Alcohol-related sleep disturbances and circuit dynamics of arousal neuropeptides

酒精相关的睡眠障碍和唤醒神经肽的回路动力学

基本信息

批准号：
10846888
负责人：
William J Giardino
金额：
$ 9.31万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10846888
关键词：
Affect Alcohol consumption Alcohol withdrawal syndrome Alcoholism Alcohols Amygdaloid structure Anatomy Animal Model Animals Anxiety Arousal Automobile Driving Axon Behavioral Blood alcohol level measurement Brain Calcium Cells Characteristics Chronic Chronic Disease Corticotropin-Releasing Hormone Development Drug abuse Electroencephalography Environment Fiber Fluorescence Functional Magnetic Resonance Imaging Future Heavy Drinking Hyperactivity Hypothalamic structure Individual Knowledge Laboratories Lateral Life Link Measurement Mediating Metabolic Methods Monitor Motivation Mus Negative Reinforcements Neurobiology Neurocognitive Neuronal Plasticity Neurons Neuropeptides Output Pathway interactions Pattern Pharmaceutical Preparations Photometry Physiological Physiology Population Predisposition Process Public Health Receptor Signaling Relapse Research Rest Rewards Rodent Scientific Advances and Accomplishments Seizures Signal Transduction Sleep Sleep Deprivation Sleep Wake Cycle Sleep disturbances Sleeplessness Societies Stress Structure Structure of terminal stria nuclei of preoptic region Subgroup System Techniques Testing Time Ventral Tegmental Area Viral Wakefulness Water Withdrawal addiction alcohol effect alcohol exposure alcohol monitoring alcohol seeking behavior alcohol use disorder allostasis allostatic load anxiety-like behavior binge drinking cell type circadian design drinking drug relapse drug reward drug withdrawal emotional behavior emotional stimulus experimental study hypocretin improved in vivo negative emotional state neural neural circuit neuroimaging neurophysiology new technology next generation non rapid eye movement optogenetics permissiveness poor sleep problem drinker response sleep quality tool

项目摘要

Project Summary Alcoholism is a chronic disorder with severe consequences to physiology of affected individuals, and far- reaching effects on society in general. In particular, further research is required to advance scientific knowledge of the intricate neurobiology underlying the relationship between excessive alcohol drinking and deficits in sleep, a fundamental component of life. This proposal will integrate in vivo measurements of neural calcium activity with electroencephalogram sleep recordings in animal models of long-term, free-choice intermittent heavy alcohol exposure, in order to establish (or refute) causal relationships between the hypothalamic hypocretin system, extended amygdala corticotropin-releasing factor system, and stress-like states of hyperarousal (disrupted sleep) during alcohol withdrawal. Knowledge gained from the proposed experiments will inform future strategies for mitigation of drug abuse and relapse.

项目摘要酒精中毒是一种慢性疾病，对受影响个体的生理学造成严重影响，并且对社会产生影响。特别是需要进一步的研究以提高科学了解过度饮酒与睡眠不足，生活的基本组成部分。该建议将在神经的体内测量中整合长期，自由选择的动物模型中的脑电图睡眠记录的钙活性间歇性大量酒精暴露，以建立（或驳斥）因果关系下丘脑降压素系统，延长的杏仁核皮质激素释放因子系统和应力样在戒酒期间，高阳光状态（睡眠中断）。从拟议中获得的知识实验将为减轻药物滥用和复发的未来策略提供信息。