Maternal Diabetes during Pregnancy and Neurodevelopment in the Offspring

妊娠期母亲糖尿病与后代神经发育

• 批准号: 8890396
• 负责人: Jasveer Virk
• 金额: $ 14.6万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-11 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8890396
• 关键词: Acceleration; Affect; Antioxidants; Area; Asses; Attention; Attention deficit hyperactivity disorder; Autistic Disorder; Autoimmunity; Behavior; Behavioral; Biological; Birth; Blood Glucose; Brain; Child; Chronic; Clinical; Cognition; Cognitive deficits; Cohort Studies; Collaborations; Data; Data Analyses; Denmark; Development; Diabetes Mellitus; Diagnosis; Disease; Environment; Environmental and Occupational Exposure; Epidemiology; Exposure to; Female of child bearing age; Fertility; Fetal Tissues; Free Radicals; Genetic; Gestational Diabetes; Glucose; Hospitals; Household; Hyperglycemia; Hyperinsulinism; Hypoxia; Impairment; Inflammation; Inflammatory; Insulin Signaling Pathway; Insulin-Dependent Diabetes Mellitus; Interferons; Interleukin-1; Interleukin-2; Interleukin-6; Investigation; Language; Lead; Link; Lipids; Measures; Medical; Memory; Mentored Research Scientist Development Award; Mentors; Military Personnel; Mothers; Motor Skills; Neurodevelopmental Impairment; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Outpatients; Performance; Population; Positioning Attribute; Pregnancy; Pregnancy in Diabetics; Pregnant Women; Process; Production; Reaction; Recording of previous events; Registries; Research; Research Support; Resources; Risk; Series; Source; System; Testing; Training; Universities; Variant; age group; autism spectrum disorder; base; biobank; cohort; cytokine; diabetes control; diabetes risk; experience; fetal; fetal programming; follow-up; glucose metabolism; inattention; insulin secretion; lipid metabolism; maternal diabetes; motor impairment; neurobehavioral; neurodevelopment; offspring; oxidation; prenatal exposure; prenatal risk factor; professor; public health relevance; repository; trait; trend; white matter

 DESCRIPTION (provided by applicant): This proposal builds on eight years of the candidate's previously conducted research on adverse prenatal exposures using the Danish Civil Registration System and Danish medical registers, and outcomes in the offspring. Through existing collaborations with Danish colleagues, the candidate has gained access and extensive experience with these unique, large-scale, nationwide registries. She now proposes to apply these resources to conduct the largest and most comprehensive study to date to examine the relationship between maternal diabetes and an array of neurodevelopmental outcomes that include markers of cognition, behavior, attention and motor skills. This application proposes a series of nationwide population cohort studies that will utilize the Danish Civil Registration System and Danish medical registers. It has the unique advantage of also incorporating a very large previously established cohort that is nested in the total population of Denmark and contains extensive maternal demographic histories in addition to household, environmental, and occupational exposures; this will inform the study on co-adversities in the fetal environment. Furthermore, another unique advantage of this study is the ability to asses an array of neurodevelopmental outcomes in the same population cohort, minimizing many sources of bias, and aiding the interpretation of these findings. This Mentored Research Scientist Development Award will be pursued within the context of a strong ongoing collaborative relationship between the UCLA Department of Epidemiology, Aarhus University and the UCLA Center for Autism Research and Treatment (CART). This application will provide training in neurobehavioral genetics so that the candidate can build a skillset compatible with analyzing data from large repositories available for research in the Nordic biobanks, and obtain depth in understanding of fetal programming of neurodevelopmental outcomes. Drs. Beate Ritz and Jorn Olsen have agreed to mentor the candidate through the K99 process. Dr. Dan Geschwind will oversee the candidate's training in neurobehavioral genetics, Dr. Diana Schendel will provide scientific and technical guidance on the project and Dr. Tania Esakoff will inform the project with her clinical experience in managing diabetes in pregnancy. The contents of this application provide a strategy to position the candidate such that she can launch successfully into a tenured professor track position, and gain the necessary experience to move towards independence and pursue R01 proposals.

 描述（由申请人提供）：该提案以候选人之前使用丹麦民事登记系统和丹麦医疗登记册进行的不良产前暴露研究以及通过与丹麦同事的现有合作对后代的结果进行了八年的研究为基础。通过这些独特的、大规模的、全国性的登记获得了丰富的经验，她现在建议利用这些资源进行迄今为止规模最大、最全面的研究，以检查孕产妇糖尿病与一系列神经发育结果之间的关系。包括认知、行为、注意力和运动技能的标记。该应用程序提出了一系列全国人口队列研究，该研究将利用丹麦民事登记系统和丹麦医疗登记册，它的独特优势是还纳入了先前建立的大量队列。嵌套在丹麦总人口中，除了家庭、环境和职业暴露之外，还包含广泛的母亲人口统计历史；这将为胎儿环境中的共同逆境的研究提供信息。此外，这项研究的另一个独特优势是能力。评估一系列神经发育该研究科学家发展奖将在加州大学洛杉矶分校流行病学系、奥胡斯大学和加州大学洛杉矶分校之间持续不断的合作关系的背景下进行。自闭症研究和治疗中心 (CART) 该应用程序将提供神经行为遗传学方面的培训，以便候选人能够建立与分析可用于北欧研究的大型存储库中的数据兼容的技能。 Beate Ritz 博士和 Jorn Olsen 博士同意通过 K99 流程指导候选人，Dan Geschwind 博士将监督候选人的神经行为遗传学培训。为该项目提供科学和技术指导，Tania Esakoff 博士将向该项目提供她在管理妊娠期糖尿病方面的临床经验。该申请的内容提供了一个策略来定位候选人，以便她能够。成功晋升终身教授职位，并获得走向独立和追求 R01 提案所需的经验。