Methods and Strategies for the Concise Synthesis of Complex Alkaloid Natural Products - Equipment Supplement

复杂生物碱天然产物的简明合成方法与策略 - 设备补充

• 批准号: 10798860
• 负责人: VIRESH H. RAWAL
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10798860
• 关键词: Alkaloids; Complex; Equipment; Funding; Grant; High temperature of physical object; Indole Alkaloids; Methods; National Institute of General Medical Sciences; Natural Products; Organic Synthesis; Reaction; Reaction Time; Robot; Side; Source; United States National Institutes of Health; Work; chemical synthesis; microwave electromagnetic radiation

Summary of the Request. We are requesting funds for the purchase of a microwave synthesizer, the Biotage Initiator+ with Robot Eight, to enable the precise and efficient synthesis of complex organic molecules. Microwave-based synthesis represents an established method for chemical synthesis, especially for reactions that require high temperatures, due to its ability to provide higher yields, fewer side products, and shorter reaction times. This reactor will enable us to perform complex organic syntheses under controlled conditions of intense, even heat from a safe microwave source. Additionally, the auto-sampler accessory will facilitate the optimization of reaction conditions and the exploration of a wider range of reaction substrates. Overall, the reactor will significantly enhance our ability to complete the work outlined in our grant, “New Methods and Strategies for the Concise Synthesis of Complex Indole Alkaloids” (NIH- NIGMS 5R01GM144663-02).

请求摘要 我们正在请求资金购买微波合成器，即 Biotage Initiator+ 与 Robot八，能够精确、高效地合成复杂的有机化合物 基于微波的合成代表了化学合成的既定方法，尤其是。 对于需要高温的反应，由于其能够提供更高的产率、更少的副产物， 该反应器将使我们能够进行复杂的有机合成。 来自安全微波源的受控强烈、均匀热量条件。 附件将有助于反应条件的优化和更广泛的探索 总体而言，该反应器将显着增强我们完成概述工作的能力。 在我们的资助中，“复杂吲哚生物碱简明合成的新方法和策略”（NIH- NIGMS 5R01GM144663-02）。

项目成果

Rapid Access to 2,2-Disubstituted Indolines via Dearomative Indolic-Claisen Rearrangement: Concise, Enantioselective Total Synthesis of (+)-Hinckdentine A.

• DOI: 10.1021/jacs.3c03611
• 发表时间: 2023-07-12
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Baidilov, Daler;Elkin, Pavel K.;Athe, Sudhakar;Rawal, Viresh H.
• 通讯作者: Rawal, Viresh H.

Dearomative (4 + 3) Cycloaddition Reactions of 3-Alkenylindoles and 3-Alkenylpyrroles to Afford Cyclohepta[b]indoles and Cyclohepta[b]pyrroles.

• DOI: 10.1021/acs.orglett.2c02983
• 发表时间: 2022-11-11
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Taenzler, Ferdinand;Xu, Jiasu;Athe, Sudhakar;Rawal, Viresh H.
• 通讯作者: Rawal, Viresh H.