SCH: A Novel Bias-mitigated Multimodal Oxygen Monitor

SCH：一种新型的消除偏差的多模式氧监测仪

基本信息

批准号：
10816771
负责人：
Ulkuhan Guler
金额：
$ 28.51万
依托单位：
WORCESTER POLYTECHNIC INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10816771
关键词：
Admission activity Adverse effects Algorithms Binding Biomedical Research Biosensing Techniques Blood Blood gas COVID-19 Clinical Collection Custom Data Data Set Diffusion Ecosystem Effectiveness Electronics Equity Event Female Gases Goals Gold Hemoglobin Home International Journals Justice Knowledge Life Literature Lung Machine Learning Measurement Measures Medical Medicine Methods Miniaturization Modality Monitor Neonatal Intensive Care Units Outcome Outpatients Oxygen Oxygen Therapy Care Partial Pressure Patients Pigmentation physiologic function Play Process PtcO2 Research Research Personnel Resolution Resources Respiratory Disease Respiratory distress Role SMART health Sensitivity and Specificity Skin Time Transcutaneous Blood Gas Monitoring Validation Work clinical practice connected health design graduate student improved improved outcome individualized medicine infant monitoring miniaturize monitoring device multimodality neonate novel pandemic disease people of color racial bias readmission risk recruit remote assessment remote monitoring remote patient monitoring respiratory sensor sensor technology signal processing skin color symposium time use treatment planning undergraduate student wearable device

项目摘要

Annually, ∼300,000 neonates are admitted to the neonatal intensive care unit (NICU) in the U.S., mostly due to respiratory distress. After a successful medical treatment in the NICU, earlier discharge to a stable home life could improve the chance of survival for neonates. However, the outpatient management of babies with fragile respiratory status is challenging in the absence of reliable remote monitoring devices suitable for use at home. Due to the small form factor and ease of use, contemporary home monitoring devices deploy sensors measuring SpO2, the saturation of hemoglobin bound to oxygen. Nevertheless, accurate assessment of oxygenation is complicated and not possible with only one parameter. Therefore, in clinical practice, invasive blood gas measurements - including partial pressure of oxygen (PaO2), which is the free dissolved oxygen (not bound to hemoglobin) - are not entirely replaced with SpO2. PaO2 is an essential cardio-respiratory measurement and the direct indication of lung effectiveness. A direct noninvasive method of assessing PaO2 is PtcO2, oxygen gas that diffuses through the skin. Creating an ability to sense two respiratory parameters (PtcO2 and SpO2) with one wearable is unique and superior to the current practice of measuring only SpO2, filling an important gap in miniaturization of the transcutaneous blood gas monitors.

每年，约30万名新生儿被美国新生儿重症监护室（NICU）接纳由于呼吸窘迫。在NICU成功治疗后，早期出院家庭生活可以提高新生儿生存的机会。但是，门诊管理在没有可靠的远程监控设备的情况下，具有脆弱呼吸状况的婴儿具有挑战性适合在家使用。由于形状较小和易用性，现代家庭监控设备部署测量SPO2的传感器，与氧气结合的血红蛋白的满意度。尽管如此，准确评估氧合是复杂的，仅用一个参数就无法进行。所以，在临床实践中，侵入性血液气体测量 - 包括氧的部分压力（PAO2），其中是自由溶解的氧（与血红蛋白不结合的氧气） - 并未完全被SPO2取代。 Pao2是一个必需的心脏呼吸测量和肺有效性的直接指示。直接评估PAO2的非侵入性方法是PTCO2，氧气通过皮肤扩散。创建一个能够感知具有一个可穿戴的两个呼吸参数（PTCO2和SPO2）的能力是独一无二的当前仅测量SPO2的实践，填补了小型化的重要空白经皮的血液气体监测器。