Reducing blood pressure in mid-life adult binge drinkers: the role of microvascular function and sympathetic activity

降低中年成人酗酒者的血压：微血管功能和交感神经活动的作用

基本信息

批准号：
10834571
负责人：
Chueh-Lung Hwang
金额：
$ 4.36万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-10 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10834571
关键词：
Acceleration Address Adult Alcohol consumption Alcohols Aorta Area Arteries Blood Blood Pressure Blood Vessels Blood Volume Blood flow Brain Brain Injuries Brothers Buffers Cardiovascular system Career Mobility Carotid Arteries Chronic Communication Dementia Development Disease Doppler Ultrasound Dryness Elasticity Enrollment Event Female Fostering Future Goals Grant Health Heart Hypertension Impaired cognition Kinesiology Knowledge Knowledge acquisition Laboratories Leadership Left ventricular structure Limb structure Mentors Mentorship Minority Groups Mission Myocardial Contraction National Institute on Alcohol Abuse and Alcoholism Nerve Organ Parents Patient Self-Report Pattern Phase Physiologic pulse Physiology Play Postdoctoral Fellow Property Questionnaires Research Research Personnel Research Priority Research Project Grants Research Support Research Training Risk Risk Factors Role Scientist Spottings Training Travel Underrepresented Minority Vascular System alcohol research arterial stiffness binge drinker binge drinking blood pressure reduction blood pressure regulation career career development career preparation doctoral student heart function hemodynamics member middle age novel organ injury parent project phosphatidylethanol prevent programs senior faculty skills theories tonometry wasting

项目摘要

Project Summary/Abstract This supplement supports the diversity candidate, a second-year doctoral student in Kinesiology, and fosters his research career development toward becoming a scientist in the field of vascular physiology and alcohol- related health research. The research training and professional development activities, under this supplement, are facilitated by a strategic mentoring plan and incorporated into the parent R00 project. The parent R00 grant has been targeting microvascular function and sympathetic nerve activity to understand the mechanisms underlying alcohol-attributable contribution to elevated systolic blood pressure and prevent the negative health consequences in mid-life adults. Nevertheless, binge drinking, the most common pattern of excessive alcohol use, can also cause elevated systolic blood pressure through increased arterial stiffness which, in theory, results in hemodynamic changes, such as enhance aortic wave reflection and carotid artery wave intensity. These hemodynamic changes play a significant role not only in blood pressure regulation but also in the function of the heart and the brain. Understanding alcohol-induced arterial stiffening and the related hemodynamic changes is significant because it helps predict the subsequent progression of organ injury by alcohol. The diversity candidate will complete the proposed research to address the overarching hypothesis – “chronic binge drinking contributes to the changes in aortic and carotid hemodynamic in mid-life adults due to arterial stiffness.” During the supplement period, the diversity candidate will receive mentored training with the PI of the parent project to enhance his knowledge and skills in alcohol use assessments and the harmful effect of binge drinking on arterial stiffness and hemodynamics. He will also receive mentored professional development to enhance his communication, leadership, and management skills, as well as professionalism. The PI is a female early-stage investigator and is committed to career and professional development for her trainees. The proposed training plan under this supplement will be facilitated by a senior faculty member, Dr. R. Matthew Brothers. This supplement will not only help facilitate the candidate’s progress toward his next stage of career, but also help enrich the PI’s reach program with the involvement of trainees from diverse backgrounds and establish her laboratory at the early stage of her career. In addition, increasing the number of scientists from non-traditional backgrounds (i.e., kinesiology) in the field of alcohol research will enhance the diversity of alcohol research, ultimately accelerating the pace of research in alcohol-related health. Therefore, this diversity supplement is consistent with the overarching mission and research priority areas of NIAAA.

项目摘要/摘要这种补充支持多样性候选人，二年级的运动机能学博士生，并促进他的研究职业发展旨在成为血管生理学和酒精领域的科学家 - 相关的健康研究。研究培训和专业发展活动，在此补充下，由战略心理计划制定，并将其纳入父r00项目中。父r00赠款一直在靶向微血管功能和交感神经活动以了解机制基本的酒精 - 基因贡献对收缩压升高并防止健康状况负面影响中年成年人的后果。然而，Bbinge喝酒，是多余酒精的最常见模式使用，还可以通过增加动脉刚度引起收缩压升高，从理论上讲，导致血液动力学变化，例如增强的波形反射和颈动脉波强度。这些血液动力学变化不仅在血压调节中起着重要作用，而且在心脏和大脑的功能。了解酒精引起的伪影僵硬和相关血流动力学变化很大，因为它有助于预测器官损伤随后通过酒精。多样性候选人将完成拟议的研究，以解决总体假设 - “慢性暴饮暴食有助于中期成年人主动脉和颈动脉血流动力学的变化在补充期间，多样性候选人将接受培训父母项目的PI，以增强他在酒精使用评估方面的知识和技能和有害效果在动脉僵硬和血液动力学上的暴饮暴食。他还将获得指导的专业人士发展以增强他的沟通，领导和管理技能以及专业精神。 PI是一名女性早期调查员，致力于她的职业和专业发展学员。根据该补充的拟议培训计划将由高级教师博士准备。 R. Matthew兄弟。这种补充不仅将有助于促进候选人的下一个进步职业阶段，但也有助于通过潜水员的学员参与来丰富PI的覆盖范围计划背景并在职业生涯的早期建立她的实验室。另外，增加了来自非传统背景的科学家（即酒精研究领域的运动机能学）将增强酒精研究的多样性，最终增加了与酒精有关的健康研究的速度。所以，这种多样性补充与NIAAA的总体使命和研究优先领域一致。