COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA RESEARCH

流感疫苗合作创新中心：通用流感研究

• 批准号: 10829327
• 负责人: FLORIAN KRAMMER
• 金额: $ 1399.71万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2025-08-04
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10829327
• 关键词: Biological Assay; Clinical Research; Clinical Trials; Development; Evaluation; Immunity; Immunologics; In Vitro; Influenza; Reagent; Research; Vaccine Design; design; efficacy testing; immunogenicity; in vivo; influenza virus strain; influenza virus vaccine; innovation; universal influenza vaccine; vaccine candidate; vaccine delivery

To support the design and evaluation of innovative influenza vaccine candidates and delivery platforms that aim to achieve durable, robust and broadly protective immunity against multiple strains of influenza virus. Activities may include immunologic analyses to inform vaccine design and identify surrogates/correlates of protection; in vitro and in vivo immunogenicity and efficacy testing; assay and reagent development; and clinical studies and trials.

支持创新的流感疫苗候选疫苗和送达平台的设计和评估，旨在实现耐用，健壮和广泛的保护性免疫，以抗多种流感病毒菌株。活动可能包括免疫分析，以告知疫苗设计并确定保护的替代物/相关性；体外和体内免疫原性和功效测试；测定和试剂开发；以及临床研究和试验。