Neural circuits for decision making

用于决策的神经回路

基本信息

批准号：
10818860
负责人：
Eun Jung Hwang
金额：
$ 39万
依托单位：
ROSALIND FRANKLIN UNIV OF MEDICINE & SCI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-13 至 2025-03-31
项目状态：
未结题

项目摘要

PROJECT SUMMARY Different people facing similar situations make different choices, and different choices result in divergent life trajectories. Despite the pervasive impact on an individual’s life, the neural basis of idiosyncratic decision-making remains largely unknown. Beginning to address this important topic, we recently characterized idiosyncratic choice behavior quantitatively and identified a posterior network comprised of the cingulate cortex, posterior parietal cortex, and striatum in which the idiosyncratic choice biases are likely processed, transmitted, and integrated with other decision variables. The posterior network imbuing idiosyncrasy might operate in parallel to the well-known frontal network for rule- and value-based decision-making and the sensorimotor network for stimulus-response association, all of which dynamically contribute to the final choice. However, the detailed circuit mechanisms in the posterior network have yet to be discovered. We propose a series of experiments in mice to elaborate information flows and processing in the posterior network, utilizing well-established in-lab tools including behavior modeling, anterograde- and retrograde-transsynaptic labeling, optogenetics, and two-photon imaging. Understanding the neural circuits governing the moment-by-moment idiosyncratic history bias will shed light on the neural origins of idiosyncratic decisions. Furthermore, life-interfering, maladaptive choice behavior might be in part a manifestation of extremely deviated idiosyncratic bias, thus elaborating the less known posterior network may bring new insights into pathological decision-making in neurological conditions such as aging, dementia, and addiction.

项目摘要面临类似情况的不同人会做出不同的选择，而不同的选择导致不同的生活轨迹。尽管对个人的生活产生了普遍的影响，但神经基础特质的决策在很大程度上仍然未知。开始解决这个重要主题，我们最近定量表征了特质选择行为，并确定了后部网络完成扣带回皮质，后顶叶皮层和纹状体的网络完成特质选择偏见可能是处理，传播和集成的其他决定变量。后验网络浸入特质可能与众所周知的基于规则和价值决策的额叶网络以及用于感觉运动网络的网络刺激反应关联，所有这些都动态地有助于最终选择。然而，后网络中的详细电路机制尚未发现。我们建议在小鼠中进行了一系列实验，以详细说明信息流和后期处理网络，使用良好的单行内工具，包括行为建模，顺行 - 和逆行 - 转向标记，光遗传学和两光子成像。了解逐步管理的神经回路偏见会揭示特质决定的神经起源。此外，生活疗法，适应不良的选择行为可能部分是极度偏差的特质偏见的表现，从而阐述鲜为人知的后网络可能会给病理决策带来新的见解神经系统疾病，例如衰老，痴呆和成瘾。