
• 关键词: Abstinence; Address; Adoption; Adult; Applications Grants; Behavior Therapy; Biochemical; Cambodia; Cambodian; Cellular Phone; Cigarette; Clinics and Hospitals; Collaborations; Communication; Confidence Intervals; Control Groups; Country; Data; Developed Countries; Development; Ecological momentary assessment; Educational workshop; Enrollment; Evaluation; Future; Goals; Health; Health Promotion; Health Technology; Hospitals; Image; Income; Influentials; Inservice Training; Institution; Intervention; Language; Laos; Manuscripts; Mobile Health Application; Morbidity - disease rate; Outcome; Participant; Patient Self-Report; Patients; Persons; Phase; Pilot Projects; Preparation; Prevalence; Proliferating; Province; Public Health; Publishing; Randomized; Randomized, Controlled Trials; Relative Risks; Reporting; Research; Research Methodology; Research Personnel; Smoker; Smoking Cessation Intervention; Surveys; Technology; Tobacco; Tobacco Use Cessation; Tobacco smoke; Tobacco use; Training; Wireless Technology; Woman; World Health Organization; Writing; brief advice; cost effective; efficacy evaluation; follow-up; global health; health care service; insight; knowledge base; low and middle-income countries; mHealth; men; mobile computing; mortality; nicotine replacement; novel; personalized intervention; personalized medicine; pilot test; programs; randomized trial; recruit; secondary outcome; self help; sex; smoking cessation; smoking prevalence; social culture; standard care; support network; text messaging intervention; tobacco cessation intervention; tobacco control; tool; treatment group; treatment program

PROJECT SUMMARY: Tobacco use remains the leading cause of preventable morbidity and mortality worldwide. Although tobacco use has declined in developed nations in recent decades, smoking prevalence remains strikingly high in many low- and middle-income countries (LMICs). In Lao People's Democratic Republic (Lao PDR), 51% of adult men and 7% of adult women smoke tobacco. The development and evaluation of sustainable tobacco cessation interventions suitable for widespread adoption in nations such as Lao PDR are pressing public health needs. To address this need, we propose a project that adapts our theoretically and empirically based mobile health (mHealth) technology to help people quit smoking cigarettes in Lao PDR. This mHealth approach includes a fully automated, interactive, personalized, smartphone- delivered intervention for behavioral treatment, delivered through our Insight™ platform. mHealth interventions are proliferating in developed countries, but efforts to utilize similar approaches in Lao PDR are extremely limited. The World Health Organization acknowledges that using mHealth for health promotion is cost-effective, scalable, and sustainable, including for the least-developed countries. Additionally, text-messaging interventions for smoking cessation have been shown to be effective, cost-effective, and affordable for tobacco control globally. We have already developed the mHealth platform and intervention approach proposed for this study and pilot tested this technology with a group of Cambodian smokers. Preliminary results demonstrated that our mHealth technology is efficacious, highly feasible, appropriate, and potentially scalable for LMIC settings. This proposed project for Lao PDR includes 2 main phases. In the R21 Phase, we will use formative research methods to adapt our intervention content to the sociocultural context, language, and communication styles of Laotians. In the subsequent R33 Phase, we will conduct a randomized controlled trial (RCT) to evaluate the efficacy of our mHealth intervention and technology. Adult smokers of both sexes will be recruited through 2 large hospitals: Setthathirath Hospital in Vientiane and Champasak Hospital in Champasak Province. Participants (n=500) will be randomized to 1 of 2 treatment groups: Standard Care (SC; n=250) or Automated Treatment (AT; n=250). SC consists of brief advice to quit smoking delivered by research staff, self- help written materials, and a 2-week supply of NRT (transdermal patches). AT consists of all SC components plus a fully automated smartphone-based treatment program that involves interactive and personalized proactive messages, images, or videos. The primary health outcome of the trial is biochemically confirmed self- reported 7-day point prevalence abstinence 12 months post study enrollment. The project also aims to advance mHealth research capacity in Lao PDR and sustain the US-Lao PDR research network. The project has the potential to transform healthcare services for tobacco cessation treatment throughout the country and, ultimately, to significantly reduce tobacco-induced morbidity and mortality.

项目摘要：烟草使用仍然是可预防发病率和死亡率的主要原因 全球。尽管烟草的使用在发达国家近几十年以来，吸烟率有所下降 在许多低收入和中等收入国家（LMIC）中，仍然很高。在老年人民的民主中 共和国（Lao PDR），51％的成年男性和7％的成年女性吸烟。发展和 评估可持续烟草戒烟干预措施，适合于诸如 老挝PDR迫使公共卫生需求。为了满足这一需求，我们提出了一个适应我们的项目 理论和基于经验的移动健康（MHealth）技术，以帮助人们戒烟香烟 在老挝Pdr。这种MHealth方法包括一种全自动，互动，个性化的智能手机 - 通过我们的Insight™平台交付的行为处理干预措施。 MHealth干预措施 在发达国家正在激增，但是在老挝PDR中使用类似方法的努力极为 有限的。世界卫生组织承认，使用MHealth进行健康促进具有成本效益， 可扩展且可持续的，包括最不发达国家的国家。另外，文字发音 戒烟的干预措施已被证明是有效的，具有成本效益且负担得起的烟草 全球控制。我们已经开发了为此提出的MHealth平台和干预方法 研究和飞行员用一群柬埔寨吸烟者测试了这项技术。展示了初步结果 我们的MHealth技术是有效的，高度可行的，适当的，并且可能可扩展到LMIC 设置。 LAO PDR的拟议项目包括2个主要阶段。在R21阶段，我们将使用形成性 研究方法将我们的干预内容适应社会文化背景，语言和交流 老挝人的风格。在随后的R33阶段，我们将进行一项随机对照试验（RCT） 评估我们的MHealth干预和技术的效率。两性的成年吸烟者将被招募 通过2家大型医院：Vientiane的Santhathirath医院和Champasak的Champasak医院 省。参与者（n = 500）将随机分为2个治疗组中的1个：标准护理（SC; n = 250）或 自动处理（; n = 250）。 SC包括简短的建议，以戒除研究人员提供的吸烟，自我 帮助书面材料和2周的NRT供应（透皮补丁）。由所有SC组成部分组成 加上一个完全自动化的基于智能手机的治疗计划，涉及互动和个性化 主动消息，图像或视频。该试验的主要健康结果是生化证实的自我 研究入学后报道了7天的戒酒12个月。该项目还旨在 提高LAO PDR的MHealth研究能力，并维持US-LAO PDR研究网络。项目 有可能改变全国各地戒烟治疗的医疗服务，并 最终，大大降低了烟草引起的发病率和死亡率。