The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial

MyGoals 健康老龄化多中心随机对照试验

基本信息

批准号：
10800917
负责人：
Daniel Walker Belsky
金额：
$ 13万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10800917
关键词：
Acceleration Age Aging Algorithms Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Area Automobile Driving Behavioral Biological Biological Aging Biological Assay Blood Blood Glucose Blood specimen Brain C-reactive protein Caring Cause of Death Central Nervous System Cessation of life Chronic Disease Cognition Cognitive Cognitive Science Collaborations Collection Consultations Control Groups Crime DNA Methylation Data Data Collection Data Linkages Data Set Development Diabetes Mellitus Diet Disadvantaged Economics Emotional Employment Executive Dysfunction Exercise Family Funding Future Genes Glycosylated hemoglobin A Goals Health Health Food Health Insurance Health Status Health behavior Height Homeostasis Housing Human Human Resources Incentives Income Individual Intervention Investigation Laboratories Link Loneliness Longevity Maintenance Measures Medical Memory Mental Depression Mental Health Methodology Methods Moods Motivation National Institute on Aging Neurons Obesity Outcome Outcome Assessment Outcome Measure Participant Pathway interactions Personal Satisfaction Persons Phase Population Poverty Premature aging syndrome Process Psyche structure Psychological Stress Psychologist Public Housing Randomized Randomized, Controlled Trials Records Research Resources Risk Services Sleep Social Functioning Social Policies Social outcome Stress Surveys System Testing Time Unemployment United States Dept. of Health and Human Services Weight Work age related biobank blood pressure regulation body system cohort dementia risk design diet and exercise disparity elimination disparity reduction economic outcome electronic data executive function field study follow-up frailty health disparity health related quality of life healthy aging improved innovation interdisciplinary approach intervention effect loss of function methylation pattern minority investigator mortality neural novel nutrition patient engagement physical conditioning prevent programs randomized trial research and development social social health determinants success treatment group welfare whole genome

项目摘要

Poverty is associated with harsh living conditions, few opportunities to exercise, and poor access to healthy food that collectively produce “wear and tear” on organ systems. Psychological stress increases the fragility of neurons in the central nervous system, potentially producing both the loss of function and volume in areas of the brain that are involved in maintaining homeostasis (e.g., blood glucose), planning tasks, executing tasks, motivation, and emotional control. Psychological stress and poor nutrition can accelerate the aging process, and may manifest as executive function deficits, diabetes, obesity, Alzheimer's disease/Alzheimer's disease- related dementias (AD/ADRD), and early death. The mechanisms by which poverty-associated stress accelerates aging are known, but there is no proven intervention to slow the rapid pace of aging among impoverished families. Anti-poverty programs are a logical point of intervention. An ongoing randomized-controlled trial (RCT), MyGoals for Employment Success, intervenes on both poverty using proven employment incentives and on executive function deficits using a field-tested coaching program. That study was designed to evaluate outcomes associated with executive function, economic well-being, and social functioning. To evaluate outcomes associated with aging, additional intervention time and follow up are needed because health outcomes tend to lag economic outcomes. The National Institute on Aging provided one year of funding for cohort maintenance and to re-design MyGoals for Employment Success into a healthy aging study with three years of intervention time, six years of follow up, and health, aging, and cognition measures. This re-design was done in collaboration with leading interdisciplinary experts using the Delphi method, a formalized process for understanding how to optimize measure selection and the timing of measure collection. With their input, we propose an innovative RCT that we call MyGoals for Healthy Aging. We will measure the effect of the intervention on psychological stress, diet, sleep, mood, loneliness, height, weight, executive function, blood sugar, high-sensitivity C-reactive protein, and gene methylation patterns. We will also store blood for future “freezer studies” that allow for more sophisticated measures of human aging. In addition, we will maintain an ongoing dataset linked to electronic data so that it is possible to measure outcomes beyond the time frame of the study, including future income and mortality by cause of death. Completion of these aims will provide foundational evidence on the ability of social policy to influence aging-related health outcomes; our ultimate goal is to test a novel intervention that might reduce or eliminate disparities in chronic diseases including AD/ADRD.

贫困与Harmsh的生活条件相关，几乎没有锻炼的机会，并且无法获得健康在器官系统上共同产生“磨损”的食物。心理压力增加了中枢神经系统中的神经元可能会在涉及维持体内稳态的大脑（例如，血糖），计划任务，执行任务，动机和情感控制。心理压力和营养不良可以加速衰老过程，并且可能表现为执行功能缺陷，糖尿病，肥胖症，阿尔茨海默氏病/阿尔茨海默氏病 - 相关痴呆症（AD/ADRD）和早期死亡。与贫困相关的压力的机制已知加速衰老，但是没有经过证实的干预措施来减缓衰老的迅速步伐贫穷的家庭。反贫困计划是逻辑上的干预点。正在进行的随机控制试验（RCT），即就业成功的Mygoals，介入两个贫困使用经过验证的就业激励措施和执行功能使用现场测试的教练计划定义。该研究旨在评估与执行功能，经济福祉和社会功能。为了评估与衰老相关的结果，额外的干预时间和随访是由于健康结果倾向于滞后经济成果，因此需要。美国国家衰老研究所提供了一年的队列维护资金，并重新设计了Mygoals 在三年的干预时间，随访六年的情况下，就就业成就了健康的衰老研究，以及健康，衰老和认知措施。此重新设计是与领先的使用Delphi方法的跨学科专家，这是一个正式的过程，用于理解如何优化测量选择和测量收集的时间。通过他们的意见，我们提出了一个创新的RCT 我们致电Mygoals以进行健康衰老。我们将衡量干预对心理压力，饮食，睡眠，情绪，孤独，身高，体重，执行功能，血糖，高敏性C反应蛋白和基因甲基化模式。我们还将为将来的“冰柜研究”存储血液，以使得更复杂人类衰老的度量。此外，我们将维护一个正在进行的数据集，该数据集链接到电子数据，以便它可以衡量超出研究时间范围的结果，包括未来收入和死亡率死亡原因。这些目标的完成将提供有关社会政策能力的基本证据影响与衰老有关的健康结果；我们的最终目标是测试可能减少或消除包括AD/ADRD在内的慢性疾病中的分布。