Molecular Transducers of Physical Activity Consortium (MoTrPAC): Pediatric Clinical Center

体力活动分子传感器联盟 (MoTrPAC)：儿科临床中心

• 批准号: 10841339
• 负责人: DAN M COOPER
• 金额: $ 141万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-06 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10841339
• 关键词: 17 year old; 18 year old; Acceleration; Acute; Adolescent; Adult; Age; Age Years; Ancillary Study; Animals; Award; Bioinformatics; Biological Process; Blood; COVID-19 pandemic; Charge; Chemicals; Child; Childhood; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communication; Communities; Data; Development; Disease; Disease Outcome; Educational Intervention; Enrollment; Ensure; Exercise; Exercise Test; Frequencies; Funding; Gender; Goals; Health; Health Benefit; Heterogeneity; Human; Individual; Institution; Institutional Review Boards; Intervention; Longevity; Manuals; Manuscripts; Maps; Measurement; Minority Groups; Molecular; Multi-site clinical study; Observational Study; Participant; Pathway interactions; Phase; Phenotype; Physical activity; Physiological; Procedures; Protocols documentation; Public Health; Race; Randomized; Randomized, Controlled Trials; Recruitment Activity; Research; Research Personnel; Resistance; Resources; Schedule; Site; Suspensions; Time; Tissues; Training; Training Programs; Transducers; United States National Institutes of Health; Visit; Youth; age group; clinical center; cohort; design; endurance exercise; ethnic minority; exercise training; falls; follow-up; gender equality; improved; innovation; insight; multiple omics; novel; operation; pandemic disease; phenotypic data; pre-clinical; public database; quality assurance; racial minority; recruit; resistance exercise; response; sedentary; sex; working group; 17 year old; 18 year old; Acceleration; Acute; Adolescent; Adult; Age; Age Years; Ancillary Study; Animals; Award; Bioinformatics; Biological Process; Blood; COVID-19 pandemic; Charge; Chemicals; Child; Childhood; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communication; Communities; Data; Development; Disease; Disease Outcome; Educational Intervention; Enrollment; Ensure; Exercise; Exercise Test; Frequencies; Funding; Gender; Goals; Health; Health Benefit; Heterogeneity; Human; Individual; Institution; Institutional Review Boards; Intervention; Longevity; Manuals; Manuscripts; Maps; Measurement; Minority Groups; Molecular; Multi-site clinical study; Observational Study; Participant; Pathway interactions; Phase; Phenotype; Physical activity; Physiological; Procedures; Protocols documentation; Public Health; Race; Randomized; Randomized, Controlled Trials; Recruitment Activity; Research; Research Personnel; Resistance; Resources; Schedule; Site; Suspensions; Time; Tissues; Training; Training Programs; Transducers; United States National Institutes of Health; Visit; Youth; age group; clinical center; cohort; design; endurance exercise; ethnic minority; exercise training; falls; follow-up; gender equality; improved; innovation; insight; multiple omics; novel; operation; pandemic disease; phenotypic data; pre-clinical; public database; quality assurance; racial minority; recruit; resistance exercise; response; sedentary; sex; working group

PROJECT SUMMARY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) that are randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric clinical centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led to the NIH Common Fund to release the current NOFO (RFA-RM- 23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.

项目摘要 体育活动联盟（MOTRPAC）的分子换能器旨在发现和表征 锻炼人类影响的基础的分子传感器的范围。 Motrpac发射 2016年设有六个成人临床中心和一个儿科中心，他们合作生成了大量手册 指导涉及临床操作各个方面的研究方案（I阶段）的操作。第二阶段 始于2019年秋天，所有人类临床中心在初次招募方面都取得了出色的进步 协议的目标和实施。 NIH提出的最初目标是招募270名儿童（10-17 年龄）和1980年久坐的成年人（年龄在18岁或更高的年龄）中，它们被随机进行耐力训练 （170名青年，840名成年人），抵抗训练（840名成人）或非运动控制（50名青年，300名成人）。一个 额外的高度活跃耐力（50名青年，150名成人）和受过训练的人（150名成人） 用作比较者，不参加Motrpac锻炼培训计划。招聘和 招生方法是性别平衡的，并且参与者跨越各个年龄段（10-17、18-39、40-59 和> 60岁的年龄段）和不同的种族。由于199大流行，Motrpac活性是 暂停一年多（从2020年3月开始），直到2022年，仍有持续的限制。 大流行，成人和小儿招募活动遇到的许多挑战 临床中心已加速到预计成功实现目标入学人数的速度 到新奖励期结束时。这导致NIH共同基金释放当前的NOFO（RFA-RM-- 23-010）为MOTRPAC提供资金，以完成临床研究的招聘和随访，包括 久坐的成年人和儿童的完成机械的随机对照试验以及观察性研究 高度活跃的成年人和儿童。这将丰富参与者的队列，这对于了解锻炼至关重要 跨年龄，性别和少数群体的适应和异质性。总共，此扩展名将允许 MOTRPAC完成原始设想的预期目标，并将提供更完整的公众 锻炼健康益处的数据库，并提供有关体育活动如何减轻疾病的洞察力。