Symposium on Obesity and Transplantation: Comparing Medical Nutrition Therapy, Pharmacotherapy, and Bariatric Surgery

肥胖与移植研讨会：医学营养疗法、药物疗法和减肥手术的比较

• 批准号: 10828092
• 负责人: Heather Marie Gardiner
• 金额: $ 5万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10828092
• 关键词: Symposium; Obesity; Transplantation; Comparing; Medical

PROJECT SUMMARY Obesity continues to be a significant barrier to solid organ transplantation. Patients with obesity awaiting kidney, liver, and heart transplantation are often delayed or denied transplants until weight loss is achieved. We propose a research development conference to review and discuss the evidence-base and current practices surrounding the use of medical nutritional therapy, pharmacotherapy, and bariatric surgery to support patients' weight loss prior to solid organ transplantation. The proposed Symposium on Obesity and Solid Organ Transplantation: The Role of Medical Nutrition Therapy, Pharmacotherapy, and Bariatric Surgery, will convene a multidisciplinary group of clinicians, researchers and allied health professionals (i.e., social workers, nutritionists, dieticians) in the fields of solid organ transplantation and obesity as well as patients with obesity awaiting transplantation to develop an agenda for future comparative effectiveness research at the intersection of these fields and develop strategies for reducing delays in the receipt of life-saving and life-changing transplants and wait list mortality for patients with obesity. The proposed research development conference builds on our successful AHRQ-funded Symposium on Obesity and Kidney Transplantation held in May of 2021 (R13HS028377). This inaugural hybrid event garnered 486 registrants and 317 attendees; the meeting also generated 56 research questions and overwhelmingly positive reviews. The proposed conference expands on this inaugural event and aims to: 1) elicit patient perspectives on and experiences with regarding the challenges and successes of weight loss and management in preparation for kidney, liver and heart transplantation; 2) provide a forum for sharing research findings and clinical experience related to the use of medical nutritional therapy, pharmacotherapy, and bariatric surgery to address obesity prior to transplantation; 3) generate a research agenda, including specific research questions, to investigate issues related to obesity and transplantation. We propose to organize, advertise, implement and evaluate the symposium, and disseminate the resulting content in collaboration with our existing Steering Committee. In addition, three patients who have been evaluated and waitlisted for kidney, liver, lung, or heart transplantation and who concurrently suffer from obesity that is delaying transplantation will be recruited as patient partners to serve as members of the Steering Committee. Three additional patient partnerss will serve as symposium panelists and will share personal experience with weight loss as a transplant candidate to an audience of clinicians, researchers and allied health professionals. Our anticipated outcomes include a manuscript from the symposium content and discussions, and an agenda with specified research questions for future comparative effectiveness research on the use of medical nutritional therapy, pharmacotherapy, and bariatric surgery to treat obesity prior to solid organ transplantation.

项目摘要 肥胖仍然是固体器官移植的重大障碍。肥胖症患者正在等待 肾脏，肝脏和心脏移植通常被延迟或拒绝移植，直到体重减轻为止。 我们提出了一个研究开发会议，以审查和讨论证据库和当前 围绕使用医疗营养疗法，药物治疗和减肥手术的实践 患者在固体器官移植之前的体重减轻。拟议的肥胖和固体研讨会 器官移植：医学营养疗法，药物治疗和减肥手术的作用，将 召集一个多学科的临床医生，研究人员和盟友卫生专业人员（即社会工作者， 营养学家，营养师）在固体器官移植和肥胖领域以及肥胖症患者 等待移植以制定与十字路口的未来比较有效性研究的议程 在这些领域，并制定了减少延误的策略，以挽救生命和改变生命 移植并等待肥胖患者的死亡率。拟议的研究开发会议 建立在我们成功的AHRQ资助的肥胖和肾脏移植研讨会上 2021（R13HS028377）。这次首届混合活动吸引了486名注册人和317名与会者；会议 还产生了56个研究问题和绝大多数的正面评价。拟议的会议 扩展这一首届活动，目的是：1）引起患者对有关的观点和经验 减肥和管理的挑战和成功，为肾脏，肝脏和心脏做准备 移植； 2）提供一个论坛，用于分享与使用有关的研究结果和临床经验 在移植之前，医疗营养疗法，药物治疗和减肥手术可解决肥胖症； 3）产生研究议程，包括特定的研究问题，以调查与肥胖有关的问题 和移植。我们建议组织，宣传，实施和评估研讨会，以及 与我们现有的指导委员会合作传播结果内容。另外，三个 已评估和等待肾脏，肝脏，肺或心脏移植的患者以及谁 同时遭受延迟移植的肥胖症，将被招募为患者伴侣 指导委员会成员。另外三个患者伴侣将担任专题讨论会上的小组成员和 将与临床医生的观众分享体重减轻的个人经验， 研究人员和相关卫生专业人员。我们预期的结果包括 研讨会内容和讨论，以及带有特定研究问题的议程 对使用医学营养疗法，药物治疗和减肥手术的有效研究 在固体器官移植之前治疗肥胖。