MIND-the-SKIN Project: Multi-functional Innovative Digital Toolkit for the Skin Diseases in LMICs and Beyond

MIND-the-SKIN 项目：针对中低收入国家及其他地区皮肤病的多功能创新数字工具包

• 批准号: 10880476
• 负责人: Rie Yotsu
• 金额: $ 27.1万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-25 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10880476
• 关键词: Address; Affect; Africa; Africa South of the Sahara; African; Algorithms; Area; Artificial Intelligence; Buruli Ulcer; Caring; Case Management; Cellular Phone; Child; Clinical; Clinical Skills; Clinical effectiveness; Collaborations; Collection; Communities; Country; Darkness; Data; Data Collection; Decision Support Systems; Deformity; Dermatologic; Dermatologist; Dermatology; Detection; Development; Diagnosis; Diagnostic; Disease Outcome; Early Diagnosis; Early treatment; Economics; Education; Epidemiologic Monitoring; Equipment; Family; Filarial Elephantiases; Future; Goals; Health; Health Personnel; Healthcare; Image; Impact evaluation; Individual; Infectious Skin Diseases; Intervention; Interview; Ivory Coast; Japan; Left; Leprosy; Lesion; Measures; Medical; Methodology; Outcome; Patients; Performance; Phase; Photography; Prevalence; Process; Psyche structure; Recording of previous events; Records; Remote Consultation; Research; Research Personnel; Rural; Series; Services; Site; Skin; Skin Manifestations; Specialist; Standardization; Surveys; System; Tablets; Technology; Telemedicine; Training; Treatment outcome; Tropical Medicine; Underserved Population; Universities; Validation; Visual; Work; World Health Organization; Yaws; clinical decision support; data sharing; design; digital; digital health; disability; disorder control; effectiveness study; experience; follow-up; health training; improved; individual patient; innovation; intelligent diagnosis; low and middle-income countries; mHealth; meetings; member; neglected tropical diseases; novel; physically handicapped; pilot trial; portability; prototype; sharing platform; skills; skin color; skin disorder; skin lesion; social; support tools; teledermatology; tool; two-arm study; usability; wound; wound care; wound healing; wound treatment

MIND-the-SKIN Project: Multi-functional Innovative Digital Toolkit for the Skin Diseases in LMICs and Beyond The prevalence of skin diseases is extremely high in sub-Saharan Africa, particularly in children. If left untreated, some have debilitating lifelong physical disabilities and deformities, as well as social and mental effects. Among them are skin infections which are listed as members of the Neglected Tropical Diseases (NTDs) by the World Health Organization and targeted for disease control globally. Many of the NTDs, including leprosy, Buruli ulcers, yaws, and lymphatic filariasis, are co-endemic in West Africa. Early detection and treatment is currently the most effective measures for their disease control. However, this is hampered by a paucity of skilled healthcare workers in the remote areas of the LMICs where they prevail. On the other hand, diagnosis of these conditions can be done with patient history and simple skin examination, without undergoing invasive examinations requiring special skills and equipment. This is very well suited to field settings in LMICs. With a targeted training, technology-assisted decision-support system and a telemedicine network, local healthcare workers could be leveraged to enhance the diagnosis and management of the skin conditions. This project proposes to do so through development and validation of an mHealth tool for skin diseases in LMICs: the ‘eSkinHealth’ application. It is a portable smartphone or tablet application that could provide: a) direct diagnostic and management assistance to healthcare workers in remote setting, and through teledermatology, b) storage of longitudinal patients records for improved follow-up, and c) organization of clinical and image data of the skin. There is a general lack of good clinical photos of skin diseases on dark skin, and collection of photos made through this project could be further used for development of photo guides for wide use and future studies on dermatology of skin of color. The purpose of the proposed research is to complete development and optimization of eSkinHealth and carry out its effectiveness studies on the field. The R21 phase of the work will assess the feasibility, usability, and acceptability of the prototype, validation of a novel built-in wound scoring system, and standardization and optimization of dermatologic photography on dark skin. The R33 phase will evaluate the performance of the app on outcomes of surveillance and management of NTDs and further optimization of photo analysis of skin lesions on dark skin using the image optimization technology. The research will be carried out in a western-African country of Côte d’Ivoire. It will build on our previous work in surveillance of NTDs in rural Côte d’Ivoire and trainings to local healthcare workers, as well as our expertise in mHealth. It will leverage our multi-year collaboration with investigators from Côte d’Ivoire, application developers in Japan, and tropical medicine expertise from Tulane University. If successful, eSkinHealth will be instrumental in overcoming the current gaps and weaknesses in dermatological services in LMICs providing a breakthrough to management of skin diseases in this underserved populations, as well as contributing to the dermatology of skin of color worldwide, envisioning Skin Health for All.

MIND-the-SKIN 项目：针对中低收入国家和地区皮肤病的多功能创新数字工具包 超过 撒哈拉以南非洲地区皮肤病的患病率极高，尤其是儿童。 如果不加以治疗，有些人会终生造成身体残疾和畸形，以及社会和精神方面的残疾 其中包括被列为被忽视的热带疾病的皮肤感染。 (NTD) 被世界卫生组织列为全球疾病控制目标。 包括麻风病、布鲁里溃疡、雅司病和淋巴丝虫病，是西非的共同流行病。 治疗是目前控制其疾病最有效的措施，然而，这受到了阻碍。 另一方面，中低收入国家的偏远地区缺乏熟练的医疗工作者。 这些病症的诊断可以通过患者病史和简单的皮肤检查来完成，无需进行 需要特殊技能和设备的侵入性检查非常适合中低收入国家的现场设置。 凭借有针对性的培训、技术辅助决策支持系统和远程医疗网络，当地 可以利用医护人员来加强皮肤状况的诊断和管理。 项目建议通过开发和验证针对中低收入国家皮肤病的移动医疗工具来实现这一目标： “eSkinHealth”应用程序是一款便携式智能手机或平板电脑应用程序，可以提供：a）直接。 通过远程皮肤病学，为远程环境中的医护人员提供诊断和管理援助， b) 存储纵向患者记录以改善随访，以及 c) 组织临床和图像数据 普遍缺乏深色皮肤皮肤病的良好临床照片和收集。 通过该项目制作的照片可以进一步用于开发照片指南以供广泛使用和 彩色皮肤皮肤病学的未来研究 拟议研究的目的是完成。 eSkinHealth 的开发和优化并在该领域开展其有效性研究。 该工作阶段将评估原型的可行性、可用性和可接受性、新颖性的验证 内置伤口评分系统，以及深色皮肤皮肤病摄影的标准化和优化。 R33 阶段将评估应用程序在监视和管理结果方面的性能 NTD 和使用图像优化对深色皮肤皮肤病变的照片分析进行进一步优化 该研究将在西非国家科特迪瓦进行。 此前在科特迪瓦农村地区开展的被忽视热带病监测工作以及对当地医护人员的培训，以及 它将利用我们与科特迪瓦研究人员的多年合作， 日本的应用程序开发人员和杜兰大学的热带医学专业知识如果成功， eSkinHealth 将有助于克服当前皮肤科服务的差距和弱点 中低收入国家为这一服务不足的人群的皮肤病管理提供了突破，以及 为全球有色皮肤的皮肤病学做出贡献，展望所有人的皮肤健康。