Blast Wave Effects: Hearing, Memory, Therapy

爆炸波效应：听力、记忆、治疗

基本信息

批准号：
8675221
负责人：
RICHARD J SALVI
金额：
$ 40.22万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8675221
关键词：
Action Potentials Address Adult Affect Antioxidants Apoptosis Apoptotic Blast Cell Brain Brain region Cell Death Cells Cochlea Cochlear Hearing Loss Data Dementia Dose Employee Strikes Epidemiologic Studies Explosion Exposure to Goals Hair Cells Healthcare Hearing Helmet Hippocampus (Brain)Injury Intervention Studies Labyrinth Life Measures Memory Memory impairment Methionine Military Personnel Necrosis Neuraxis Newborn Infant Noise Noise-Induced Hearing Loss Pathology Performance Pharmaceutical Preparations Pharmacotherapy Play Prevention Property Rattus Reporting Risk Risk Factors Role Services Short-Term Memory Testing Therapeutic Intervention Therapeutic Studies Tracer Trauma Traumatic Brain Injury Treatment Efficacy United States Department of Veterans Affairs Veterans auditory pathway base clinically relevant disability hearing impairment insight interest meetings middle ear neurogenesis neurotoxicity novel otoacoustic emission pressure prevent research study response sound stem cell niche way finding

项目摘要

DESCRIPTION (provided by applicant): Blast wave explosions are a major cause of hearing loss among military personnel, but blasts can also induce traumatic brain injury and impair memory. In preliminary experiments, we have shown that exposure to blast waves and continuous noise not only damaged the inner ear, but caused cell death in the hippocampus, suppressed neurogenesis and impaired memory function. The goals of this project are to: (1) Assess the amount of functional hearing impairment and cochlear damage (necrosis and apoptosis) that results from blast wave vs. continuous noise exposures. (2) Determine the extent to which D-methionine, an anti-antioxidant and apoptotic agent, can protect against blast wave induced hearing impairment and cochlear pathology. (3) Determine the extent to which blast wave exposure disrupts memory function and induces cell death and suppresses neurogenesis in the hippocampus. (4) Determine if D-methionine can protect against blast wave induced memory impairments, prevent hippocampal cell death and restore hippocampal neurogenesis. These studies will provide new mechanistic insights on the role of necrosis and apoptosis in blast and noise induced injury to the inner ear and hippocampus and whether antioxidant, anti-apoptotic drug therapy can prevent or ameliorate blast wave injury to the inner ear and hippocampus.

描述（由申请人提供）：冲击波爆炸是军事人员听力损失的主要原因，但爆炸也会引起创伤性脑损伤并损害记忆。在初步实验中，我们已经表明，暴露于冲击波和连续噪音中不仅会损害内耳，还会导致海马体细胞死亡，抑制神经发生并损害记忆功能。该项目的目标是： (1) 评估冲击波与连续噪声暴露导致的功能性听力障碍和耳蜗损伤（坏死和细胞凋亡）的程度。 (2) 确定 D-蛋氨酸（一种抗氧化剂和细胞凋亡剂）在多大程度上可以预防冲击波引起的听力损伤和耳蜗病变。 (3) 确定冲击波暴露破坏记忆功能、诱导细胞死亡和抑制海马神经发生的程度。 (4) 确定D-蛋氨酸是否可以预防冲击波引起的记忆障碍、防止海马细胞死亡并恢复海马神经发生。这些研究将为坏死和细胞凋亡在冲击波和噪声引起的内耳和海马损伤中的作用以及抗氧化剂、抗细胞凋亡药物治疗是否可以预防或改善冲击波对内耳和海马损伤的作用提供新的机制见解。