New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

• 批准号: 10846315
• 负责人: ANEESH B SINGHAL
• 金额: $ 10.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10846315
• 关键词: Achievement; Adult; Area; Blood Vessels; Boston; Caring; Child; Childhood stroke; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Discipline; Emergency Medicine; Enrollment; Funding; General Hospitals; Geography; Health; Hospitals; Infrastructure; International; Investigation; Israel; Leadership; Massachusetts; Medical center; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurologic; Neurology; New England; New Hampshire; Patient Care; Pediatric Hospitals; Performance; Phase; Positioning Attribute; Principal Investigator; Records; Rehabilitation therapy; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Seasons; Site; Stroke; StrokeNet clinical trials; StrokeNet trials; Talents; Translational Research; United States National Institutes of Health; Universities; Vermont; Vision; Woman; clinical translation; innovation; member; metropolitan; neuroimaging; neurosurgery; patient population; pre-clinical; programs; recruit; skills; stroke neurology; stroke rehabilitation; stroke trials; suburb; telestroke; Achievement; Adult; Area; Blood Vessels; Boston; Caring; Child; Childhood stroke; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Discipline; Emergency Medicine; Enrollment; Funding; General Hospitals; Geography; Health; Hospitals; Infrastructure; International; Investigation; Israel; Leadership; Massachusetts; Medical center; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurologic; Neurology; New England; New Hampshire; Patient Care; Pediatric Hospitals; Performance; Phase; Positioning Attribute; Principal Investigator; Records; Rehabilitation therapy; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Seasons; Site; Stroke; StrokeNet clinical trials; StrokeNet trials; Talents; Translational Research; United States National Institutes of Health; Universities; Vermont; Vision; Woman; clinical translation; innovation; member; metropolitan; neuroimaging; neurosurgery; patient population; pre-clinical; programs; recruit; skills; stroke neurology; stroke rehabilitation; stroke trials; suburb; telestroke

PROJECT SUMMARY/ABSTRACT We propose to continue the StrokeNet New England Regional Coordinating Center (NERCC), an integrated team of hospitals in the Greater Boston Area and suburbs, Western Massachusetts, New Hampshire and Vermont that will serve as a top-enrolling site and vibrant contributor to the NINDS StrokeNet Clinical Trials Network. Our group includes most of the major academic adult and pediatric stroke and rehabilitation hospitals in Massachusetts, New Hampshire and Vermont. Our 30+ hospital New England TeleStroke referral network will extend our potential recruitment and become particularly relevant with the upcoming STEP platform trials. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across multiple disciplines. The leadership team composed of Principal investigator Aneesh Singhal, MD, Deputy PI Natalia Rost MD, MPH, Site PIs, Deputy Site PIs, and Co-Investigators bring a diverse and complementary set of skills in managing successful translational clinical research programs, serving as members on trial Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators and site PIs; 2) a large patient population with geographically diverse hospital settings anchored in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure at most of the sites; 5) existing clinical research programs, e.g., MGH Neurological Clinical Research Institute, NIH Clinical and Translational Science Award programs serving Boston University and all Harvard hospitals; and 6) leadership roles in the SIREN-NETT, NeuroNEXT, DISCOVERY and MarkVCID trial networks. Overall, the NERCC Team has demonstrated outstanding commitment and performance in the first two StrokeNet cycles, and has the resources, vision, and enthusiasm to continue to develop new translational science and successfully execute the NINDS StrokeNet Phase 1,2 and 3 trials.

项目摘要/摘要 我们建议继续统一的新英格兰地区协调中心（NERCC），这是一个综合的 大波士顿地区和郊区，马萨诸塞州西部，新罕布什尔州和 佛蒙特州将成为Ninds Strokenet临床试验的顶级入围站点和生动的贡献者 网络。我们的小组包括大多数主要的学术成人和小儿中风和康复医院 在马萨诸塞州，新罕布什尔州和佛蒙特州。我们的30多个医院新英格兰电视推荐网络 将扩大我们的潜在招聘，并与即将进行的阶梯平台试验特别相关。 所有核心医院都有成功的临床试验管理和性能的可靠记录。在 特别是，所有医院都有建立的研究基础设施，该基础设施正在进行中 跨多个学科的牢固合作，中风神经病学。由 首席研究员Aneesh Singhal，医学博士，PI Natalia Rost MD，MPH，Site PIS，PIS，副地PIS和 共同投资者带来了管理成功翻译临床的多样化和互补的技能 研究计划，担任试用指导委员会的成员，以及国家领导职位 他们的领域。我们的团队包括经验丰富的血管神经病学临床研究人员，急诊医学， 神经内血管，神经外科手术，神经性护理，神经影像学，中风康复和临床前 成人和儿童的基本和翻译中风调查。 NERCC团队的优势包括 1）多个调查员与现场PI之间的个人和专业联系； 2）一个大患者 拥有地理位置多样化医院环境的人口锚定在一个主要的大都市地区； 3）才华横溢 现场调查人员的团队具有科学成就，创新和主题招聘的记录 多中心试验； 4）在现有NINDS资助的研究和临床试验管理基础设施 大多数站点； 5）现有的临床研究计划，例如MGH神经临床研究所， NIH临床和转化科学奖计划为波士顿大学和所有哈佛医院提供服务； 6）在警笛声，Neuronext，Discovery和MarkVCID试验网络中的领导角色。全面的， NERCC团队在前两个Strokenet中表现出杰出的承诺和表现 循环，并具有继续发展新的翻译科学的资源，愿景和热情 成功地执行Ninds Strokenet阶段1,2和3次试验。