Neurophysiological Social Reward Processing, Birth Trauma, and Depression Symptoms in the Peripartum Period

神经生理学社会奖赏处理、分娩创伤和围产期抑郁症状

• 批准号: 10824066
• 负责人: Emilia Francina Cardenas
• 金额: $ 4.77万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-08 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10824066
• 关键词: Accounting; Automobile Driving; Behavior; Birth; Birth trauma; Brain; Brain region; Childbirth; Code; Cognitive; Cues; Data; Depressed mood; Development; Diagnosis; Dimensions; Distress; Electroencephalography; Emergency Situation; Emotional; Environmental Risk Factor; Etiology; Event-Related Potentials; Exhibits; Exposure to; Feedback; Fellowship; Frequencies; Funding; Future; Impairment; Infant; Intervention; Interview; Labor Complications; Longitudinal Studies; Maintenance; Measures; Medial; Medical; Mental Depression; Methods; Modeling; Mothers; Outcome; Participant; Pathway interactions; Perinatal; Postpartum Depression; Postpartum Period; Prefrontal Cortex; Pregnancy; Process; Protocols documentation; Reporting; Research; Research Personnel; Rewards; Risk; Risk Factors; Role; Severities; Shapes; Social Impacts; Stimulus; Stress; Stressful Event; Testing; Time; Training; Trauma; Ventral Striatum; Woman; adverse outcome; antepartum depression; career; caregiving; contextual factors; depression model; depressive symptoms; expectation; experience; functional disability; innovation; maternal outcome; neural; neurophysiology; novel; offspring; peripartum depression; pre-doctoral; prospective; response; reward processing; skills; social; social attachment; suicidal risk; trauma symptom

PROJECT SUMMARY/ABSTRACT Peripartum depression (i.e., depression during pregnancy and following childbirth; PPD) is prevalent and debilitating for women. PPD is associated with significant negative outcomes, including functional impairment and suicidality risk in mothers as well as cognitive, developmental, emotional, and social impacts on infants. Another common factor impacting women during the peripartum period is birth trauma. Nearly half of women giving birth endorse birth trauma, including labor complications, emergency interventions that violate expectations, or needs for intensive medical treatment. Depression during pregnancy is a known risk factor for birth trauma. Further, birth trauma is associated with a range of adverse outcomes for mothers and offspring similar to the effects of PPD. Many women endorsing birth trauma do not develop PPD, raising questions about vulnerabilities for depression that may contribute to PPD in interaction with birth trauma. Vulnerability- stress models of depression posit depression is the result of interactions between underlying vulnerabilities and stress. Growing evidence supports the use of neuroscientific methods to identify depression vulnerabilities across development, such as reduced neural reward responsiveness. Further, stress moderates effect of reward processing on subsequent depression. Reward processing may interact with birth trauma on PPD symptoms. As part of a larger project, this project measures neural social reward responsiveness using a novel and ecologically valid paradigm, birth trauma objectively coded based on contextual factors, and depressive symptoms assessed in 120 mothers. Depression symptoms and diagnoses are collected across pregnancy and postpartum. During an assessment at 8 weeks postpartum, participants complete a novel social inventive delay task while electroencephalogram is recorded in response to reward (i.e., green arrow leading to a photo of participant’s infant) and neutral feedback (i.e., red arrow leading to a photo of rocks). Event-related potential (e.g., the reward positivity, a time-domain measure of reward responsiveness) and time-frequency data (i.e., delta activity, a frequency-domain marker of sensitivity to rewards) are used to measure neurophysiological response to social reward. Further, participants complete the Birth Experience Interview to capture dimensions of birth trauma (i.e., overall severity, violations of expectations, and loss of control). The project examines the effects of low social reward responsiveness (Aim 1) and birth trauma (Aim 2) on PPD symptoms, accounting for depressive symptoms during pregnancy. Further, the project tests birth trauma as a moderator of associations between social reward responsiveness and postpartum depressive symptoms, accounting for depressive symptoms during pregnancy (Aim 3). This project brings together experts in respective fields and allow for advanced training on the role of stress and trauma in PPD, advanced EEG methods, and advanced quantitative methods. The project and training provide opportunities to develop necessary skills for an independent career as a researcher identifying processes and environmental factors driving PPD risk.

项目摘要/摘要 周围抑郁症（即怀孕期间和分娩后的抑郁症； PPD）很普遍，并且 女性衰弱。 PPD与显着的负面结果有关，包括功能障碍 母亲以及对婴儿的认知，发展，情感和社会影响的自杀风险。 在期刊期间，影响女性的另一个常见因素是出生创伤。几乎一半的女人 给出出生认可出生创伤，包括劳动并发症，违反的紧急干预措施 期望或对密集治疗的需求。怀孕期间的抑郁是已知的危险因素 出生创伤。此外，出生创伤与母亲和后代的一系列不良后果有关 类似于PPD的影响。许多认可生日创伤的妇女不会发展PPD，提出问题 关于抑郁症的脆弱性，可能导致PPD与出生创伤相互作用。脆弱性 - 抑郁位置的压力模型抑郁是潜在漏洞之间相互作用的结果 和压力。越来越多的证据支持使用神经科学方法来识别抑郁症 在整个发展中，例如降低神经奖励反应能力。此外，应力调节了 在随后的抑郁症上进行奖励处理。奖励处理可能与PPD上的出生创伤相互作用 症状。作为一个较大项目的一部分，该项目使用小说来衡量神经社会奖励的响应能力 以及生态有效的范式，基于上下文因素对出生创伤和抑郁症 在120位母亲中评估的症状。在怀孕期间收集抑郁症状和诊断 和产后。在产后8周的评估中，参与者完成了一种新颖的社会创造力 在响应奖励时记录脑电图时延迟任务（即，绿色箭头导致照片 参与者的婴儿）和中性反馈（即，红色箭头导致岩石照片）。事件相关的潜力 （例如，奖励潜力，奖励响应能力的时间域度量）和时频数据（即 增量活动，一种对奖励的敏感性标记）用于测量神经生理学 对社会奖励的回应。此外，参与者完成了出生经验面试以捕捉维度 出生创伤（即总体严重程度，违反期望和失控）。项目考试 低社会奖励反应能力（目标1）和出生创伤（目标2）对PPD症状，会计的影响 怀孕期间的抑郁症状。此外，该项目测试生日创伤作为主持人 社会奖励响应能力与产后抑郁症状之间的关联，考虑到 怀孕期间的抑郁症状（AIM 3）。该项目汇集了相对领域的专家 允许对压力和创伤在PPD，高级脑电图方法中的作用和高级培训进行高级培训 定量方法。该项目和培训为开发必要技能提供了机会 作为研究人员的独立职业，确定了推动PPD风险的过程和环境因素。