NIAID CENTERS OF EXCELLENCE FOR INFLUENZA RESEARCH AND RESPONSE: UNIVERSAL INFLUENZA RESEARCH ACTIVITIES

NIAID 流感研究和应对卓越中心：通用流感研究活动

• 批准号: 10819116
• 负责人: SCOTT HENSLEY
• 金额: $ 642.81万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10819116
• 关键词: Advanced Development; Animals; Basic Science; Cohort Studies; Disease Outcome; Environmental Risk Factor; Evolution; Human; Immune; Immune response; Immunologic Factors; Influenza; Influenza vaccination; Molecular; National Institute of Allergy and Infectious Disease; Pathogenicity; Research; Research Activity; Sampling; Vaccination; cross immunity; improved; influenza infection; influenzavirus; response; transmission process; universal influenza vaccine

CEIRR will determine the molecular, ecologic and/or environmental factors that influence the evolution, emergence, transmission and pathogenicity of influenza viruses, and characterize the immune response to influenza infection to improve understanding of the immune correlates of protection and cross-protection. CEIRR will carry out a host of activities, including cohort studies and human and animal sampling to further understanding of influenza infection, transmission and vaccination; identification of immunological factors that determine disease outcome in the response to influenza infection and vaccination; and studies to determine how influenza viruses evolve, adapt and transmit between humans and at interspecies interfaces.

CEIRR将确定影响流感病毒进化、出现、传播和致病性的分子、生态和/或环境因素，并表征对流感感染的免疫反应，以增进对保护和交叉保护的免疫相关性的理解。 CEIRR将开展一系列活动，包括队列研究以及人类和动物采样，以进一步了解流感感染、传播和疫苗接种；确定流感感染和疫苗接种反应中决定疾病结果的免疫因素；以及确定流感病毒如何在人类之间和物种间界面进化、适应和传播的研究。